IN2012DN00711A - - Google Patents
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- Publication number
- IN2012DN00711A IN2012DN00711A IN711DEN2012A IN2012DN00711A IN 2012DN00711 A IN2012DN00711 A IN 2012DN00711A IN 711DEN2012 A IN711DEN2012 A IN 711DEN2012A IN 2012DN00711 A IN2012DN00711 A IN 2012DN00711A
- Authority
- IN
- India
- Prior art keywords
- pharmaceutically active
- layers
- disclosed
- active ingredient
- layer
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 abstract 3
- 229920002379 silicone rubber Polymers 0.000 abstract 2
- 239000006213 vaginal ring Substances 0.000 abstract 2
- 238000009792 diffusion process Methods 0.000 abstract 1
- 238000001125 extrusion Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27139109P | 2009-07-21 | 2009-07-21 | |
| PCT/US2010/030183 WO2011011099A1 (en) | 2009-07-21 | 2010-04-07 | Multi-layered gradient vaginal ring |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00711A true IN2012DN00711A (en) | 2015-06-19 |
Family
ID=42236498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN711DEN2012 IN2012DN00711A (en) | 2009-07-21 | 2010-04-07 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8753667B2 (en) |
| EP (1) | EP2456421B1 (en) |
| JP (1) | JP5690826B2 (en) |
| CN (1) | CN102497855B (en) |
| AU (1) | AU2010274946B2 (en) |
| BR (1) | BR112012001353B8 (en) |
| CA (1) | CA2767967C (en) |
| CO (1) | CO6491080A2 (en) |
| DK (1) | DK2456421T3 (en) |
| ES (1) | ES2626156T3 (en) |
| IN (1) | IN2012DN00711A (en) |
| MX (1) | MX2012000948A (en) |
| WO (1) | WO2011011099A1 (en) |
| ZA (1) | ZA201200809B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| DE202011110355U1 (en) * | 2011-03-09 | 2014-01-15 | Arstat, Inc. | Treatment of uterine fibroids by intravaginal administration of a low dose of a selective progesterone receptor modulator, an antigestagens or an antigestagen agent |
| FR3005417B1 (en) * | 2013-05-10 | 2015-05-22 | Blaise Francois Figuereo | VAGINAL RING TRI-TANK, RETRO-LARGAGE COMPATIBLE WITH THE CHARACTERISTICS OF ACTIVE MOLECULES IT CONTAINS |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US10413504B2 (en) * | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
| PL2982352T3 (en) | 2014-06-28 | 2019-01-31 | Laboratorios Andrómaco S.A. | Cervical pessary containing progesterone for prolonged, sustained and continuous release, used to prevent premature birth |
| US9943146B2 (en) | 2015-05-27 | 2018-04-17 | Qalo Llc | Compression molded silicone ring |
| EP3316724B1 (en) * | 2015-07-14 | 2019-09-11 | Qalo LLC | Compression molding a silicone ring |
| MX381469B (en) * | 2015-12-21 | 2025-03-12 | Bayer Oy | METHOD FOR MANUFACTURING A DEVICE FOR THE ADMINISTRATION OF DRUGS. |
| EP3272333A1 (en) | 2016-07-22 | 2018-01-24 | Chemo Research, S.L. | Vaginal composition comprising a combination of estrogen and vitamin d |
| CN106913412B (en) * | 2017-03-01 | 2023-09-22 | 上海市嘉定区妇幼保健院 | Easy-to-put and easy-to-take pessary |
| KR20210013089A (en) | 2018-05-24 | 2021-02-03 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | Implantable device for sustained release of macromolecular drug compounds |
| EP3803866A4 (en) | 2018-05-24 | 2022-03-16 | Nureva Inc. | METHOD, DEVICE AND COMPUTER-READABLE MEDIA FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE RECORDING/FOCUS ZONES |
| KR20210013088A (en) | 2018-05-24 | 2021-02-03 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | Implantable device for sustained release of macromolecular drug compounds |
| US10918649B2 (en) | 2019-06-21 | 2021-02-16 | The Population Council, Inc. | System for providing birth control |
| CN118512668A (en) * | 2019-11-12 | 2024-08-20 | 聚合-医药有限公司 | Contraceptive medical device |
| DE102021100916A1 (en) | 2021-01-18 | 2022-07-21 | Carl Freudenberg Kg | Method for producing a component, tool for carrying out the method and component which is produced by the method |
| BR112023022439A2 (en) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | IMPLANTABLE DEVICE FOR SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE494972A (en) | 1949-04-07 | |||
| US2863846A (en) | 1950-05-04 | 1958-12-09 | Dow Corning | Organo silyl-silica filled siloxane elastomers and process for producing same |
| US2890188A (en) | 1951-12-17 | 1959-06-09 | Dow Corning | Siloxane elastomers compounded with hydroxylated silanes |
| NL91756C (en) | 1953-11-19 | |||
| GB804199A (en) | 1955-12-22 | 1958-11-12 | Midland Silicones Ltd | Organosiloxane compositions |
| GB798669A (en) | 1956-12-12 | 1958-07-23 | Midland Silicones Ltd | Improvements in or relating to organosiloxane elastomer foams |
| US2927907A (en) | 1957-01-07 | 1960-03-08 | Dow Corning | Siloxane elastomers |
| US3022951A (en) | 1957-05-14 | 1962-02-27 | Ibm | Full adder |
| US3035016A (en) | 1959-03-16 | 1962-05-15 | Dow Corning | Acyloxy siloxanes and a method of using the |
| US3545439A (en) | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
| US4155991A (en) | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| US3995634A (en) | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal cavity dispensing means and method |
| US3995633A (en) | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
| US4237885A (en) | 1978-10-23 | 1980-12-09 | Alza Corporation | Delivery system with mated members for storing and releasing a plurality of beneficial agents |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| DE3040978A1 (en) | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | VAGINAL RING |
| US4596576A (en) | 1984-10-12 | 1986-06-24 | Akzo N.V. | Release system for two or more active substances |
| FR2598652B1 (en) | 1986-05-16 | 1988-08-05 | Figuereo Blaise | MULTI-MATERIAL SIMULTANEOUS EXTRUSION MACHINE |
| US4922928A (en) | 1988-08-17 | 1990-05-08 | Michael Burnhill | Vaginal device |
| WO1997002015A1 (en) | 1995-07-04 | 1997-01-23 | Akzo Nobel N.V. | Ring-shaped devices |
| US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
| IL123813A0 (en) | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| CN1536986B (en) | 2001-03-27 | 2012-07-04 | 沃纳奇尔科特(爱尔兰)有限公司 | Intravaginal drug delivery devices for administration of antimicrobial agent |
| CA2523859C (en) | 2003-04-29 | 2011-08-02 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| TWI336627B (en) * | 2003-05-23 | 2011-02-01 | Organon Nv | Drug delivery system,and use and manufacturing method thereof |
| CN1899643B (en) * | 2005-07-20 | 2010-12-29 | 上海市计划生育科学研究所 | Pessary or intrauterine medicine release device containing antiestrogenic and anti-pregnant hormone composite preparation and its use |
| US7824383B2 (en) | 2006-06-16 | 2010-11-02 | Family Health International | Vaginal drug delivery system and method |
-
2010
- 2010-04-07 IN IN711DEN2012 patent/IN2012DN00711A/en unknown
- 2010-04-07 MX MX2012000948A patent/MX2012000948A/en active IP Right Grant
- 2010-04-07 BR BR112012001353A patent/BR112012001353B8/en active IP Right Grant
- 2010-04-07 JP JP2012521631A patent/JP5690826B2/en active Active
- 2010-04-07 AU AU2010274946A patent/AU2010274946B2/en active Active
- 2010-04-07 DK DK10714730.8T patent/DK2456421T3/en active
- 2010-04-07 CA CA2767967A patent/CA2767967C/en active Active
- 2010-04-07 CN CN2010800409704A patent/CN102497855B/en active Active
- 2010-04-07 ES ES10714730.8T patent/ES2626156T3/en active Active
- 2010-04-07 WO PCT/US2010/030183 patent/WO2011011099A1/en not_active Ceased
- 2010-04-07 EP EP10714730.8A patent/EP2456421B1/en active Active
- 2010-04-07 US US13/386,172 patent/US8753667B2/en active Active
-
2012
- 2012-01-25 CO CO12011321A patent/CO6491080A2/en active IP Right Grant
- 2012-02-02 ZA ZA2012/00809A patent/ZA201200809B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5690826B2 (en) | 2015-03-25 |
| DK2456421T3 (en) | 2017-06-06 |
| BR112012001353B1 (en) | 2020-04-14 |
| CA2767967C (en) | 2014-10-21 |
| ES2626156T3 (en) | 2017-07-24 |
| HK1169614A1 (en) | 2013-02-01 |
| AU2010274946A1 (en) | 2012-03-01 |
| JP2012533401A (en) | 2012-12-27 |
| BR112012001353B8 (en) | 2021-05-25 |
| EP2456421A1 (en) | 2012-05-30 |
| CN102497855B (en) | 2013-12-25 |
| AU2010274946B2 (en) | 2013-09-12 |
| CO6491080A2 (en) | 2012-07-31 |
| MX2012000948A (en) | 2012-02-28 |
| CN102497855A (en) | 2012-06-13 |
| BR112012001353A2 (en) | 2016-04-05 |
| US8753667B2 (en) | 2014-06-17 |
| WO2011011099A1 (en) | 2011-01-27 |
| ZA201200809B (en) | 2012-10-31 |
| CA2767967A1 (en) | 2011-01-27 |
| US20120148655A1 (en) | 2012-06-14 |
| EP2456421B1 (en) | 2017-04-05 |
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