IN2012DN01268A - - Google Patents

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Publication number
IN2012DN01268A
IN2012DN01268A IN1268DEN2012A IN2012DN01268A IN 2012DN01268 A IN2012DN01268 A IN 2012DN01268A IN 1268DEN2012 A IN1268DEN2012 A IN 1268DEN2012A IN 2012DN01268 A IN2012DN01268 A IN 2012DN01268A
Authority
IN
India
Prior art keywords
temperature
polymer
islet cells
hydration
causes
Prior art date
Application number
Inventor
Hirofumi Shimizu
Kazuo Ohashi
Rie Utoh
Kazuya Ise
Masayuki Yamato
Teruo Okano
Mitsukazu Gotoh
Original Assignee
Univ Tokyo Womens Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tokyo Womens Medical filed Critical Univ Tokyo Womens Medical
Publication of IN2012DN01268A publication Critical patent/IN2012DN01268A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00—Supports and/or coatings for cell culture characterised by properties
    • C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Botany (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Endocrinology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A polymer that changes hydration at a temperature between 0 to 80°C is coated on the surface of a cell culture support, and islet cells are cultured on the support at a temperature range that causes polymer to have weak hydration, then the temperature of a culture solution is changed to a temperature that causes the polymer to have strong hydration to obtain islet cells in a sheet form. Such islet cells in a sheet form have an insulin producing function even if there is no blood flow.
IN1268DEN2012 2009-08-02 2010-08-02 IN2012DN01268A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009193648 2009-08-02
PCT/JP2010/063033 WO2011016423A1 (en) 2009-08-02 2010-08-02 Islet cell sheet, process for production thereof, and use thereof

Publications (1)

Publication Number Publication Date
IN2012DN01268A true IN2012DN01268A (en) 2015-05-15

Family

ID=43544318

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1268DEN2012 IN2012DN01268A (en) 2009-08-02 2010-08-02

Country Status (7)

Country Link
US (1) US20120210451A1 (en)
EP (1) EP2491957A4 (en)
JP (1) JP5717253B2 (en)
CN (1) CN102858380B (en)
CA (1) CA2769852A1 (en)
IN (1) IN2012DN01268A (en)
WO (1) WO2011016423A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2267115B8 (en) * 2003-02-06 2014-07-23 Cellseed Inc. Anterior ocular segment related cell sheets, three-dimensional structures, and processes for producing the same
WO2004073761A1 (en) * 2003-02-20 2004-09-02 Cellseed Inc. Endothelial cell sheet for cornea regeneration, method of producing the same and method of using the same
EP1748064B1 (en) * 2004-04-25 2019-04-17 CellSeed Inc. Cultured periodontal ligament cell sheet, process for producing the same and method of use thereof
WO2006093153A1 (en) 2005-02-28 2006-09-08 Cellseed Inc. Cultured cell sheet, process for producing the same and method for restoring tissue using the same
EP1857126B1 (en) * 2005-02-28 2018-10-24 CellSeed Inc. Cultured cell sheet, production method thereof, and application method thereof
WO2010044417A1 (en) * 2008-10-14 2010-04-22 株式会社セルシード Temperature-responsive cell culture substrate and method for producing same
JPWO2012118099A1 (en) * 2011-02-28 2014-07-07 学校法人東京女子医科大学 Cytokine producing cell sheet and method of using the same
JP2012205516A (en) 2011-03-29 2012-10-25 Osaka Univ Method for producing artificial skin model, and artificial skin model
SG194151A1 (en) * 2011-04-08 2013-11-29 Otsuka Pharma Co Ltd Method for producing sheet-like pancreatic islet
JP6189291B2 (en) 2012-05-25 2017-08-30 学校法人東京女子医科大学 Substance wettability evaluation method
JP6519050B2 (en) * 2012-09-04 2019-05-29 国立大学法人大阪大学 Artificial skin tissue, artificial skin model and method for producing them
KR102181336B1 (en) * 2013-06-13 2020-11-24 오르제네시스 엘티디. Cell populations, methods of transdifferentiation and methods of use thereof
WO2015159889A1 (en) * 2014-04-14 2015-10-22 学校法人福岡大学 Method for transplanting insulin-producing cells
MA41296A (en) 2014-12-30 2017-11-07 Orgenesis Ltd TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME
US11802265B2 (en) * 2015-06-25 2023-10-31 Auckland Uniservices Ltd Tissue culture apparatus and method
CN107709539A (en) * 2015-06-26 2018-02-16 国立研究开发法人国立循环器病研究中心 Cell culture apparatus
KR101828696B1 (en) * 2015-08-26 2018-02-12 울산대학교 산학협력단 Composition for insulin secreting cell transplantation and method for preparing the same
JP6593589B2 (en) * 2015-09-30 2019-10-23 澁谷工業株式会社 Cell mass sheet preparation method and cell mass sheet
US20170304528A1 (en) * 2016-04-22 2017-10-26 DeepScience Ltd. Implantable medical device for delivering cells
WO2018207179A1 (en) 2017-05-08 2018-11-15 Orgenesis Ltd. Transdifferentiated cell populations and methods of use thereof
TWI875793B (en) * 2019-08-08 2025-03-11 學校法人 東京女子醫科大學 Wound covering sheet and wound covering method

Family Cites Families (18)

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JPH06104061B2 (en) 1989-02-10 1994-12-21 花王株式会社 Cell culture support material
EP0470681A3 (en) * 1990-08-08 1992-04-22 W.R. Grace & Co.-Conn. Cell clusters or sheets comprising a plurality of cell species and preparations thereof
JPH05168470A (en) * 1990-08-08 1993-07-02 W R Grace & Co Cell agglomerated body and sheet consisting of multiple kinds of cells and manufacture thereof
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AU1855397A (en) * 1996-01-31 1997-08-22 Vivorx Pharmaceuticals, Inc. Process for aggregating cells and forming sheets of mammalian tissue in a horizontally rotating bioreactor
IL141858A0 (en) * 1998-09-08 2002-03-10 Privates Inst Bioserv Gmbh Diagnostic method for detecting disturbances of the pancreas
JP4567936B2 (en) * 2000-03-16 2010-10-27 株式会社セルシード Support material for cell culture, cell co-culture method and co-culture cell sheet obtained therefrom
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CN1643133A (en) * 2002-03-25 2005-07-20 华盛顿大学 Chimeric pancreas
WO2004073761A1 (en) * 2003-02-20 2004-09-02 Cellseed Inc. Endothelial cell sheet for cornea regeneration, method of producing the same and method of using the same
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Also Published As

Publication number Publication date
WO2011016423A1 (en) 2011-02-10
JPWO2011016423A1 (en) 2013-01-10
EP2491957A4 (en) 2013-10-02
US20120210451A1 (en) 2012-08-16
EP2491957A1 (en) 2012-08-29
CA2769852A1 (en) 2011-02-10
JP5717253B2 (en) 2015-05-13
CN102858380B (en) 2016-03-23
CN102858380A (en) 2013-01-02

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