IN2012DN01268A - - Google Patents

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Publication number
IN2012DN01268A
IN2012DN01268A IN1268DEN2012A IN2012DN01268A IN 2012DN01268 A IN2012DN01268 A IN 2012DN01268A IN 1268DEN2012 A IN1268DEN2012 A IN 1268DEN2012A IN 2012DN01268 A IN2012DN01268 A IN 2012DN01268A
Authority
IN
India
Prior art keywords
temperature
polymer
islet cells
hydration
causes
Prior art date
Application number
Inventor
Hirofumi Shimizu
Kazuo Ohashi
Rie Utoh
Kazuya Ise
Masayuki Yamato
Teruo Okano
Mitsukazu Gotoh
Original Assignee
Univ Tokyo Womens Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tokyo Womens Medical filed Critical Univ Tokyo Womens Medical
Publication of IN2012DN01268A publication Critical patent/IN2012DN01268A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00—Supports and/or coatings for cell culture characterised by properties
    • C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A polymer that changes hydration at a temperature between 0 to 80°C is coated on the surface of a cell culture support, and islet cells are cultured on the support at a temperature range that causes polymer to have weak hydration, then the temperature of a culture solution is changed to a temperature that causes the polymer to have strong hydration to obtain islet cells in a sheet form. Such islet cells in a sheet form have an insulin producing function even if there is no blood flow.
IN1268DEN2012 2009-08-02 2010-08-02 IN2012DN01268A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009193648 2009-08-02
PCT/JP2010/063033 WO2011016423A1 (en) 2009-08-02 2010-08-02 Islet cell sheet, process for production thereof, and use thereof

Publications (1)

Publication Number Publication Date
IN2012DN01268A true IN2012DN01268A (en) 2015-05-15

Family

ID=43544318

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1268DEN2012 IN2012DN01268A (en) 2009-08-02 2010-08-02

Country Status (7)

Country Link
US (1) US20120210451A1 (en)
EP (1) EP2491957A4 (en)
JP (1) JP5717253B2 (en)
CN (1) CN102858380B (en)
CA (1) CA2769852A1 (en)
IN (1) IN2012DN01268A (en)
WO (1) WO2011016423A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2475290T3 (en) * 2003-02-06 2014-07-10 Cellseed Inc. Cell sheets related to the anterior ocular segment, three-dimensional structures, and processes to produce them
CN1753696B (en) * 2003-02-20 2010-04-28 创革医疗科技有限公司 Regenerated corneal endothelial cell sheet, method of manufacture and method of use thereof
JP4827729B2 (en) * 2004-04-25 2011-11-30 株式会社セルシード Cultured periodontal ligament cell sheet, production method and use thereof
JPWO2006093153A1 (en) 2005-02-28 2008-08-07 株式会社セルシード Cultured cell sheet, production method, and tissue repair method using the same
ES2693609T3 (en) * 2005-02-28 2018-12-12 Cellseed Inc. Sheet of cultured cells, method for their production and method for their application
EP2348099B1 (en) * 2008-10-14 2017-07-05 CellSeed Inc. Temperature-responsive cell culture substrate and method for producing the same
CN103476439A (en) * 2011-02-28 2013-12-25 学校法人东京女子医科大学 Cytokine-producing cell sheet and method for using same
JP2012205516A (en) 2011-03-29 2012-10-25 Osaka Univ Method for producing artificial skin model, and artificial skin model
CA2833866C (en) * 2011-04-08 2019-05-21 Otsuka Pharmaceutical Factory, Inc. Method for producing sheet-like pancreatic islet
US10094816B2 (en) 2012-05-25 2018-10-09 Tokyo Women's Medical University Method of evaluating wetting characteristic of object
US20150250925A1 (en) * 2012-09-04 2015-09-10 Biomedical Technology Hybrid Co., Ltd. Artificial skin tissue, artificial skin model and manufacturing method therefor
MX2015017235A (en) * 2013-06-13 2017-05-04 Orgenesis Ltd Cell populations, methods of transdifferention and methods of use thereof.
JP6300287B2 (en) * 2014-04-14 2018-04-04 学校法人福岡大学 Insulin-producing islet cell transplant preparation
MA41296A (en) 2014-12-30 2017-11-07 Orgenesis Ltd TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME
US11802265B2 (en) * 2015-06-25 2023-10-31 Auckland Uniservices Ltd Tissue culture apparatus and method
JP6796332B2 (en) * 2015-06-26 2020-12-09 国立研究開発法人国立循環器病研究センター Method for manufacturing cell incubator and cell structure
KR101828696B1 (en) * 2015-08-26 2018-02-12 울산대학교 산학협력단 Composition for insulin secreting cell transplantation and method for preparing the same
JP6593589B2 (en) * 2015-09-30 2019-10-23 澁谷工業株式会社 Cell mass sheet preparation method and cell mass sheet
US20170304528A1 (en) * 2016-04-22 2017-10-26 DeepScience Ltd. Implantable medical device for delivering cells
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. TRANSDIFFERENTIAL CELL POPULATIONS AND METHOD OF USING THEM
TWI875793B (en) * 2019-08-08 2025-03-11 學校法人 東京女子醫科大學 Wound covering sheet and wound covering method

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
JPH06104061B2 (en) 1989-02-10 1994-12-21 花王株式会社 Cell culture support material
EP0470681A3 (en) * 1990-08-08 1992-04-22 W.R. Grace & Co.-Conn. Cell clusters or sheets comprising a plurality of cell species and preparations thereof
JPH05168470A (en) * 1990-08-08 1993-07-02 W R Grace & Co Cell agglomerated body and sheet consisting of multiple kinds of cells and manufacture thereof
JPH05192138A (en) 1992-01-22 1993-08-03 Kao Corp Method for culturing dermal cell and cultured skin
AU1855397A (en) * 1996-01-31 1997-08-22 Vivorx Pharmaceuticals, Inc. Process for aggregating cells and forming sheets of mammalian tissue in a horizontally rotating bioreactor
JP4530539B2 (en) * 1998-09-08 2010-08-25 プリファテス インスティトゥット バイオサルフ ゲーエムベーハー Diagnostic method for recognition of pancreatic dysfunction
EP1264877B1 (en) * 2000-03-16 2013-10-02 Cellseed Inc. Cell cultivation-support material, method of cocultivation of cells and cocultivated cell sheet obtained therefrom
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
BR0308718A (en) * 2002-03-25 2005-01-04 Univ Washington Chimeric Pancreas
CN1753696B (en) * 2003-02-20 2010-04-28 创革医疗科技有限公司 Regenerated corneal endothelial cell sheet, method of manufacture and method of use thereof
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
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WO2008124169A2 (en) * 2007-04-10 2008-10-16 The Trustees Of The University Of Pennsylvania Islet cells composition and methods
JP2008278769A (en) 2007-05-08 2008-11-20 Hokkaido Univ Method for producing in vitro a three-dimensional aggregate comprising islet cells

Also Published As

Publication number Publication date
EP2491957A1 (en) 2012-08-29
CA2769852A1 (en) 2011-02-10
US20120210451A1 (en) 2012-08-16
JP5717253B2 (en) 2015-05-13
JPWO2011016423A1 (en) 2013-01-10
EP2491957A4 (en) 2013-10-02
WO2011016423A1 (en) 2011-02-10
CN102858380B (en) 2016-03-23
CN102858380A (en) 2013-01-02

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