IN2012DN01342A - - Google Patents
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- Publication number
- IN2012DN01342A IN2012DN01342A IN1342DEN2012A IN2012DN01342A IN 2012DN01342 A IN2012DN01342 A IN 2012DN01342A IN 1342DEN2012 A IN1342DEN2012 A IN 1342DEN2012A IN 2012DN01342 A IN2012DN01342 A IN 2012DN01342A
- Authority
- IN
- India
- Prior art keywords
- pyrimidines
- meanings
- iii
- formula
- making
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167934 | 2009-08-14 | ||
| PCT/EP2010/061840 WO2011018518A1 (fr) | 2009-08-14 | 2010-08-13 | Préparation régiosélective de dérivés de 2-amino-5trifluorométhylpyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN01342A true IN2012DN01342A (fr) | 2015-06-05 |
Family
ID=42712695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1342DEN2012 IN2012DN01342A (fr) | 2009-08-14 | 2010-08-13 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8933227B2 (fr) |
| EP (1) | EP2464634B1 (fr) |
| JP (1) | JP5539519B2 (fr) |
| KR (1) | KR20120046248A (fr) |
| CN (1) | CN102471287A (fr) |
| AR (1) | AR077925A1 (fr) |
| AU (1) | AU2010283713A1 (fr) |
| BR (1) | BR112012002971A2 (fr) |
| CA (1) | CA2767965A1 (fr) |
| CL (1) | CL2012000278A1 (fr) |
| EA (1) | EA201200282A1 (fr) |
| IL (1) | IL217112A0 (fr) |
| IN (1) | IN2012DN01342A (fr) |
| MX (1) | MX2012001469A (fr) |
| NZ (1) | NZ597538A (fr) |
| TW (1) | TW201124385A (fr) |
| WO (1) | WO2011018518A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8372974B2 (en) * | 2008-03-20 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
| UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| WO2011018517A1 (fr) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
| CN102887860B (zh) * | 2012-09-29 | 2015-07-01 | 上海泰坦科技有限公司 | 4-氯-6-三氟甲基嘧啶类化合物的制备方法 |
| JP6391985B2 (ja) * | 2014-05-16 | 2018-09-19 | 東ソー・ファインケム株式会社 | ２−置換−４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6391988B2 (ja) * | 2014-05-21 | 2018-09-19 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体の製造方法及び新規５−（トリフルオロメチル）ピリミジン誘導体 |
| JP6262079B2 (ja) * | 2014-06-02 | 2018-01-17 | 東ソー・ファインケム株式会社 | ４−（２，２，２−トリフルオロエトキシ）−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
| JP6431294B2 (ja) * | 2014-06-16 | 2018-11-28 | 東ソー・ファインケム株式会社 | ５−（トリフルオロメチル）ピリミジン誘導体及びその製造法 |
| JP6479486B2 (ja) * | 2015-01-16 | 2019-03-06 | 東ソー・ファインケム株式会社 | ４−アルコキシ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法 |
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| JPS6262A (ja) | 1986-03-05 | 1987-01-06 | Ishihara Sangyo Kaisha Ltd | ベンゾイルウレア系化合物の製造方法 |
| GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
| WO2003030909A1 (fr) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
| ATE407678T1 (de) | 2001-10-17 | 2008-09-15 | Boehringer Ingelheim Pharma | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
| DE10161763A1 (de) | 2001-12-15 | 2003-07-17 | Bayer Cropsience Ltd | Neues herbizides Verfahren |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| WO2003095448A1 (fr) | 2002-05-06 | 2003-11-20 | Bayer Pharmaceuticals Corporation | Derives de pyridinyl amino pyrimidine utilises dans le traitement des troubles de l'hyperproliferation |
| PE20040522A1 (es) | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| JP2006508997A (ja) | 2002-11-28 | 2006-03-16 | シエーリング アクチエンゲゼルシャフト | Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用 |
| UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| CA2529611C (fr) | 2002-12-20 | 2009-12-15 | Pfizer Products Inc. | Derives de pyrimidine destines au traitement de la croissance cellulaire anormale |
| WO2005023780A1 (fr) * | 2003-09-05 | 2005-03-17 | Pfizer Products Inc. | Synthèse sélective de pyrimidines substituées en cf3 |
| US20070105839A1 (en) | 2003-09-18 | 2007-05-10 | Patricia Imbach | 2, 4-Di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| BRPI0511138A (pt) | 2004-05-14 | 2007-11-27 | Pfizer Prod Inc | derivados de pirimidina para o tratamento de desenvolvimento celular anormal |
| EP1598343A1 (fr) | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | Dérivés de 2-arylaminopyrimidines comme des inhibiteurs de PLK |
| JP2008505910A (ja) | 2004-07-08 | 2008-02-28 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Ｐｋｃ−シータのインヒビターとして有用なピリミジン誘導体 |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| ATE519759T1 (de) | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2006091737A1 (fr) | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulateurs de l'activite de gsk-3 |
| EP1705177A1 (fr) | 2005-03-23 | 2006-09-27 | Schering Aktiengesellschaft | Pyrimidines substituées par une N-aryl-sulfoximine comme inhibiteurs de CDK et de VEGF, leur préparation et utilisation comme médicaments |
| CN101218229A (zh) | 2005-05-05 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 吡唑基-氨基取代的嘧啶及其在癌症治疗中的应用 |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20070032514A1 (en) | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
| JP2009513615A (ja) | 2005-10-28 | 2009-04-02 | アストラゼネカ アクチボラグ | 癌の治療においてチロシンキナーゼ阻害剤として使用するための４−（３−アミノピラゾール）ピリミジン誘導体 |
| WO2007063384A2 (fr) | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Dérivés de pyrimidine pour le traitement de la croissance cellulaire anormale |
| CA2634646C (fr) | 2005-12-21 | 2012-04-10 | Pfizer Products Inc. | Derives pyrimidiques destines a traiter une croissance cellulaire anormale |
| TW200804364A (en) | 2006-02-22 | 2008-01-16 | Boehringer Ingelheim Int | New compounds |
| CA2648170A1 (fr) | 2006-04-10 | 2007-10-18 | Boehringer Ingelheim International Gmbh | Derives 2,4-diaminopyrimidine et leur utilisation pour traiter un cancer |
| PE20120006A1 (es) | 2006-05-15 | 2012-02-02 | Boehringer Ingelheim Int | Compuestos derivados de pirimidina como inhibidores de la quinasa aurora |
| JP5301431B2 (ja) | 2006-05-18 | 2013-09-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | キラルな環状β−アミノカルボキサミドの製造方法 |
| DE102006027156A1 (de) | 2006-06-08 | 2007-12-13 | Bayer Schering Pharma Ag | Sulfimide als Proteinkinaseinhibitoren |
| CA2654670A1 (fr) | 2006-07-06 | 2008-01-10 | Boehringer Ingelheim International Gmbh | Nouveaux composes |
| DE102006041382A1 (de) | 2006-08-29 | 2008-03-20 | Bayer Schering Pharma Ag | Carbamoyl-Sulfoximide als Proteinkinaseinhibitoren |
| WO2008040951A1 (fr) | 2006-10-03 | 2008-04-10 | Astrazeneca Ab | Composés |
| WO2008045978A1 (fr) | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Dérivés de pyrimidinediamine substitués par du pinane, utiles en tant qu'inhibiteurs de axl |
| WO2008046216A1 (fr) | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Inhibiteurs de kinase et leurs utilisations |
| RU2009112496A (ru) | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-4-имидазолы |
| ES2555803T3 (es) | 2006-10-23 | 2016-01-08 | Cephalon, Inc. | Fusión de derivados bicíclicos 2,4-diaminopirimidina como utilizar inhibidores ALK y c-Met |
| MX2009005881A (es) | 2006-12-13 | 2009-06-12 | Hoffmann La Roche | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. |
| CN101563327A (zh) | 2006-12-19 | 2009-10-21 | 健泰科生物技术公司 | 嘧啶类激酶抑制剂 |
| EP1939185A1 (fr) | 2006-12-20 | 2008-07-02 | Bayer Schering Pharma Aktiengesellschaft | Nouveaux hetaryl-phénylènediamine-pyrimidines en tant qu'inhibiteurs de protéine kinase pour le traitement du cancer |
| CN101678022A (zh) | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
| WO2008077885A2 (fr) | 2006-12-22 | 2008-07-03 | Boehringer Ingelheim International Gmbh | Nouveaux composés |
| PE20081636A1 (es) | 2007-01-26 | 2009-01-10 | Smithkline Beecham Corp | Inhibidores de antranilamida para aurora quinasa |
| WO2008118822A1 (fr) | 2007-03-23 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions et procédés d'inhibition de la voie de jak |
| CN101678215B (zh) | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
| CN101903357A (zh) | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| WO2009017838A2 (fr) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinaisons d'inhibiteurs jak-2 et d'autres agents |
| EA017252B1 (ru) | 2007-08-28 | 2012-11-30 | Айрм Ллк | Производные 2-бифениламино-4-аминопиримидина в качестве ингибиторов киназ |
| WO2009063240A1 (fr) | 2007-11-16 | 2009-05-22 | Arrow Therapeutics Limited | Dérivés de 2,4-diaminopyrimidine utiles en tant qu'inhibiteurs de l'aurora kinase |
| US8461147B2 (en) | 2007-12-03 | 2013-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
| ES2389752T3 (es) | 2007-12-14 | 2012-10-31 | Ardea Biosciences, Inc. | Inhibidores de la transcriptasa inversa |
| UY31714A (es) | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
| US8372974B2 (en) | 2008-03-20 | 2013-02-12 | Boehringer Ingelheim International Gmbh | Regioselective preparation of substituted pyrimidines |
| AU2009262198B2 (en) | 2008-06-25 | 2012-09-27 | Irm Llc | Pyrimidine derivatives as kinase inhibitors |
| PE20100087A1 (es) | 2008-06-25 | 2010-02-08 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa |
| NZ603525A (en) | 2008-06-27 | 2015-02-27 | Celgene Avilomics Res Inc | Pyrimidine based compound and uses thereof |
| EP2179991A1 (fr) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Dérivés d'anilino-pyrimidine substitués par sulfoximine en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments |
| EP2179992A1 (fr) | 2008-10-21 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Dérivés d'anilino-pyrimidine substitués par sulfone en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments |
| UY32240A (es) | 2008-11-14 | 2010-06-30 | Boeringer Ingelheim Kg | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| AR074210A1 (es) | 2008-11-24 | 2010-12-29 | Boehringer Ingelheim Int | Derivados de pirimidina como inhibidores de ptk2-quinasa |
| WO2011018517A1 (fr) | 2009-08-14 | 2011-02-17 | Boehringer Ingelheim International Gmbh | Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine |
| US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
-
2010
- 2010-08-10 US US12/853,732 patent/US8933227B2/en active Active
- 2010-08-13 TW TW099127176A patent/TW201124385A/zh unknown
- 2010-08-13 AR ARP100103001A patent/AR077925A1/es unknown
- 2010-08-13 IN IN1342DEN2012 patent/IN2012DN01342A/en unknown
- 2010-08-13 CA CA2767965A patent/CA2767965A1/fr not_active Abandoned
- 2010-08-13 KR KR1020127003436A patent/KR20120046248A/ko not_active Withdrawn
- 2010-08-13 MX MX2012001469A patent/MX2012001469A/es not_active Application Discontinuation
- 2010-08-13 CN CN2010800346368A patent/CN102471287A/zh active Pending
- 2010-08-13 AU AU2010283713A patent/AU2010283713A1/en not_active Abandoned
- 2010-08-13 EA EA201200282A patent/EA201200282A1/ru unknown
- 2010-08-13 WO PCT/EP2010/061840 patent/WO2011018518A1/fr not_active Ceased
- 2010-08-13 EP EP10744917.5A patent/EP2464634B1/fr active Active
- 2010-08-13 JP JP2012524242A patent/JP5539519B2/ja active Active
- 2010-08-13 NZ NZ597538A patent/NZ597538A/en not_active IP Right Cessation
- 2010-08-13 BR BR112012002971A patent/BR112012002971A2/pt not_active IP Right Cessation
-
2011
- 2011-12-21 IL IL217112A patent/IL217112A0/en unknown
-
2012
- 2012-02-02 CL CL2012000278A patent/CL2012000278A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2012000278A1 (es) | 2012-10-12 |
| AU2010283713A1 (en) | 2012-02-02 |
| US8933227B2 (en) | 2015-01-13 |
| KR20120046248A (ko) | 2012-05-09 |
| TW201124385A (en) | 2011-07-16 |
| CN102471287A (zh) | 2012-05-23 |
| IL217112A0 (en) | 2012-02-29 |
| MX2012001469A (es) | 2012-02-22 |
| CA2767965A1 (fr) | 2011-02-17 |
| NZ597538A (en) | 2014-05-30 |
| EP2464634A1 (fr) | 2012-06-20 |
| JP5539519B2 (ja) | 2014-07-02 |
| EA201200282A1 (ru) | 2012-09-28 |
| US20110190499A1 (en) | 2011-08-04 |
| AR077925A1 (es) | 2011-10-05 |
| BR112012002971A2 (pt) | 2015-10-13 |
| WO2011018518A1 (fr) | 2011-02-17 |
| JP2013501759A (ja) | 2013-01-17 |
| EP2464634B1 (fr) | 2016-11-30 |
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