IN2012DN01414A - - Google Patents

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Publication number
IN2012DN01414A
IN2012DN01414A IN1414DEN2012A IN2012DN01414A IN 2012DN01414 A IN2012DN01414 A IN 2012DN01414A IN 1414DEN2012 A IN1414DEN2012 A IN 1414DEN2012A IN 2012DN01414 A IN2012DN01414 A IN 2012DN01414A
Authority
IN
India
Prior art keywords
nitroimidazooxazines
drugs
alone
novel
preparation
Prior art date
Application number
Inventor
William Alexander Denny
Andrew M Thompson
Adrian Blaser
Zhenkun Ma
Brian Desmond Palmer
Hamish Scott Sutherland
Iveta Kmentova
Original Assignee
Global Alliance For Tb Drug Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Alliance For Tb Drug Dev filed Critical Global Alliance For Tb Drug Dev
Publication of IN2012DN01414A publication Critical patent/IN2012DN01414A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
IN1414DEN2012 2009-07-31 2010-07-30 IN2012DN01414A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23039609P 2009-07-31 2009-07-31
PCT/US2010/043906 WO2011014774A1 (en) 2009-07-31 2010-07-30 Nitroimidazooxazines and their uses in anti-tubercular therapy

Publications (1)

Publication Number Publication Date
IN2012DN01414A true IN2012DN01414A (en) 2015-06-05

Family

ID=42937154

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1414DEN2012 IN2012DN01414A (en) 2009-07-31 2010-07-30

Country Status (12)

Country Link
EP (1) EP2459571B1 (en)
JP (1) JP5781072B2 (en)
KR (1) KR101746482B1 (en)
CN (1) CN102753558B (en)
AU (1) AU2010278777B2 (en)
BR (1) BR112012002278A2 (en)
CA (1) CA2769359C (en)
ES (1) ES2536997T3 (en)
IN (1) IN2012DN01414A (en)
NZ (1) NZ598121A (en)
RU (1) RU2542988C2 (en)
WO (1) WO2011014774A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
CN104059082B (en) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 Nitroimidazole heterocycle compound and the application in preparation treatment tubercular drugs thereof
KR101682356B1 (en) 2014-11-04 2016-12-06 한국화학연구원 Imidazo oxazine derivatives, pharmaceutically acceptable salts thereof or optical isomer thereof and pharmaceutical composition containing the same as an active ingredient
EP3252059A4 (en) 2015-01-29 2018-07-11 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative
CN108047248A (en) * 2018-02-12 2018-05-18 丹诺医药(苏州）有限公司 The application of oxazolidone-nitro glyoxaline coupling molecule
CN113527331B (en) * 2020-04-17 2024-05-28 南京长澳医药科技有限公司 Nitroimidazole derivative and preparation method and application thereof
CN113355439A (en) * 2021-06-07 2021-09-07 深圳市普瑞康生物技术有限公司 Novel combined detection method for latent infection and morbidity of mycobacterium tuberculosis
CN114469946B (en) * 2022-02-24 2023-10-24 首都医科大学附属北京胸科医院 Use of delamanib as CXCL10 inhibitor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK280914B6 (en) 1994-03-08 2000-09-12 American Home Products Corporation THIAZOLIDINDINATE DERIVATIVES, PHARMACEUTICAL PRODUCTS WITH THEIR CONTENT AND THEIR USE
US5668127A (en) * 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
AR041198A1 (en) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd COMPOUND 2,3-DIHIDRO-6-NITROIMIDAZO [2,1-B] OXAXOL, AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
CN100497345C (en) * 2003-10-31 2009-06-10 大塚制药株式会社 2, 3-dihydro-6-nitroimidazolo [2,1-b] oxazole compounds for the treatment of tuberculosis
DE602005004040T2 (en) 2004-01-16 2008-12-11 Sumitomo Chemical Co., Ltd. Malononitrile compounds as pesticides
TWI300409B (en) * 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
WO2006043121A1 (en) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
KR20080038369A (en) * 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 Caspase Inhibitor Prodrug
JP2009521464A (en) * 2005-12-23 2009-06-04 ノバルティス アクチエンゲゼルシャフト Nitroimidazole compounds
CN101965353B (en) * 2008-03-26 2014-12-17 丹诺医药(苏州）有限公司 Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Also Published As

Publication number Publication date
JP5781072B2 (en) 2015-09-16
KR20120084713A (en) 2012-07-30
JP2013500996A (en) 2013-01-10
AU2010278777A1 (en) 2012-03-01
WO2011014774A1 (en) 2011-02-03
CA2769359C (en) 2017-03-07
RU2012107176A (en) 2013-09-10
EP2459571A1 (en) 2012-06-06
BR112012002278A2 (en) 2020-09-15
EP2459571B1 (en) 2015-03-11
CA2769359A1 (en) 2011-02-03
KR101746482B1 (en) 2017-06-27
RU2542988C2 (en) 2015-02-27
AU2010278777B2 (en) 2015-05-07
NZ598121A (en) 2013-04-26
CN102753558B (en) 2014-10-15
CN102753558A (en) 2012-10-24
ES2536997T3 (en) 2015-06-01

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