IN2012DN02345A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02345A
IN2012DN02345A IN2345DEN2012A IN2012DN02345A IN 2012DN02345 A IN2012DN02345 A IN 2012DN02345A IN 2345DEN2012 A IN2345DEN2012 A IN 2345DEN2012A IN 2012DN02345 A IN2012DN02345 A IN 2012DN02345A
Authority
IN
India
Prior art keywords
nucleic acid
stranded
methods
tlrs
relates
Prior art date
Application number
Other languages
English (en)
Inventor
Bruce A Sullenger
Jaewoo Lee
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of IN2012DN02345A publication Critical patent/IN2012DN02345A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN2345DEN2012 2009-09-16 2010-09-16 IN2012DN02345A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24309009P 2009-09-16 2009-09-16
PCT/US2010/002516 WO2011034583A2 (fr) 2009-09-16 2010-09-16 Inhibition de l'activation des récepteurs du type toll endosomaux

Publications (1)

Publication Number Publication Date
IN2012DN02345A true IN2012DN02345A (fr) 2015-08-21

Family

ID=43759220

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2345DEN2012 IN2012DN02345A (fr) 2009-09-16 2010-09-16

Country Status (6)

Country Link
US (3) US9468650B2 (fr)
EP (1) EP2477641B1 (fr)
CN (1) CN102639142A (fr)
CA (1) CA2774460C (fr)
IN (1) IN2012DN02345A (fr)
WO (1) WO2011034583A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101702917A (zh) 2007-03-30 2010-05-05 杜克大学 一种调节核酸分子活性的方法
US9468650B2 (en) 2009-09-16 2016-10-18 Duke University Inhibition of endosomal toll-like receptor activation
US9687529B2 (en) 2011-05-05 2017-06-27 Duke University Method of controlling coagulation
WO2014169043A1 (fr) * 2013-04-09 2014-10-16 Duke University Agents anti-inflammatoires et leurs procédés d'utilisation
WO2015161094A1 (fr) 2014-04-16 2015-10-22 Duke University Nanofibres cationiques électrofilées et procédés pour leur fabrication et leur utilisation
WO2017079537A1 (fr) 2015-11-04 2017-05-11 Duke University Polymères polycationiques destinés à être utilisés dans le traitement et la détection du cancer
WO2018053427A1 (fr) 2016-09-16 2018-03-22 Duke University Agents ciblant le facteur de von willebrand (vwf) et leurs procédés d'utilisation
US12447464B2 (en) 2016-12-22 2025-10-21 Duke University Polycationic microfibers and methods of using the same
EP3601592A4 (fr) 2017-03-23 2020-11-25 Duke University Inversion médiée par antidote de coloration d'aptamère extracellulaire
WO2018222484A1 (fr) * 2017-05-30 2018-12-06 The Trustees Of Columbia University In The City Of New York Piégeur d'acide nucléique cationique et ses utilisations
EP3678708A4 (fr) 2017-09-08 2021-12-08 Duke University Aptamères de ciblage de nucléoline et leurs procédés d'utilisation
WO2021016924A1 (fr) * 2019-07-31 2021-02-04 中山大学 Polymère cationique et particules utilisables pour traiter le psoriasis
EP4249913A1 (fr) * 2022-03-22 2023-09-27 Centre Hospitalier Universitaire de Nîmes Inhibiteur du récepteur de type toll 3 pour la prévention et/ou le traitement de troubles chez des patients ayant des antécédents personnels de thromboembolie veineuse (vte)

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919761A (en) 1992-08-14 1999-07-06 The Board Of Regents Of The University Of Michigan Peptides for heparin and low molecular weight heparin anticoagulation reversal
US6037329A (en) 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
US6624141B1 (en) 1999-03-17 2003-09-23 The Regents Of The University Of Michigan Protamine fragment compositions and methods of use
JP2004508023A (ja) 2000-09-08 2004-03-18 インビトロジェン　コーポレイション 核酸合成の感度および特異性を増強するための化合物および方法
USRE43612E1 (en) 2000-10-10 2012-08-28 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
WO2002053185A2 (fr) * 2001-01-05 2002-07-11 Intercell Ag Utilisations de composes polycationiques
BR0207905A (pt) 2001-03-08 2004-07-27 Merck Patent Ges Mit Beschroen Protamina modificada com imunogenicidade reduzida
EP2070939B1 (fr) 2001-05-25 2014-04-02 Duke University Modulateurs d'agents pharmacologiques
AUPR604101A0 (en) 2001-06-29 2001-07-26 Unisearch Limited Aptamers
US20050136040A1 (en) 2001-10-11 2005-06-23 Imperial College Innovations Limited Control of gene expression using a complex of an oligonucleotide and a regulatory peptide
US20040063654A1 (en) 2001-11-02 2004-04-01 Davis Mark E. Methods and compositions for therapeutic use of RNA interference
AU2002368202B2 (en) 2001-11-02 2008-06-05 Insert Therapeutics, Inc Methods and compositions for therapeutic use of RNA interference
US20030180250A1 (en) 2002-03-22 2003-09-25 Council Of Scientific And Industrial Research Compositions and complexes containing a macromolecular compound as potential anti-inflammatory agents
WO2004032862A2 (fr) 2002-10-09 2004-04-22 Insert Therapeutics, Inc. Materiaux et compositions a base de cyclodextrine, et utilisations correspondantes
US20050256071A1 (en) 2003-07-15 2005-11-17 California Institute Of Technology Inhibitor nucleic acids
US20050136430A1 (en) 2003-07-15 2005-06-23 California Institute Of Technology Inhibitor nucleic acids
KR101185050B1 (ko) 2004-04-22 2012-10-04 레가도 바이오사이언스, 인코포레이티드 응고 인자의 개선된 모듈레이터
US8080245B2 (en) * 2004-08-04 2011-12-20 University Of Massachusetts Anti-pathogen immunoadhesins
GB0422877D0 (en) 2004-10-14 2004-11-17 Univ Glasgow Bioactive polymers
ATE541928T1 (de) 2005-03-31 2012-02-15 Calando Pharmaceuticals Inc Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen
US7611835B2 (en) 2005-09-30 2009-11-03 Battelle Memorial Institute Process for preparing multilayer enzyme coating on a fiber
WO2007070682A2 (fr) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology Systeme de criblage de particules
WO2007140000A2 (fr) 2006-05-26 2007-12-06 Regado Biosciences, Inc. Administration du système d'anticoagulation reg1
EP2035041B1 (fr) * 2006-06-30 2020-01-08 Syntab Therapeutics GmbH Conjugués pour l'immunothérapie innée anticancéreuse
WO2008066621A2 (fr) 2006-10-19 2008-06-05 Duke University Inhibition de plaquettes réversible
WO2008063157A2 (fr) * 2006-10-25 2008-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anticoagulant à base de nanoparticules
AU2008216669B2 (en) * 2007-02-15 2013-12-12 Mannkind Corporation A method for enhancing T cell response
CN101702917A (zh) * 2007-03-30 2010-05-05 杜克大学 一种调节核酸分子活性的方法
KR20100082840A (ko) 2007-09-27 2010-07-20 에스체아 히기에너 프로덕츠 악티에볼라그 클레이결합된 폴리머 겔
WO2009064767A2 (fr) 2007-11-12 2009-05-22 Massachusetts Institute Of Technology Nanofibres bactéricides et procédés d'utilisation
WO2010020008A1 (fr) 2008-08-22 2010-02-25 Polymers Crc Limited Revêtements polymères
US8992991B2 (en) 2009-05-15 2015-03-31 The Johns Hopkins University Multicomponent degradable cationic polymers
US9468650B2 (en) 2009-09-16 2016-10-18 Duke University Inhibition of endosomal toll-like receptor activation
WO2012088059A2 (fr) 2010-12-20 2012-06-28 Virginia Commonwealth University Procédé facile de réticulation et d'incorporation de molécules bioactives dans des échafaudages de fibres électrofilées
WO2013040552A2 (fr) 2011-09-16 2013-03-21 Georgia Health Sciences University Procédés permettant de favoriser la tolérance immunitaire

Also Published As

Publication number Publication date
US9468650B2 (en) 2016-10-18
US20230248805A1 (en) 2023-08-10
US20170095503A1 (en) 2017-04-06
EP2477641A4 (fr) 2013-08-07
WO2011034583A3 (fr) 2011-10-06
CA2774460C (fr) 2016-08-09
US11617779B2 (en) 2023-04-04
CN102639142A (zh) 2012-08-15
EP2477641B1 (fr) 2024-03-27
EP2477641A2 (fr) 2012-07-25
CA2774460A1 (fr) 2011-03-24
US20120183564A1 (en) 2012-07-19
WO2011034583A2 (fr) 2011-03-24

Similar Documents

Publication Publication Date Title
WO2011034583A3 (fr) Inhibition de l'activation des récepteurs du type toll endosomaux
WO2020198509A3 (fr) Oligonucléotides modifiés à stabilité accrue
EP2569453A4 (fr) Méthodes d'isolement de l'acide nucléique
BR112014005205A2 (pt) métodos para etiquetar bibliotecas codificadas com dna
WO2007136736A3 (fr) Procédés de tri et de synthèse d'acides nucléiques
MX2010002113A (es) Metodos para detectar oligonucleotidos.
WO2006029258A3 (fr) Chimie medicale utilisant des aptameres
WO2009012363A3 (fr) Nucléotides et aptamères contenant des groupes acide boronique ayant une liaison sollicitée à des protéines glycosylées et leurs utilisations
IL190501A0 (en) Multicomponent nucleic acid enzymes and methods for their use
WO2010026488A3 (fr) Procédés et kits de séquençage d'acides nucléiques
EP1994142A4 (fr) Procédés et compositions permettant d'isoler rapidement de petites molécules d'arn
BR112014007852A2 (pt) nucleosídeos, nucleotídeos e ácidos nucleicos modificados e usos dos mesmos
IN2014DN03463A (fr)
WO2008063203A3 (fr) Compositions et méthodes de silençage efficace de gènes dans des végétaux
WO2008061537A3 (fr) Oligonucléotides pour moduler l'activité d'arn cible
WO2008151631A3 (fr) Utilisation de courts oligonucléotides pour des expériences à redondance de réactif dans une analyse fonctionnelle d'arn
WO2005097993A3 (fr) Oligonucleotides d'arn viral immunostimulateurs
WO2010141511A3 (fr) Polynucléotides pour interférence arn multivalente, compositions et procédés pour les utiliser
AR067135A1 (es) Metodos para aislar arn de fragmento largo de muestras fijas
ATE534737T1 (de) Gezielte abgabe von sirna
AU2014219019A8 (en) Short interfering nucleic acid (siNA) molecules containing a 2' internucleoside linkage
EE200200051A (et) Tenastsiin C nukleiinhappelised ligandid
BR112014021993A2 (pt) detecção da variação de nucleotídeo em sequência de ácido nucleico alvo através de ensaio de clivagem e extensão de pto
WO2011056073A3 (fr) Composés inédits capables de moduler la néovascularisation et méthodes de traitement faisant appel à ces composés
IN2014CN03921A (fr)