IN2012DN02485A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02485A
IN2012DN02485A IN2485DEN2012A IN2012DN02485A IN 2012DN02485 A IN2012DN02485 A IN 2012DN02485A IN 2485DEN2012 A IN2485DEN2012 A IN 2485DEN2012A IN 2012DN02485 A IN2012DN02485 A IN 2012DN02485A
Authority
IN
India
Prior art keywords
rheumatoid arthritis
methods
therapeutic agents
identifying
diagnosing
Prior art date
Application number
Inventor
Jr Glynn Dennis
Flavius Martin
Michael J Townsend
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IN2012DN02485A publication Critical patent/IN2012DN02485A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rehabilitation Therapy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Methods of identifying, diagnosing, and prognosing rheumatoid arthritis are provided, as well as methods of treating rheumatoid arthritis. Also provided are methods for identifying effective rheumatoid arthritis therapeutic agents and predicting responsiveness to rheumatoid arthritis therapeutic agents.
IN2485DEN2012 2009-09-03 2010-09-02 IN2012DN02485A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27594809P 2009-09-03 2009-09-03
US25242409P 2009-10-16 2009-10-16
PCT/US2010/047734 WO2011028945A1 (en) 2009-09-03 2010-09-02 Methods for treating, diagnosing, and monitoring rheumatoid arthritis

Publications (1)

Publication Number Publication Date
IN2012DN02485A true IN2012DN02485A (en) 2015-08-28

Family

ID=43625246

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2485DEN2012 IN2012DN02485A (en) 2009-09-03 2010-09-02

Country Status (11)

Country Link
US (2) US8728730B2 (en)
EP (2) EP2473637B1 (en)
JP (3) JP5996429B2 (en)
KR (1) KR20120104517A (en)
CN (2) CN102597268B (en)
BR (1) BR112012004777A2 (en)
CA (1) CA2772929A1 (en)
IN (1) IN2012DN02485A (en)
MX (2) MX2012002766A (en)
RU (2) RU2539112C2 (en)
WO (1) WO2011028945A1 (en)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1692182E (en) 2003-11-05 2010-05-13 Roche Glycart Ag Cd20 antibodies with increased fc receptor binding affinity and effector function
TW201438738A (en) * 2008-09-16 2014-10-16 建南德克公司 Method for treating progressive multiple sclerosis
BR112012004777A2 (en) 2009-09-03 2019-09-24 Genentech Inc Methods to Treat Diagnose and Monitor Rheumatoid Arthritis
EP2525822B1 (en) 2010-01-20 2017-05-10 Merck Sharp & Dohme Corp. Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
WO2011091177A1 (en) 2010-01-20 2011-07-28 Tolerx, Inc. Anti-ilt5 antibodies and ilt5-binding antibody fragments
EP3409289B1 (en) 2010-02-26 2020-09-30 Novo Nordisk A/S Stable antibody containing compositions
EA201291181A1 (en) 2010-05-06 2013-05-30 Новартис Аг COMPOSITIONS AND METHODS OF APPLICATION OF THERAPEUTIC POLYVALENT ANTIBODIES AGAINST PROTEIN RELATED TO LOW DENSITY 6 LIPOPROTEIN RECEPTOR (LRP6)
CA2798432A1 (en) 2010-05-06 2011-11-10 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
RU2012153786A (en) 2010-05-28 2014-07-10 Ново Нордиск А/С STABLE MULTI-DOSE COMPOSITIONS CONTAINING ANTIBODY AND CONSERVANT
EP3786185A1 (en) 2010-12-06 2021-03-03 Seagen Inc. Humanized antibodies to liv-1 and use of same to treat cancer
JP5885926B2 (en) * 2011-01-28 2016-03-16 シスメックス株式会社 Method for evaluating the presence of rheumatoid arthritis and biomarker set used in the method
WO2012118750A2 (en) 2011-02-28 2012-09-07 Genentech, Inc. Biological markers and methods for predicting response to b-cell antagonists
WO2012167186A1 (en) * 2011-06-02 2012-12-06 Health Datastream Inc. System and method for scoring illness complexity to predict healthcare cost
KR20140091031A (en) 2011-11-04 2014-07-18 노파르티스 아게 Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs
KR20140124767A (en) 2012-02-10 2014-10-27 노보 노르디스크 에이/에스 Methods related to treatment of inflammatory diseases and disorders
WO2013135789A1 (en) * 2012-03-15 2013-09-19 Universiteit Hasselt Means and methods for the determination of the joint destruction progression rate in rheumatoid arthritis patients
WO2013164440A1 (en) 2012-05-03 2013-11-07 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2014028374A1 (en) * 2012-08-17 2014-02-20 Eli Lilly And Company Biomarkers predictive of rheumatoid arthritis or systemic lupus erythematosus response to anti-baff antibody therapy
US20150376701A1 (en) * 2013-01-31 2015-12-31 The University Of Birmingham Biomarkers of autoimmune and/or chronic diseases associated with joint inflammation
EP2813850A1 (en) * 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting rheumatoid arthritis treatment response
US20160274106A1 (en) * 2013-06-21 2016-09-22 Catholic University Industry-Academic Cooperation Foundation Biomarker for rheumatoid arthritis diagnosis or activity evaluation
TWI725931B (en) 2013-06-24 2021-05-01 美商建南德克公司 Anti-fcrh5 antibodies
CN103399147B (en) * 2013-08-07 2015-06-17 苏州大学 Polygalacturonic acid novel application
KR101628035B1 (en) * 2013-09-13 2016-06-09 인제대학교 산학협력단 Method for screening therapeutic agents of ovarian cancer using VSIG4
CN103513040B (en) * 2013-10-16 2015-03-11 常晓天 Application of protein CD38 to preparation of rheumatoid arthritis diagnosing marker
EP2863231A1 (en) * 2013-10-17 2015-04-22 Institut D'Investigaciones Biomédiques August Pi i Sunyer Diagnostic method for detecting a GABA(A) related autoimmune disease and related subject-matter
BR112016020987B1 (en) 2014-03-12 2023-11-14 Western Sydney Local Health District RENAL ALLOGRAFT RECEPTOR IDENTIFICATION METHOD AND RENAL ALLOGRAFT RECEPTOR SELECTION METHOD
RU2554755C1 (en) * 2014-05-26 2015-06-27 Федеральное бюджетное учреждение науки "Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера" (ФБУН НИИ эпидемиологии и микробиологии имени Пастера) Diagnostic technique for rheumatoid arthritis
WO2015200887A2 (en) 2014-06-26 2015-12-30 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
KR20160048442A (en) * 2014-10-24 2016-05-04 가톨릭대학교 산학협력단 Biomarkers related to rheumatoid arthritis
CA2971315C (en) 2015-01-29 2023-02-14 Ares Trading S.A. Immunoassays for high positively charged proteins
CN105988009B (en) * 2015-02-28 2018-03-13 复旦大学附属华山医院 Purposes of the Netrin 4 in the preparation of detection stomach cancer and prognostic marker is prepared
US20180120329A1 (en) * 2015-03-25 2018-05-03 La Jolla Institute For Allergy And Immunology Cxcl13 as an indicator of germinal activity and immune response
JP6663000B2 (en) * 2015-05-12 2020-03-11 ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル Autoantigens for the diagnosis of rheumatoid arthritis
HRP20231134T1 (en) 2015-06-16 2024-01-05 F. Hoffmann - La Roche Ag HUMANIZED AND AFFINITY MATURED ANTIBODIES TO FCRH5 AND METHODS OF USE
CN105200159B (en) * 2015-11-06 2018-06-15 北京致成生物医学科技有限公司 Osteoarthritis diagnosis and treatment reagent and its application
GB201521357D0 (en) * 2015-12-03 2016-01-20 Univ Liverpool Methods for predicting response to anti-TNF therapy
AU2017235545A1 (en) 2016-03-15 2018-10-25 Seagen Inc. Combination therapy using a LIV1-ADC and a chemotherapeutic
WO2017181038A1 (en) * 2016-04-15 2017-10-19 Rowan University Serum biomarkers for predicting and evaluating response to tnf inhibitor therapy in rheumatoid arthritis patients
US20170321286A1 (en) 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
US10908159B2 (en) 2016-06-07 2021-02-02 The General Hospital Corporation Identification of a T cell epitope of Prevotella copri that induces T cell responses in patients with Rheumatoid arthritis
RU2622597C1 (en) * 2016-07-05 2017-06-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Method for joint pain syndrome prediction for patients with signs of connective tissue dysplasia
GB201616557D0 (en) * 2016-09-29 2016-11-16 Secretary Of State For Health The Assay for distinguishing between sepsis and systemic inflammatory response syndrome
CN106526196B (en) * 2016-10-08 2018-08-10 北京大学人民医院 Applications of the SR-A as Diagnosis of Rheumatoid Arthritis marker and intervention target spot
EP3539978B1 (en) * 2016-11-09 2025-02-26 ICM Co., Ltd. Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient
KR20190074300A (en) 2016-11-15 2019-06-27 제넨테크, 인크. Dosage for treatment with anti-CD20 / anti-CD3 bispecific antibodies
KR102588627B1 (en) * 2017-03-08 2023-10-16 김성진 Composition for preparing extracellular matrix using MAST4 gene and method for preparing the same
WO2018164507A2 (en) * 2017-03-08 2018-09-13 주식회사 길로 Extracellular matrix-producing composition using mast4 gene and preparation method therefor
US11325969B2 (en) * 2017-08-29 2022-05-10 Veritas Therapeutics Inc. FGL2 antibodies and binding fragments thereof and uses thereof
MX389484B (en) * 2017-11-13 2025-03-20 The Multiple Myeloma Res Foundation Inc Integrated, molecular, omics, immunotherapy, metabolic, epigenetic, and clinical database
EP3728638B1 (en) * 2018-01-24 2024-11-13 Genentech, Inc. Diagnostic and therapeutic methods for the treatment of rheumatoid arthritis (ra)
CN108359726B (en) * 2018-02-28 2020-09-04 固安博健生物技术有限公司 Application of CORO2B as molecular diagnosis and treatment marker
EP3765634A4 (en) 2018-03-16 2021-12-01 Scipher Medicine Corporation METHODS AND SYSTEMS FOR PREDICTING RESPONSE TO ANTI-TNF THERAPIES
JP7576754B2 (en) 2018-04-11 2024-11-01 スペースクラフト セブン リミテッド ライアビリティ カンパニー Compositions and methods for stem cell transplantation
US11572589B2 (en) 2018-04-16 2023-02-07 Icahn School Of Medicine At Mount Sinai Method for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood
US20190336585A1 (en) * 2018-05-03 2019-11-07 John Lawrence Mee Method for sustainable human cognitive enhancement
US20190359985A1 (en) * 2018-05-22 2019-11-28 John Lawrence Mee Adjustable method for sustainable human cognitive enhancement
CN109142729B (en) * 2018-06-14 2021-04-23 郑州大学第一附属医院 A kind of lung cancer marker anti-HMGB3 autoantibody and its application
CN112714673B (en) * 2018-06-21 2023-04-21 阿斯特拉维斯公司 Microfluidic device and method for processing microparticles
US20190390193A1 (en) * 2018-06-23 2019-12-26 John Lawrence Mee Reversible method for sustainable human cognitive enhancement
US10723191B1 (en) 2018-07-01 2020-07-28 Softwheel Ltd. In-wheel three-arm suspension for vehicles
CN110917351A (en) * 2018-09-20 2020-03-27 华中科技大学同济医学院附属同济医院 Use of MBD2 inhibitors in the prevention and treatment of fibrotic diseases
US20210382050A1 (en) * 2018-10-19 2021-12-09 The Regents Of The University Of Michigan Method for monitoring autoimmune disease
CN109207584A (en) * 2018-11-01 2019-01-15 固安博健生物技术有限公司 Application of the MARCO as the molecular marker of early diagnosis osteoarthritis
WO2020163876A1 (en) * 2019-02-08 2020-08-13 The Regents Of The University Of California Compositions and methods involving layilin
EP3962901A1 (en) 2019-04-29 2022-03-09 Solent Therapeutics, LLC 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2
AU2020267504A1 (en) 2019-05-08 2021-12-02 Janssen Biotech, Inc. Materials and methods for modulating T cell mediated immunity
GB2603294A (en) 2019-06-27 2022-08-03 Scipher Medicine Corp Developing classifiers for stratifying patients
CN110456074B (en) * 2019-08-27 2022-06-03 广东菲鹏生物有限公司 Citrullinated peptides and their applications, detection reagents and kits for rheumatoid arthritis
CN110408590B (en) * 2019-09-06 2022-10-25 遵义医学院附属医院 Method for inducing differentiation of human mesenchymal stem cells into osteoblasts and application thereof
GB201914079D0 (en) * 2019-09-30 2019-11-13 Univ London Queen Mary Method of predicting requirement for biologic therapy
KR102596937B1 (en) * 2019-11-07 2023-11-03 가톨릭대학교 산학협력단 Biomarker for diagnosing pannus of rheumatoid arthritis and use thereof
CN111091909B (en) * 2019-11-26 2022-05-31 中国信息通信研究院 Medical image identification method and device
CN113122628B (en) * 2019-12-30 2023-08-11 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） Application of CLEC5A gene as a marker in the diagnosis and treatment of endometrial cancer
EP4088117A1 (en) * 2020-01-10 2022-11-16 SomaLogic Operating Co., Inc. Methods of determining impaired glucose tolerance
IL298171A (en) 2020-05-14 2023-01-01 Ampel Biosolutions Llc Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
CN112114126B (en) * 2020-08-13 2023-03-24 川北医学院 Diagnostic marker for systemic lupus erythematosus and application thereof
EP4217508B1 (en) * 2020-09-22 2026-01-28 The Secretary Of State For Defence Apparatus, kits and methods for predicting the development of sepsis
TW202233674A (en) 2020-10-28 2022-09-01 美商健生生物科技公司 Compositions and methods for modulating delta gamma chain mediated immunity
TWI874719B (en) 2020-11-04 2025-03-01 美商建南德克公司 Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
AU2021374590A1 (en) 2020-11-04 2023-06-01 Genentech, Inc. Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
KR20230095113A (en) 2020-11-04 2023-06-28 제넨테크, 인크. Dosing for Treatment with Anti-CD20/Anti-CD3 Bispecific Antibodies and Anti-CD79B Antibody Drug Conjugates
CN112646887B (en) * 2020-12-23 2023-02-28 广州医科大学附属第五医院 ZNF239 as a target for diagnosis and treatment of liver cancer
CN112946269B (en) * 2020-12-29 2022-12-27 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） Application of ABCA1 and CD68 as prognosis markers in preparation of liver cancer prognosis prediction kit
GB202103241D0 (en) * 2021-03-09 2021-04-21 Univ Oxford Innovation Ltd Biomaker
CN113186281B (en) * 2021-04-02 2023-02-28 广州医科大学附属第五医院 INAVA as a marker for hepatocellular carcinoma
CN113512582A (en) * 2021-04-15 2021-10-19 上海鸿准生物医药科技有限公司 Application of SLC22A18 in allergic and inflammatory diseases
WO2022223667A1 (en) * 2021-04-21 2022-10-27 Sorbonne Universite Markers of autoimmune diseases
CN113307835B (en) * 2021-04-21 2022-12-13 南通大学 siRNA and application thereof in preparation of chronic pain treatment medicine
WO2022228705A1 (en) 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
KR20240007171A (en) 2021-05-14 2024-01-16 제넨테크, 인크. Methods for treating CD20 positive proliferative disorders using mosunetuzumab and polatuzumab vedotin
WO2022264134A1 (en) * 2021-06-13 2022-12-22 Technion Research & Development Foundation Limited Method for determining suitability to anti-tnf alpha therapy
EP4433506A1 (en) 2021-11-16 2024-09-25 Genentech, Inc. Methods and compositions for treating systemic lupus erythematosus (sle) with mosunetuzumab
WO2023158713A1 (en) * 2022-02-16 2023-08-24 Ampel Biosolutions, Llc Unsupervised machine learning methods
CN114994327B (en) * 2022-04-12 2025-04-15 浙江大学医学院附属第二医院 Application of a biomarker GSDME
EP4619005A2 (en) * 2022-11-18 2025-09-24 The United States Government As Represented By The Department Of Veterans Affairs Methods for treating rheumatoid arthritis using a syndecan-1 inhibitor or a syntenin-1 inhibitor
CN116144761A (en) * 2023-02-24 2023-05-23 山西医科大学 Construction method and application of rheumatoid arthritis diagnosis classifier
CN116064784A (en) * 2023-03-23 2023-05-05 上海市光华中西医结合医院 Application of FGF10 in preparation of kit for detecting rheumatoid arthritis
JP2024179174A (en) * 2023-06-14 2024-12-26 シスメックス株式会社 Method for obtaining information regarding efficacy of chemotherapy for patients with membranous nephropathy, method for assisting in determining efficacy of chemotherapy for patients with membranous nephropathy, and reagent kit
TWI901424B (en) * 2023-11-10 2025-10-11 長庚醫療財團法人林口長庚紀念醫院 Use of anti-PDGFRL neutralizing antibodies in the treatment of arthritis
CN117567626B (en) * 2024-01-15 2024-04-26 北京大学人民医院 An anti-citrullinated scavenger receptor A polypeptide antibody and its application in preparing a product for diagnosing rheumatoid arthritis
WO2025184328A1 (en) * 2024-02-28 2025-09-04 Acurex Biosciences Corporation Polypeptides binding to miro1
WO2025218746A1 (en) * 2024-04-17 2025-10-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis
WO2025228323A1 (en) * 2024-04-29 2025-11-06 洪明奇 Method for evaluating therapeutic response of rheumatoid arthritis patient to janus kinase inhibitor by using gene variation as biomarker
CN119424633B (en) * 2024-11-07 2025-07-25 浙江赛尔共银生物科技有限公司 Composition containing mesenchymal stem cells for treating degenerative arthritis and preparation method thereof

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434227A (en) 1982-02-08 1984-02-28 Abbott Laboratories Immunoassay for class specific immunoglobulin antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA1261257A (en) 1984-09-19 1989-09-26 Helgi Valdimarsson Prognostic value of rheumatoid factor isotypes and their association with disease activity
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
ES2284161T3 (en) 1990-01-12 2007-11-01 Amgen Fremont Inc. GENERATION OF XENOGENIC ANTIBODIES.
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE255131T1 (en) 1991-06-14 2003-12-15 Genentech Inc HUMANIZED HEREGULIN ANTIBODIES
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5484892A (en) 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
EP0811059A4 (en) 1995-02-08 1998-04-01 Human Genome Sciences Inc BETA-11 HUMAN CHEMOKINE AND ALPHA-1 HUMAN CHEMOKINE
US6139832A (en) 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
KR19990022283A (en) 1995-06-05 1999-03-25 벤슨 로버트 에이치. Human Chemokine Beta-11 and Human Chemokine Alpha-1
ATE267610T1 (en) 1996-03-20 2004-06-15 Immunomedics Inc GLYCOSYLATED IGG ANTIBODIES
DK0939804T4 (en) 1996-10-25 2011-07-18 Human Genome Sciences Inc Neutrokine-alpha
ATE549918T1 (en) 1996-12-03 2012-04-15 Amgen Fremont Inc HUMAN ANTIBODIES THAT EXPRESSLY BIND HUMAN TNF ALPHA
WO1998027114A2 (en) 1996-12-17 1998-06-25 Schering Corporation Mammalian cell surface antigens; related reagents
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
CA2232743A1 (en) 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
IL134480A0 (en) 1997-09-12 2001-04-30 Apotech Sa Kay - an immune system protein and dna sequences encoding the same
EP1033134B8 (en) * 1997-10-29 2007-09-19 Otsuka Pharmaceutical Co., Ltd. Compositions inhibiting smooth muscle proliferation and method for the diagnosis of arteriosclerosis
US6110695A (en) 1997-12-02 2000-08-29 The Regents Of The University Of California Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
IL138608A0 (en) 1998-04-02 2001-10-31 Genentech Inc Antibody variants and fragments thereof
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
TR200101998T2 (en) 1999-01-07 2002-06-21 Zymogenetics, Inc. Soluble receptor BR 43x2 and methods of use
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
KR100940380B1 (en) 1999-01-15 2010-02-02 제넨테크, 인크. Polypeptide Variants with Altered Effector Function
EP1194167B1 (en) 1999-06-09 2009-08-19 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target b-cells
PL211786B1 (en) 1999-08-17 2012-06-29 Apoxis Sa Application of an antibody and a polypeptide
DE10041402A1 (en) 2000-08-23 2002-03-14 Morphochem Ag Novel compounds that inhibit factor Xa activity
ES2243301T3 (en) * 1999-09-01 2005-12-01 Boehringer Ingelheim Pharmaceuticals Inc. COMPOUNDS TO TREAT IMMUNE AUTO DISEASES CONTAINING A COMPOUND THAT INHIBITES THE ICAM-LFA-1 INTERACTION AND A COMPOUND THAT INHIBITES THE CD40 INTERACTION.
US7105149B1 (en) 1999-11-29 2006-09-12 The Trustees Of Columbia University In The City Of New York Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
DE60128216T2 (en) 2000-05-12 2008-01-10 Amgen Inc., Thousand Oaks Polypeptides for inhibiting the April-mediated proliferation of B and T cells
AU2001268427B2 (en) 2000-06-16 2007-03-29 Glaxosmithkline Intellectual Property Limited Antibodies that immunospecifically bind to blys
AU2001285066B2 (en) 2000-08-18 2006-06-29 Human Genome Sciences, Inc. Binding polypeptides for B lymphocyte stimulator protein (BLYS)
UA83458C2 (en) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. The isolated polypeptide baff-r (the receptor of the factor of activation of b-cells of the family tnf)
JP2004516826A (en) 2000-11-07 2004-06-10 ザイモジェネティクス，インコーポレイティド Human tumor necrosis factor receptor
CA2438682A1 (en) 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
US6818406B2 (en) 2001-03-23 2004-11-16 Mayo Foundation For Medical Education And Research Rheumatoid arthritis markers
HU229910B1 (en) 2001-05-11 2014-12-29 Amgen Inc Thousand Oaks Peptides and related molecules that bind to tall-1
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
CA2453995A1 (en) 2001-08-03 2003-02-20 Genentech, Inc. Tacis and br3 polypeptides and uses thereof
WO2003024991A2 (en) 2001-09-21 2003-03-27 Amgen Inc. Tall-1 receptor molecules and uses thereof
CA2465268A1 (en) 2001-10-24 2003-05-01 National Jewish Medical And Research Center Three-dimensional structures of tall-1 and its cognate receptors and modified proteins and methods related thereto
WO2003072827A1 (en) * 2001-10-31 2003-09-04 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
US20030224386A1 (en) 2001-12-19 2003-12-04 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of rheumatoid arthritis
RU2004127458A (en) 2002-02-14 2005-10-27 Иммуномедикс, Инк. (Us) ANTI-CD20 ANTIBODIES, THEIR HYBRID PROTEINS AND WAYS OF THEIR USE
DE60334364D1 (en) 2002-02-21 2010-11-11 Univ California TREATMENT PROCEDURE USING ANTI-CD22 ANTIBODIES
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
BR0312767A (en) 2002-07-18 2005-05-03 Perini Fabio Spa Storage unit for elongated products
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
KR20110017020A (en) 2002-10-17 2011-02-18 젠맵 에이/에스 Human monoclonal antibodies against CD20
EP1944320A1 (en) 2002-12-16 2008-07-16 Genentech, Inc. Immunoglobulin variants and uses thereof
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
SE0300959D0 (en) * 2002-12-19 2003-04-02 Pharmacia Ab Methods for predicting therapeutic response to agents acting on the growth hormone receptor
PT2272868E (en) 2003-06-05 2015-07-07 Genentech Inc Combination therapy for b cell disorders
US20050163775A1 (en) 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
IL156495A0 (en) 2003-06-17 2004-01-04 Prochon Biotech Ltd Use of fgfr3 antagonists for treating t cell mediated diseases
US20060094056A1 (en) 2003-09-15 2006-05-04 Oklahoma Medical Research Foundation Method of using cytokine assays to diagnose treat, and evaluate inflammatory and autoimmune diseases
DE102004016437A1 (en) 2004-04-04 2005-10-20 Oligene Gmbh Method for detecting signatures in complex gene expression profiles
CA2501422C (en) 2004-04-29 2014-08-12 University Of Rochester Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
CA2568336A1 (en) 2004-06-04 2005-12-22 Genentech, Inc. Method for treating lupus
US7999077B2 (en) 2004-09-30 2011-08-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services IRTA2 antibodies and methods of use
RU2411956C2 (en) 2004-10-05 2011-02-20 Дженентек, Инк. Method of treating vasculitis
US20070105133A1 (en) 2005-06-13 2007-05-10 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
BRPI0614183A2 (en) * 2005-07-25 2011-03-15 Trubion Pharmaceuticals Inc single-dose use of cd20-specific binding molecules
CN101262876A (en) 2005-08-09 2008-09-10 酶遗传学股份有限公司 Method of treating B cell malignancies with TACI-IG fusion molecules
WO2007038501A2 (en) 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers
AU2006294477A1 (en) * 2005-09-27 2007-04-05 Source Mdx Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
EP2005279A2 (en) 2006-03-15 2008-12-24 Koninklijke Philips Electronics N.V. Remote control pointing technology with roll detection
GB0607774D0 (en) 2006-04-20 2006-05-31 Renovo Group Plc Medicaments
RU2449808C2 (en) 2006-04-21 2012-05-10 Сентокор, Инк. Cxcl13 antagonists and application thereof for treating inflammatory diseases
EP1857559A1 (en) 2006-05-16 2007-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for predicting responsiveness to TNF alpha blocking agents
US20080227655A1 (en) * 2006-05-16 2008-09-18 Michael Bevilacqua Assessment of effect of an agent on a human biological condition using rodent gene expression panels
US20070269827A1 (en) * 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
WO2008156494A1 (en) * 2006-11-03 2008-12-24 The Johns Hopkins University Use of high-dose oxazaphosphorine drugs in combination with monoclonal antibodies for treating immune disorders
WO2008056198A1 (en) 2006-11-09 2008-05-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for predicting therapeutic responsiveness to tnf-alpha blocking agents
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
US20080199481A1 (en) 2007-02-21 2008-08-21 Astrazeneca Ab Compounds
EP2132343B1 (en) 2007-03-01 2012-08-29 Université Catholique de Louvain Method for the determination and the classification of rheumatic conditions
WO2008121940A1 (en) 2007-03-30 2008-10-09 Centocor, Inc. Cxcl13 antagonists and their use for the treatment of inflammatory diseases
AR065910A1 (en) * 2007-04-02 2009-07-08 Genentech Inc FORECAST BIOLOGICAL MARKERS OF THE RESPONSE OF THE Rheumatoid ARTHRITIS TO THE ANTAGONISTS OF THE LYMPHOCYTES B
WO2008132176A2 (en) 2007-04-27 2008-11-06 Universite Catholique De Louvain Method for evaluating the response of an individual to tnf blocking therapy
MX2009013410A (en) 2007-06-08 2010-03-22 Biogen Idec Inc Biomarkers for predicting anti-tnf responsiveness or non-responsiveness.
EP2255195A2 (en) 2007-09-03 2010-12-01 Protagen AG Marker sequences for rheumatoid arthritis and use thereof
WO2009102366A2 (en) * 2007-11-19 2009-08-20 Wyeth Expression of orphan gpr64 in inflammatory diseases
US8121883B2 (en) * 2008-02-07 2012-02-21 International Business Machines Corporation Method and system for automatically prioritizing opportunity based customer requirements
CA2757382A1 (en) 2009-04-01 2010-10-21 Kristi Elkins Anti-fcrh5 antibodies and immunoconjugates
BR112012004777A2 (en) 2009-09-03 2019-09-24 Genentech Inc Methods to Treat Diagnose and Monitor Rheumatoid Arthritis

Also Published As

Publication number Publication date
JP2017000141A (en) 2017-01-05
US8728730B2 (en) 2014-05-20
MX353186B (en) 2018-01-05
RU2014145058A (en) 2016-05-27
RU2539112C2 (en) 2015-01-10
CN107385034B (en) 2021-08-17
US20140341887A1 (en) 2014-11-20
US20110052488A1 (en) 2011-03-03
EP3211094A2 (en) 2017-08-30
JP2021019594A (en) 2021-02-18
CA2772929A1 (en) 2011-03-11
CN107385034A (en) 2017-11-24
EP2473637B1 (en) 2017-03-29
JP5996429B2 (en) 2016-09-21
EP2473637A1 (en) 2012-07-11
EP3211094A3 (en) 2017-11-01
BR112012004777A2 (en) 2019-09-24
HK1245341A1 (en) 2018-08-24
CN102597268A (en) 2012-07-18
CN102597268B (en) 2017-09-22
US9822400B2 (en) 2017-11-21
MX2012002766A (en) 2012-04-02
JP2013503643A (en) 2013-02-04
JP6895718B2 (en) 2021-06-30
WO2011028945A1 (en) 2011-03-10
EP2473637A4 (en) 2013-05-01
KR20120104517A (en) 2012-09-21
RU2012112822A (en) 2013-10-10

Similar Documents

Publication Publication Date Title
MX2012002766A (en) Methods for treating, diagnosing, and monitoring rheumatoid arthritis.
PH12018500045A1 (en) Compositions and methods for treating and diagnosing asthma
MX353143B (en) Biological markers and methods for predicting response to b-cell antagonists.
WO2010036960A3 (en) Methods for treating, diagnosing, and monitoring lupus
WO2013033627A3 (en) Diagnosis and treatment of arthritis using epigenetics
EA201291107A1 (en) METALLIC ENZYME INHIBITING COMPOUNDS
AU2011260390A8 (en) Means and methods for diagnosing pancreatic cancer in a subject
WO2012106718A3 (en) Methods of using gene expression signatures to select a method of treatment, predict prognosis, survival, and/or predict response to treatment
EA201390704A1 (en) METALLIC ENZYME INHIBITING COMPOUNDS
NZ606725A (en) Methods for predicting anti-cancer response
EA201491151A1 (en) METALLIC ENZYME INHIBITING COMPOUNDS
MX355543B (en) Peptidomimetic macrocycles.
TN2013000464A1 (en) Biomarkers for hedgehog inhibitor therapy
MX2010005395A (en) Method of treating arthritis.
WO2011088137A3 (en) Bad pathway gene signature
EP3486657A3 (en) Means and methods for diagnosing pancreatic cancer in a subject
EP2516624A4 (en) CELL LINE 3M
MX337203B (en) Novel jnk inhibitor molecules.
NZ601065A (en) Wnt antagonists and methods of treatment and screening
EP2488187A4 (en) Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same
BR112015013771A2 (en) predictive biomarker of response to treatment of nicotinic acetylcholine alpha 7 receptor activator
IN2012DN00852A (en)
EP3839068A3 (en) Methods for treating, diagnosing, and monitoring lupus
GB201312965D0 (en) Stem cell factor inhibitor
MX358726B (en) PREDICTIVE SURVIVAL BIOMARCATOR IN THE TREATMENT OF CARCINOMA OF RENAL CELLS.