IN2012DN02538A - - Google Patents

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Publication number
IN2012DN02538A
IN2012DN02538A IN2538DEN2012A IN2012DN02538A IN 2012DN02538 A IN2012DN02538 A IN 2012DN02538A IN 2538DEN2012 A IN2538DEN2012 A IN 2538DEN2012A IN 2012DN02538 A IN2012DN02538 A IN 2012DN02538A
Authority
IN
India
Prior art keywords
ions
trapped
characteristic
ejected
target molecule
Prior art date
Application number
Inventor
Lemoine Jerome
salvador Arnaud
Carrier Jean-Philipe
Fortin Tanguy
Dugourd Philippe
Original Assignee
Biomeriux
Univ Claude Bernard Lyon
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomeriux, Univ Claude Bernard Lyon, Centre Nat Rech Scient filed Critical Biomeriux
Publication of IN2012DN02538A publication Critical patent/IN2012DN02538A/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

The present invention relates to a method for detecting at least one target molecule in a sample by mass spectrometry, in which: a) the molecules of the sample are ionized, b) the following steps (i) and (ii) are carried out n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyser, and (ii) the ion thus selected is fragmented in a fragmentation cell, c) at least two different ions obtained in step a) when n is zero, or in step b) when n is other than zero, are trapped in a mass analyser, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule, d) the characteristic ions thus trapped are ejected from the mass analyser, and e) the characteristic ions ejected are detected by means of a detection device. The method of the invention is characterized in that the characteristic ions are ejected simultaneously in step d) and detected simultaneously in step e).
IN2538DEN2012 2009-09-25 2010-09-15 IN2012DN02538A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0956662A FR2950697B1 (en) 2009-09-25 2009-09-25 METHOD FOR DETECTING MOLECULES BY MASS SPECTROMETRY
PCT/FR2010/051919 WO2011036378A1 (en) 2009-09-25 2010-09-15 Method for detecting molecules through mass spectrometry

Publications (1)

Publication Number Publication Date
IN2012DN02538A true IN2012DN02538A (en) 2015-08-28

Family

ID=42105918

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2538DEN2012 IN2012DN02538A (en) 2009-09-25 2010-09-15

Country Status (11)

Country Link
US (1) US9018580B2 (en)
EP (1) EP2481078B1 (en)
JP (1) JP5730878B2 (en)
KR (1) KR20130004561A (en)
CN (1) CN102598204A (en)
BR (1) BR112012006486A2 (en)
FR (1) FR2950697B1 (en)
IN (1) IN2012DN02538A (en)
MX (1) MX2012003626A (en)
RU (1) RU2012113416A (en)
WO (1) WO2011036378A1 (en)

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WO2012143534A2 (en) * 2011-04-21 2012-10-26 Biomerieux Inc. Method for detecting at least one cephalosporin resistance mechanism by means of mass spectrometry
WO2015097504A1 (en) * 2013-12-23 2015-07-02 Dh Technologies Development Pte. Ltd. Mass spectrometer
US11041865B2 (en) * 2015-02-20 2021-06-22 The Johns Hopkins University Biomarkers of myocardial injury
JPWO2016147839A1 (en) * 2015-03-17 2017-12-28 アサヒビール株式会社 Method for quantifying hydrophobin and method for predicting sprayability of foamed malt beverage
JP6473366B2 (en) * 2015-03-31 2019-02-20 シスメックス株式会社 Temperature determination method, target peptide detection method, and temperature determination reagent
CA2986730C (en) * 2015-05-22 2020-04-14 Expression Pathology, Inc. Srm/mrm assay for the cyclin-dependent kinase inhibitor 2a (p16) protein
EP3334508B1 (en) 2015-08-13 2024-12-18 Waters Technologies Corporation Alloy material devices and components
WO2017072893A1 (en) * 2015-10-28 2017-05-04 株式会社島津製作所 Gas chromatograph and sample injection method
US11280766B2 (en) 2016-07-28 2022-03-22 Waters Technologies Corporation Encapsulated pre-analytic workflows for flow-through devices, liquid chromatography and mass spectrometric analysis
EP3373324A1 (en) * 2017-03-10 2018-09-12 Thermo Finnigan LLC Methods and systems for quantitative mass analysis
GB201802917D0 (en) 2018-02-22 2018-04-11 Micromass Ltd Charge detection mass spectrometry
WO2020076765A1 (en) * 2018-10-10 2020-04-16 Purdue Research Foundation Mass spectrometry via frequency tagging
WO2021207494A1 (en) 2020-04-09 2021-10-14 Waters Technologies Corporation Ion detector
US11232936B2 (en) * 2020-05-28 2022-01-25 Thermo Finnigan Llc Absolute quantitation of a target analyte using a mass spectrometer
CN118402037A (en) 2021-12-15 2024-07-26 水技术公司 Inductive detector with integrated amplifier
KR102625713B1 (en) 2021-12-16 2024-01-17 한국전자기술연구원 Smart safety bar system

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US5200613A (en) * 1991-02-28 1993-04-06 Teledyne Mec Mass spectrometry method using supplemental AC voltage signals
CA2240325A1 (en) * 1998-03-27 1998-11-14 Synsorb Biotech, Inc. Methods for screening compound libraries
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US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
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GB0511386D0 (en) * 2005-06-03 2005-07-13 Shimadzu Res Lab Europe Ltd Method for introducing ions into an ion trap and an ion storage apparatus
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Also Published As

Publication number Publication date
CN102598204A (en) 2012-07-18
BR112012006486A2 (en) 2016-11-22
KR20130004561A (en) 2013-01-11
WO2011036378A1 (en) 2011-03-31
MX2012003626A (en) 2012-08-23
US20120205535A1 (en) 2012-08-16
RU2012113416A (en) 2013-10-27
EP2481078B1 (en) 2023-06-21
FR2950697B1 (en) 2011-12-09
US9018580B2 (en) 2015-04-28
EP2481078A1 (en) 2012-08-01
JP2013506124A (en) 2013-02-21
JP5730878B2 (en) 2015-06-10
FR2950697A1 (en) 2011-04-01

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