IN2012DN03176A - - Google Patents
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- Publication number
- IN2012DN03176A IN2012DN03176A IN3176DEN2012A IN2012DN03176A IN 2012DN03176 A IN2012DN03176 A IN 2012DN03176A IN 3176DEN2012 A IN3176DEN2012 A IN 3176DEN2012A IN 2012DN03176 A IN2012DN03176 A IN 2012DN03176A
- Authority
- IN
- India
- Prior art keywords
- crystalline form
- ilaprazole
- preparing
- crystalline
- solvent
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 5
- HRRXCXABAPSOCP-UHFFFAOYSA-N ilaprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC(=CC=C3N=2)N2C=CC=C2)=C1C HRRXCXABAPSOCP-UHFFFAOYSA-N 0.000 abstract 4
- 229950008491 ilaprazole Drugs 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 2
- 239000012046 mixed solvent Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent); a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020090121209A KR101144600B1 (en) | 2009-12-08 | 2009-12-08 | Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B |
| PCT/KR2010/008767 WO2011071314A2 (en) | 2009-12-08 | 2010-12-08 | Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN03176A true IN2012DN03176A (en) | 2015-09-25 |
Family
ID=44146052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3176DEN2012 IN2012DN03176A (en) | 2009-12-08 | 2010-12-08 |
Country Status (7)
| Country | Link |
|---|---|
| KR (1) | KR101144600B1 (en) |
| BR (1) | BR112012012212A2 (en) |
| CO (1) | CO6541539A2 (en) |
| EA (1) | EA019058B1 (en) |
| IN (1) | IN2012DN03176A (en) |
| UA (1) | UA102787C2 (en) |
| WO (1) | WO2011071314A2 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103204843B (en) * | 2012-01-13 | 2014-12-31 | 丽珠医药集团股份有限公司 | Crystalline ilaprazole sodium ethanolate and preparation method thereof |
| CN103204842B (en) * | 2012-01-13 | 2014-10-15 | 丽珠医药集团股份有限公司 | Crystalline Ilaprazole sodium hydrate and preparation method thereof |
| WO2013114232A1 (en) | 2012-02-02 | 2013-08-08 | Lupin Limited | Process for preparation of crystalline form l of ilaprazole |
| CN102746277B (en) * | 2012-06-21 | 2014-05-14 | 丽珠医药集团股份有限公司 | Crystal-form ilaprazole sodium and preparation method thereof |
| CN102746276B (en) * | 2012-06-21 | 2014-07-02 | 丽珠医药集团股份有限公司 | Ilaprazole sodium crystal form and preparation method thereof |
| CN102746275B (en) * | 2012-06-21 | 2014-07-16 | 丽珠医药集团股份有限公司 | Crystallization-type ilaprazole sodium and preparation method thereof |
| CN105461692A (en) * | 2014-09-04 | 2016-04-06 | 江苏奥赛康药业股份有限公司 | Ilaprazole sodium compound and pharmaceutical composition thereof |
| CN107857756B (en) * | 2017-11-06 | 2022-08-30 | 丽珠医药集团股份有限公司 | Ilaprazole magnesium crystal form and preparation method thereof |
| KR102027388B1 (en) | 2017-11-15 | 2019-10-01 | 주식회사 다산제약 | Process for preparing high purity ilaprazole crystalline form B |
| CN111187255B (en) * | 2020-01-13 | 2021-07-20 | 丽珠医药集团股份有限公司 | Preparation method of D-ilaprazole potassium salt and preparation method of D-ilaprazole |
| KR20220065235A (en) | 2020-11-13 | 2022-05-20 | 주식회사 파마코스텍 | Process for the crystalline form of Ilaprazole |
| KR102250509B1 (en) * | 2020-12-09 | 2021-05-11 | 유니셀랩 주식회사 | Novel co-crystal of ilaprazole/xylitol |
| KR20210019469A (en) | 2021-02-02 | 2021-02-22 | 주식회사 파마코스텍 | Crystalline form of Ilaprazole sodium and its new process |
| KR20250156870A (en) | 2024-04-25 | 2025-11-04 | 엠에프씨 주식회사 | Method for producing ilaprazole magnesium salt hydrate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101687848B (en) * | 2006-12-29 | 2013-05-15 | 一洋药品株式会社 | Solid state forms of racemic ilaprazole |
| US20080200515A1 (en) * | 2006-12-29 | 2008-08-21 | Tap Pharmaceutical Products Inc. | Solid state forms of enantiopure ilaprazole |
-
2009
- 2009-12-08 KR KR1020090121209A patent/KR101144600B1/en active Active
-
2010
- 2010-12-08 EA EA201200716A patent/EA019058B1/en not_active IP Right Cessation
- 2010-12-08 BR BR112012012212A patent/BR112012012212A2/en not_active IP Right Cessation
- 2010-12-08 UA UAA201207006A patent/UA102787C2/en unknown
- 2010-12-08 IN IN3176DEN2012 patent/IN2012DN03176A/en unknown
- 2010-12-08 WO PCT/KR2010/008767 patent/WO2011071314A2/en not_active Ceased
-
2012
- 2012-06-08 CO CO12097489A patent/CO6541539A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6541539A2 (en) | 2012-10-16 |
| EA019058B1 (en) | 2013-12-30 |
| UA102787C2 (en) | 2013-08-12 |
| EA201200716A1 (en) | 2012-10-30 |
| WO2011071314A3 (en) | 2011-11-10 |
| WO2011071314A2 (en) | 2011-06-16 |
| BR112012012212A2 (en) | 2015-09-08 |
| KR20110064545A (en) | 2011-06-15 |
| KR101144600B1 (en) | 2012-05-16 |
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