IN2012DN03176A - - Google Patents

Download PDF

Info

Publication number
IN2012DN03176A
IN2012DN03176A IN3176DEN2012A IN2012DN03176A IN 2012DN03176 A IN2012DN03176 A IN 2012DN03176A IN 3176DEN2012 A IN3176DEN2012 A IN 3176DEN2012A IN 2012DN03176 A IN2012DN03176 A IN 2012DN03176A
Authority
IN
India
Prior art keywords
crystalline form
ilaprazole
preparing
crystalline
solvent
Prior art date
Application number
Inventor
Dong Yeon Kim
Jae Soo Shin
Jun Yeoun Lee
Kwi Hyung Cho
Sung Tae Park
Jung Woo Kim
Sang Don Nam
Hee Yun Kim
Original Assignee
Il Yang Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il Yang Pharm Co Ltd filed Critical Il Yang Pharm Co Ltd
Publication of IN2012DN03176A publication Critical patent/IN2012DN03176A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Disclosed are novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms. The novel processes include a process of preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the prepared inorganic salt of ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent); a process of preparing the crystalline form B of high purity by removing impurities from ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of conversion from the crystalline A into the crystalline form B or from the crystalline form B into the crystalline form A.
IN3176DEN2012 2009-12-08 2010-12-08 IN2012DN03176A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (en) 2009-12-08 2009-12-08 Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B
PCT/KR2010/008767 WO2011071314A2 (en) 2009-12-08 2010-12-08 Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms

Publications (1)

Publication Number Publication Date
IN2012DN03176A true IN2012DN03176A (en) 2015-09-25

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3176DEN2012 IN2012DN03176A (en) 2009-12-08 2010-12-08

Country Status (7)

Country Link
KR (1) KR101144600B1 (en)
BR (1) BR112012012212A2 (en)
CO (1) CO6541539A2 (en)
EA (1) EA019058B1 (en)
IN (1) IN2012DN03176A (en)
UA (1) UA102787C2 (en)
WO (1) WO2011071314A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204843B (en) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 Crystalline ilaprazole sodium ethanolate and preparation method thereof
CN103204842B (en) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 Crystalline Ilaprazole sodium hydrate and preparation method thereof
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746275B (en) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 Crystallization-type ilaprazole sodium and preparation method thereof
CN102746277B (en) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 Crystal-form ilaprazole sodium and preparation method thereof
CN102746276B (en) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 Ilaprazole sodium crystal form and preparation method thereof
CN105461692A (en) * 2014-09-04 2016-04-06 江苏奥赛康药业股份有限公司 Ilaprazole sodium compound and pharmaceutical composition thereof
CN115403560B (en) * 2017-11-06 2024-09-03 丽珠医药集团股份有限公司 A kind of ilaprazole magnesium crystal form and preparation method thereof
KR102027388B1 (en) 2017-11-15 2019-10-01 주식회사 다산제약 Process for preparing high purity ilaprazole crystalline form B
CN111187255B (en) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 Preparation method of D-ilaprazole potassium salt and preparation method of D-ilaprazole
KR20220065235A (en) 2020-11-13 2022-05-20 주식회사 파마코스텍 Process for the crystalline form of Ilaprazole
KR102250509B1 (en) * 2020-12-09 2021-05-11 유니셀랩 주식회사 Novel co-crystal of ilaprazole/xylitol
KR20210019469A (en) 2021-02-02 2021-02-22 주식회사 파마코스텍 Crystalline form of Ilaprazole sodium and its new process
KR20250156870A (en) 2024-04-25 2025-11-04 엠에프씨 주식회사 Method for producing ilaprazole magnesium salt hydrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2102192B1 (en) * 2006-12-29 2012-11-14 Il Yang Pharmaceutical Company, Ltd. Solid state forms of racemic ilaprazole
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole

Also Published As

Publication number Publication date
EA201200716A1 (en) 2012-10-30
EA019058B1 (en) 2013-12-30
KR20110064545A (en) 2011-06-15
UA102787C2 (en) 2013-08-12
WO2011071314A3 (en) 2011-11-10
KR101144600B1 (en) 2012-05-16
WO2011071314A2 (en) 2011-06-16
CO6541539A2 (en) 2012-10-16
BR112012012212A2 (en) 2015-09-08

Similar Documents

Publication Publication Date Title
UA102787C2 (en) Process for preparing crystalline forms a and b of ilaprazole and a process of the conversion of crystalline forms
PT2453739E (en) A process for preparing an aqueous suspension of an organic pesticide compound
NZ600119A (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
AU2015221439B2 (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
NZ734451A (en) Preparation, uses and solid forms of obeticholic acid
NZ598277A (en) Process for preparing azabicyclic compounds
NZ705827A (en) Method of synthesizing thyroid hormone analogs and polymorphs thereof
AR076974A1 (en) METHOD FOR SYNTHETIZING PYRFENIDONE
MY167395A (en) Method for producing glufosinate p free acid
PL394857A1 (en) Process for the large scale ammonothermal production of drawn crystals of gallium nitride
MX352470B (en) Malonic acid di-salts and a method for preparing malonyl dihalides.
UA100125C2 (en) Method for isolation and purification of montelukast
PT2462098E (en) Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
ZA200801577B (en) Method for preparing 4ß-Amino-4'-demethyl-4-desoxy-podophyllotoxin
MY146360A (en) Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof
MX2012002818A (en) Novel method for synthesizing ivabradine and the addition salts thereof with a pharmaceutically acceptable acid.
WO2011102640A3 (en) Method for preparing sitagliptin and amine salt intermediates used therein
MX2010009926A (en) New process for the preparatiion of cyclohexanecarboxylic acid dericatives.
MX337997B (en) New method for synthesising ivabradine and its added salts with a pharmaceutically acceptable acid.
UA106595C2 (en) METHOD OF LOSSING
WO2008113661A3 (en) Process for preparing substituted phenylhydrazines
MX2010007923A (en) Crystalline form of abacavir that is essentially free of solvent.
WO2009034582A3 (en) Process for the preparation of amorphous fexofenadine hydrochloride
CL2012001528A1 (en) Process to prepare the crystalline form a of ilaprazole from an inorganic salt of ilaprazole and subsequent neutralization of the salt with an acid in a reaction solvent; and process for preparing the crystalline form b of ilaprazole into the crystalline form a of ilaprazole.
MY183838A (en) Process for the production of a zeolitic material employing elemental precursors