IN2012DN03343A - - Google Patents
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- Publication number
- IN2012DN03343A IN2012DN03343A IN3343DEN2012A IN2012DN03343A IN 2012DN03343 A IN2012DN03343 A IN 2012DN03343A IN 3343DEN2012 A IN3343DEN2012 A IN 3343DEN2012A IN 2012DN03343 A IN2012DN03343 A IN 2012DN03343A
- Authority
- IN
- India
- Prior art keywords
- group
- salt
- present
- benzazepine compound
- perdeuteroalkyl
- Prior art date
Links
- -1 benzazepine compound Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 1
- 102000002852 Vasopressins Human genes 0.000 abstract 1
- 108010004977 Vasopressins Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 1
- 125000005345 deuteroalkyl group Chemical group 0.000 abstract 1
- 229960003726 vasopressin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Studio Devices (AREA)
Abstract
An object of the present invention is to provide a novel benzazepine compound or a salt thereof, which has excellent vasopressin antagonistic activity. The benzazepine compound or a salt thereof of the present invention is represented by Formula (1): wherein R1, R2 and R5 may be the same or different and each represents H or D; and R3 and R4 each represents a C1-6 alkyl group, a C1-6 deuteroalkyl group, or a C1-6 perdeuteroalkyl group.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009245434 | 2009-10-26 | ||
| PCT/JP2010/068807 WO2011052519A1 (en) | 2009-10-26 | 2010-10-25 | Benzazepine compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN03343A true IN2012DN03343A (en) | 2015-10-23 |
Family
ID=43921941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3343DEN2012 IN2012DN03343A (en) | 2009-10-26 | 2010-10-25 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8940727B2 (en) |
| EP (1) | EP2495236A4 (en) |
| JP (1) | JP5717645B2 (en) |
| KR (1) | KR20120092139A (en) |
| CN (3) | CN102753530B (en) |
| AU (1) | AU2010312651A1 (en) |
| BR (1) | BR112012009784A2 (en) |
| CA (1) | CA2778756A1 (en) |
| CO (1) | CO6481003A2 (en) |
| EA (1) | EA022253B1 (en) |
| IL (1) | IL219132A0 (en) |
| IN (1) | IN2012DN03343A (en) |
| MX (1) | MX2012004843A (en) |
| PH (1) | PH12012500762A1 (en) |
| SG (1) | SG10201406839VA (en) |
| WO (1) | WO2011052519A1 (en) |
| ZA (1) | ZA201202640B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3711B1 (en) | 2015-07-13 | 2021-01-31 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| WO2019003433A1 (en) * | 2017-06-30 | 2019-01-03 | 大塚製薬株式会社 | Benzazepine derivative |
| HU231206B1 (en) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepines |
| TW201938171A (en) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | Tricyclic compounds as vasopressin V1a receptor antagonists |
| JP6868089B2 (en) * | 2018-12-28 | 2021-05-12 | 大塚製薬株式会社 | Medicine |
| CN112851583B (en) * | 2021-01-19 | 2023-09-08 | 徐州医科大学 | Novel benzazepine compounds, compositions and uses thereof |
| CN121449554B (en) * | 2026-01-07 | 2026-04-28 | 浙江大学医学院附属邵逸夫医院（浙江省邵逸夫医院） | A drug comprising a small molecule compound having a 2-arcarboxylbenzozazahexamorphic structure and its application. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258510A (en) | 1989-10-20 | 1993-11-02 | Otsuka Pharma Co Ltd | Benzoheterocyclic compounds |
| KR0167349B1 (en) | 1989-10-20 | 1999-02-18 | 오스카 아끼히꼬 | Benzoheterocyclic composition |
| US5753677A (en) | 1989-10-20 | 1998-05-19 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| JP2905909B2 (en) * | 1991-04-19 | 1999-06-14 | 大塚製薬株式会社 | Vasopressin antagonist |
| UA64690C2 (en) * | 1993-07-21 | 2004-03-15 | Yamanouty Farmaceutical Co Ltd | A condensed benzadepine derivative, an intermediate compound for preparing thereof and a pharmaceutical composition |
| CN101273024A (en) * | 2005-07-29 | 2008-09-24 | 康瑟特制药公司 | Novel Benzo[D][1,3]-Dioxole Derivatives |
| CA2654445A1 (en) * | 2006-06-05 | 2007-12-13 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted imidazopyridine compounds with hypnotic effects |
| WO2008049116A2 (en) * | 2006-10-19 | 2008-04-24 | Auspex Pharmaceuticals, Inc. | Substituted indoles |
| TWI459947B (en) * | 2007-06-26 | 2014-11-11 | Otsuka Pharma Co Ltd | Benzodiazepine compounds and pharmaceutical preparations |
| WO2009117144A1 (en) * | 2008-03-20 | 2009-09-24 | Concert Pharmaceuticals, Inc. | Benzazepine compounds |
-
2010
- 2010-10-25 SG SG10201406839VA patent/SG10201406839VA/en unknown
- 2010-10-25 BR BR112012009784A patent/BR112012009784A2/en not_active IP Right Cessation
- 2010-10-25 IN IN3343DEN2012 patent/IN2012DN03343A/en unknown
- 2010-10-25 PH PH1/2012/500762A patent/PH12012500762A1/en unknown
- 2010-10-25 AU AU2010312651A patent/AU2010312651A1/en not_active Abandoned
- 2010-10-25 CN CN201080048410.3A patent/CN102753530B/en not_active Expired - Fee Related
- 2010-10-25 JP JP2011538404A patent/JP5717645B2/en not_active Expired - Fee Related
- 2010-10-25 CN CN201410616974.2A patent/CN104447555A/en active Pending
- 2010-10-25 US US13/504,101 patent/US8940727B2/en not_active Expired - Fee Related
- 2010-10-25 CN CN201510199726.7A patent/CN104829531A/en active Pending
- 2010-10-25 KR KR1020127013513A patent/KR20120092139A/en not_active Withdrawn
- 2010-10-25 CA CA2778756A patent/CA2778756A1/en not_active Abandoned
- 2010-10-25 EA EA201290228A patent/EA022253B1/en not_active IP Right Cessation
- 2010-10-25 EP EP10826651A patent/EP2495236A4/en not_active Withdrawn
- 2010-10-25 WO PCT/JP2010/068807 patent/WO2011052519A1/en not_active Ceased
- 2010-11-25 MX MX2012004843A patent/MX2012004843A/en unknown
-
2012
- 2012-04-12 ZA ZA2012/02640A patent/ZA201202640B/en unknown
- 2012-04-15 IL IL219132A patent/IL219132A0/en unknown
- 2012-05-24 CO CO12086123A patent/CO6481003A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US8940727B2 (en) | 2015-01-27 |
| JP5717645B2 (en) | 2015-05-13 |
| CO6481003A2 (en) | 2012-07-16 |
| CN102753530B (en) | 2015-06-17 |
| CN102753530A (en) | 2012-10-24 |
| JPWO2011052519A1 (en) | 2013-03-21 |
| CN104447555A (en) | 2015-03-25 |
| CN104829531A (en) | 2015-08-12 |
| US20130131045A1 (en) | 2013-05-23 |
| CA2778756A1 (en) | 2011-05-05 |
| ZA201202640B (en) | 2013-06-26 |
| EA022253B1 (en) | 2015-11-30 |
| WO2011052519A1 (en) | 2011-05-05 |
| SG10201406839VA (en) | 2014-12-30 |
| EP2495236A1 (en) | 2012-09-05 |
| EP2495236A4 (en) | 2013-03-27 |
| BR112012009784A2 (en) | 2016-05-17 |
| PH12012500762A1 (en) | 2012-11-26 |
| KR20120092139A (en) | 2012-08-20 |
| IL219132A0 (en) | 2012-06-28 |
| EA201290228A1 (en) | 2012-12-28 |
| AU2010312651A1 (en) | 2012-05-03 |
| MX2012004843A (en) | 2012-05-29 |
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