IN2012DN03403A - - Google Patents

Download PDF

Info

Publication number: IN2012DN03403A
Authority: IN; India
Prior art keywords: simvastatin; producing; huvastatin; materials; related compounds
Prior art date: 2009-10-08

Application number

Other languages

English (en)

Inventor

Yi Tang

Xue Gao

Xinkai Xie

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-08

Filing date

2010-10-08

Publication date

2015-10-23

2010-10-08 Application filed by Univ California filed Critical Univ California

2015-10-23 Publication of IN2012DN03403A publication Critical patent/IN2012DN03403A/en

Links

RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 3
229960002855 simvastatin Drugs 0.000 abstract 3
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000057234 Acyl transferases Human genes 0.000 abstract 1
108700016155 Acyl transferases Proteins 0.000 abstract 1
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
229960004844 lovastatin Drugs 0.000 abstract 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

IN3403DEN2012 2009-10-08 2010-10-08 IN2012DN03403A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24989409P	2009-10-08	2009-10-08
PCT/US2010/052038 WO2011044496A2 (fr)	2009-10-08	2010-10-08	Mutants de lovd possédant des propriétés améliorées pour la synthèse de la simvastatine

Publications (1)

Publication Number	Publication Date
IN2012DN03403A true IN2012DN03403A (fr)	2015-10-23

Family

ID=43857415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN3403DEN2012 IN2012DN03403A (fr)	2009-10-08	2010-10-08

Country Status (7)

Country	Link
US (1)	US8981056B2 (fr)
EP (1)	EP2486129B1 (fr)
CN (1)	CN102695792B (fr)
IL (2)	IL219112B (fr)
IN (1)	IN2012DN03403A (fr)
SG (1)	SG10201504099WA (fr)
WO (1)	WO2011044496A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9499803B2 (en) *	2009-10-08	2016-11-22	The Regents Of The University Of California	Variant LovD polypeptide
CN104342416B (zh) *	2013-07-26	2020-01-17	石药集团中奇制药技术（石家庄）有限公司	含有一个或几个点突变的洛伐他汀酰基转移酶
CN104342417A (zh) *	2013-08-09	2015-02-11	南京朗恩生物科技有限公司	源于土曲霉的活性增强的酰基转移酶突变体
CN103725727B (zh) *	2014-01-06	2016-06-08	苏州汉酶生物技术有限公司	一种辛伐他汀铵盐的制备方法
CN105586325A (zh) *	2016-01-29	2016-05-18	重庆西南合成制药有限公司	一种洛伐他汀酰基转移酶突变体
CN111655855B (zh)	2017-09-14	2025-09-09	生命明疗法股份有限公司	人治疗靶标及其调节剂

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444784A (en)	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4551433A (en)	1981-05-18	1985-11-05	Genentech, Inc.	Microbial hybrid promoters
US4582915A (en)	1983-10-11	1986-04-15	Merck & Co., Inc.	Process for C-methylation of 2-methylbutyrates
US4820850A (en)	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5420024A (en)	1993-05-11	1995-05-30	Merck & Co., Inc.	Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5712146A (en)	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
US6558942B1 (en)	1994-05-06	2003-05-06	The Leland Stanford Junior University	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5849541A (en)	1993-11-02	1998-12-15	Merck & Co., Inc.	DNA encoding triol polyketide synthase
US5393893A (en)	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof
US5763653A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Key intermediates in the manufacture of simvastatin
US5763646A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Process for manufacturing simvastatin from lovastatin or mevinolinic acid
NO991045L (no)	1998-03-05	1999-09-06	Synthon Bv	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
US6391583B1 (en)	1998-12-18	2002-05-21	Wisconsin Alumni Research Foundation	Method of producing antihypercholesterolemic agents
EP1224317B1 (fr)	1999-10-25	2006-03-08	Kosan Biosciences, Inc.	Production de polyc tides
CA2388422A1 (fr)	1999-10-27	2001-05-03	Kosan Biosciences, Inc.	Production heterologue de polycetides
EP1363516B1 (fr)	2001-02-27	2005-08-31	Chong Kun Dang Pharmaceutical Corp.	Procede ameliore de preparation de la simvastatine
AU2002337601A1 (en)	2001-07-25	2003-02-17	International Centre For Genetic Engineering And Biotechnology	Process for the preparation of simvastatin
KR100435142B1 (ko)	2002-01-09	2004-06-09	한미약품 주식회사	개선된 심바스타틴의 제조방법
CN102703539A (zh)	2003-10-21	2012-10-03	维莱尼姆公司	制备新伐他汀及中间体的方法
WO2005066150A1 (fr)	2004-01-02	2005-07-21	Hetero Drugs Limited	Nouveau procede de preparation de simvastatine
BRPI0711889B8 (pt) *	2006-05-24	2021-05-25	Univ California	método para produção de sinvastatina, composição de matéria, método para fabricação de huvastatina, método para fabricação de sinvastatina, e método para fabricação de uma composição de matéria de sinvastatina ou huvastatina
CN101473040A (zh)	2006-06-20	2009-07-01	帝斯曼知识产权资产管理有限公司	生产辛伐他汀的方法
WO2009077523A2 (fr) *	2007-12-18	2009-06-25	Dsm Ip Assets B.V.	Procédé amélioré de production de statines
CN102574896B (zh) *	2009-09-30	2015-04-08	科德克希思公司	变异LovD多肽及其用途

2010
- 2010-10-08 CN CN201080055195.XA patent/CN102695792B/zh active Active
- 2010-10-08 WO PCT/US2010/052038 patent/WO2011044496A2/fr not_active Ceased
- 2010-10-08 IN IN3403DEN2012 patent/IN2012DN03403A/en unknown
- 2010-10-08 SG SG10201504099WA patent/SG10201504099WA/en unknown
- 2010-10-08 US US13/499,356 patent/US8981056B2/en active Active
- 2010-10-08 EP EP10822785.1A patent/EP2486129B1/fr active Active
2012
- 2012-04-05 IL IL219112A patent/IL219112B/en active IP Right Grant
2019
- 2019-05-19 IL IL266709A patent/IL266709B/en active IP Right Grant

Also Published As

Publication number	Publication date
EP2486129A4 (fr)	2013-03-27
WO2011044496A2 (fr)	2011-04-14
WO2011044496A3 (fr)	2011-06-03
IL266709A (en)	2019-07-31
SG10201504099WA (en)	2015-06-29
US20120190038A1 (en)	2012-07-26
EP2486129A2 (fr)	2012-08-15
IL266709B (en)	2020-10-29
US8981056B2 (en)	2015-03-17
IL219112A0 (en)	2012-06-28
CN102695792B (zh)	2015-02-18
IL219112B (en)	2019-06-30
EP2486129B1 (fr)	2016-04-13
CN102695792A (zh)	2012-09-26

Publication	Publication Date	Title
SG176656A1 (en)	2012-01-30	Microorganisms for the production of 1,4-butanediol and related methods
IN2012DN00462A (fr)	2015-06-05
PL2290051T3 (pl)	2017-04-28	Mikroorganizm produkujący O-acetylohomoserynę i sposób wytwarzania O-acetylohomoseryny z użyciem mikroorganizmu
MX2011009539A (es)	2012-02-21	2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso.
MX2011013569A (es)	2012-02-28	Proceso para preparar carbonato de calcio que reacciona en la superficie y su uso.
ZA201100669B (en)	2012-02-29	Methods and compositions for improving the production of products in microorganisms
MX2011013700A (es)	2012-04-30	Cepa talaromyces y composiciones de enzimas.
EP2520288A4 (fr)	2014-01-01	Procédé de production d'une préparation solide et préparation produite par ledit procédé
IN2015DN02634A (fr)	2015-09-18
PL3269819T3 (pl)	2022-02-21	Mikroorganizm wytwarzający o-acetylo-homoserynę i sposób wytwarzania o-acetylo-homoseryny z wykorzystaniem mikroorganizmu
EP2652141A4 (fr)	2014-05-14	Microorganismes et procédés pour la production de 1,4-cyclohexanediméthanol
FI20096050A0 (fi)	2009-10-09	Menetelmä kalsiumkarbonaatin ja ksylaanin saostamiseksi, menetelmällä valmistettu tuote ja sen käyttö
IN2012DN06442A (fr)	2015-10-09
MX341792B (es)	2016-09-02	Biomasa lignocelulósica digeribles y extractos y métodos para producir la misma.
IN2012DN03403A (fr)	2015-10-23
MX2012001306A (es)	2012-02-28	Inhibicion de matastasis de tumor.
MY161868A (en)	2017-05-15	Anti-bv8 antibodies and uses thereof
MX2011012505A (es)	2011-12-14	Piperidinas sustituidas.
MX2011012623A (es)	2011-12-14	Construcciones de casb7439.
NZ598158A (en)	2012-12-21	A process for producing unsaturated cyclic and/or aromatic compounds from 1,8-cineole, the process comprising pyrolysing 1,8-cineole in the presence of gamma-alumina
GB201014794D0 (en)	2010-10-20	Composition of beer and its production method
UA107576C2 (ru)	2015-01-26	Замещенные пиперидины
EP2248768A8 (fr)	2010-12-22	Procédé de production d'eau potable par coagulation-floculation en utilisant un produit minéral contenant des argiles et des carbonates minéraux
EP3456837A3 (fr)	2019-04-24	Compositions de décorine et utilisations associées
PT2451446E (pt)	2014-05-12	Composição para a produção de comprimidos e processo para a sua produção