IN2012DN03403A - - Google Patents

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Info

Publication number: IN2012DN03403A
Authority: IN; India
Prior art keywords: simvastatin; producing; huvastatin; materials; related compounds
Prior art date: 2009-10-08

Application number

Other languages

English (en)

Inventor

Yi Tang

Xue Gao

Xinkai Xie

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-08

Filing date

2010-10-08

Publication date

2015-10-23

2010-10-08 Application filed by Univ California filed Critical Univ California

2015-10-23 Publication of IN2012DN03403A publication Critical patent/IN2012DN03403A/en

Links

RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 3
229960002855 simvastatin Drugs 0.000 abstract 3
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
102000057234 Acyl transferases Human genes 0.000 abstract 1
108700016155 Acyl transferases Proteins 0.000 abstract 1
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
229960004844 lovastatin Drugs 0.000 abstract 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)

IN3403DEN2012 2009-10-08 2010-10-08 IN2012DN03403A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24989409P	2009-10-08	2009-10-08
PCT/US2010/052038 WO2011044496A2 (fr)	2009-10-08	2010-10-08	Mutants de lovd possédant des propriétés améliorées pour la synthèse de la simvastatine

Publications (1)

Publication Number	Publication Date
IN2012DN03403A true IN2012DN03403A (fr)	2015-10-23

Family

ID=43857415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN3403DEN2012 IN2012DN03403A (fr)	2009-10-08	2010-10-08

Country Status (7)

Country	Link
US (1)	US8981056B2 (fr)
EP (1)	EP2486129B1 (fr)
CN (1)	CN102695792B (fr)
IL (2)	IL219112B (fr)
IN (1)	IN2012DN03403A (fr)
SG (1)	SG10201504099WA (fr)
WO (1)	WO2011044496A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9499803B2 (en)	2009-10-08	2016-11-22	The Regents Of The University Of California	Variant LovD polypeptide
CN104342416B (zh) *	2013-07-26	2020-01-17	石药集团中奇制药技术（石家庄）有限公司	含有一个或几个点突变的洛伐他汀酰基转移酶
CN104342417A (zh) *	2013-08-09	2015-02-11	南京朗恩生物科技有限公司	源于土曲霉的活性增强的酰基转移酶突变体
CN103725727B (zh) *	2014-01-06	2016-06-08	苏州汉酶生物技术有限公司	一种辛伐他汀铵盐的制备方法
CN105586325A (zh) *	2016-01-29	2016-05-18	重庆西南合成制药有限公司	一种洛伐他汀酰基转移酶突变体
EP3682022A4 (fr)	2017-09-14	2021-06-09	Lifemine Therapeutics, Inc.	Cibles thérapeutiques humaines et modulateurs associés

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4444784A (en)	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4551433A (en)	1981-05-18	1985-11-05	Genentech, Inc.	Microbial hybrid promoters
US4582915A (en)	1983-10-11	1986-04-15	Merck & Co., Inc.	Process for C-methylation of 2-methylbutyrates
US4820850A (en)	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5420024A (en)	1993-05-11	1995-05-30	Merck & Co., Inc.	Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US6558942B1 (en)	1994-05-06	2003-05-06	The Leland Stanford Junior University	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en)	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
WO1995012661A1 (fr)	1993-11-02	1995-05-11	Merck & Co., Inc.	Adn codant une triol-polycetide-synthase
US5393893A (en)	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof
US5763653A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Key intermediates in the manufacture of simvastatin
US5763646A (en)	1997-03-13	1998-06-09	Ranbaxy Laboratories, Ltd.	Process for manufacturing simvastatin from lovastatin or mevinolinic acid
NO991045L (no)	1998-03-05	1999-09-06	Synthon Bv	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater
US6391583B1 (en) *	1998-12-18	2002-05-21	Wisconsin Alumni Research Foundation	Method of producing antihypercholesterolemic agents
AU1231701A (en)	1999-10-25	2001-05-08	Kosan Biosciences, Inc.	Production of polyketides
AU1105201A (en)	1999-10-27	2001-05-08	Kosan Biosciences, Inc.	Heterologous production of polyketides
JP2004524260A (ja)	2001-02-27	2004-08-12	チョンクンダンファーマスーティカルコーポレイション	シンバスタチンの改善された製造方法
WO2003010324A2 (fr)	2001-07-25	2003-02-06	International Centre For Genetic Engineering And Biotechnology	Methode de preparation de simvastatine
KR100435142B1 (ko)	2002-01-09	2004-06-09	한미약품 주식회사	개선된 심바스타틴의 제조방법
JP4731489B2 (ja)	2003-10-21	2011-07-27	ヴェレニウムコーポレイション	シンバスタチン及び中間体の製造方法
WO2005066150A1 (fr)	2004-01-02	2005-07-21	Hetero Drugs Limited	Nouveau procede de preparation de simvastatine
MX2008014778A (es)	2006-05-24	2009-01-28	Univ California	Metodos y materiales para fabricar simvastatina y compuestos relacionados.
CN101473040A (zh)	2006-06-20	2009-07-01	帝斯曼知识产权资产管理有限公司	生产辛伐他汀的方法
WO2009077523A2 (fr)	2007-12-18	2009-06-25	Dsm Ip Assets B.V.	Procédé amélioré de production de statines
EP2483292B1 (fr)	2009-09-30	2014-11-12	Codexis, Inc.	Polypeptides lovd variants et leurs utilisations

2010
- 2010-10-08 WO PCT/US2010/052038 patent/WO2011044496A2/fr not_active Ceased
- 2010-10-08 IN IN3403DEN2012 patent/IN2012DN03403A/en unknown
- 2010-10-08 SG SG10201504099WA patent/SG10201504099WA/en unknown
- 2010-10-08 US US13/499,356 patent/US8981056B2/en active Active
- 2010-10-08 EP EP10822785.1A patent/EP2486129B1/fr active Active
- 2010-10-08 CN CN201080055195.XA patent/CN102695792B/zh active Active
2012
- 2012-04-05 IL IL219112A patent/IL219112B/en active IP Right Grant
2019
- 2019-05-19 IL IL266709A patent/IL266709B/en active IP Right Grant

Also Published As

Publication number	Publication date
IL219112A0 (en)	2012-06-28
EP2486129A2 (fr)	2012-08-15
IL266709B (en)	2020-10-29
US8981056B2 (en)	2015-03-17
IL266709A (en)	2019-07-31
EP2486129A4 (fr)	2013-03-27
CN102695792B (zh)	2015-02-18
WO2011044496A2 (fr)	2011-04-14
WO2011044496A3 (fr)	2011-06-03
US20120190038A1 (en)	2012-07-26
SG10201504099WA (en)	2015-06-29
EP2486129B1 (fr)	2016-04-13
IL219112B (en)	2019-06-30
CN102695792A (zh)	2012-09-26

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