IN2012DN04381A - - Google Patents
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- Publication number
- IN2012DN04381A IN2012DN04381A IN4381DEN2012A IN2012DN04381A IN 2012DN04381 A IN2012DN04381 A IN 2012DN04381A IN 4381DEN2012 A IN4381DEN2012 A IN 4381DEN2012A IN 2012DN04381 A IN2012DN04381 A IN 2012DN04381A
- Authority
- IN
- India
- Prior art keywords
- acid sequence
- melanoma
- biomarkers
- engrailed
- diagnosis
- Prior art date
Links
- 108700005856 engrailed 2 Proteins 0.000 abstract 3
- 239000000090 biomarker Substances 0.000 abstract 2
- 201000001441 melanoma Diseases 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Described are melanoma specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are uses of the biomarkers in the treatment, diagnosis, monitoring and imaging of melanoma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0921329.9A GB0921329D0 (en) | 2009-12-04 | 2009-12-04 | Biomarker |
| PCT/GB2010/001334 WO2011067549A1 (en) | 2009-12-04 | 2010-07-13 | Melanoma specific biomarker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN04381A true IN2012DN04381A (en) | 2015-08-07 |
Family
ID=41641989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4381DEN2012 IN2012DN04381A (en) | 2009-12-04 | 2010-07-13 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120263654A1 (en) |
| EP (1) | EP2507384A1 (en) |
| JP (1) | JP2013512668A (en) |
| CN (1) | CN102791878A (en) |
| AU (1) | AU2010326433A1 (en) |
| BR (1) | BR112012013041A2 (en) |
| CA (1) | CA2782034A1 (en) |
| GB (1) | GB0921329D0 (en) |
| IL (1) | IL219834A0 (en) |
| IN (1) | IN2012DN04381A (en) |
| MX (1) | MX2012006229A (en) |
| RU (1) | RU2012121096A (en) |
| WO (1) | WO2011067549A1 (en) |
| ZA (1) | ZA201203517B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0913578A2 (en) | 2008-05-14 | 2017-06-06 | Dermtech Int | diagnosis of melanoma and solar lentigo by nucleic acid analysis |
| US20150005184A1 (en) * | 2013-06-28 | 2015-01-01 | Dermtech International | Diagnosis of melanoma by nucleic acid analysis |
| WO2016168174A1 (en) * | 2015-04-13 | 2016-10-20 | The Translational Genomics Research Institute | Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies |
| US11795496B2 (en) * | 2015-06-24 | 2023-10-24 | Oxford BioDynamics PLC | Epigenetic chromosome interactions |
| KR101777085B1 (en) * | 2017-02-23 | 2017-09-11 | 주식회사 성균바이오텍 | Immunogenic segment peptide of EN2 protein, or antibody composition specifically detecting the peptide |
| US11976332B2 (en) | 2018-02-14 | 2024-05-07 | Dermtech, Inc. | Gene classifiers and uses thereof in non-melanoma skin cancers |
| AU2020247911A1 (en) | 2019-03-26 | 2021-11-11 | Dermtech, Llc | Novel gene classifiers and uses thereof in skin cancers |
| RU2766739C1 (en) * | 2021-04-12 | 2022-03-15 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Method for prediction of clinical effectiveness in melanoma |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2469089A1 (en) * | 2003-07-08 | 2005-01-08 | Institut De Recherches Cliniques De Montreal | En-2 gene, disgnostic and therapeutic uses thereof |
| US20070154889A1 (en) * | 2004-06-25 | 2007-07-05 | Veridex, Llc | Methods and reagents for the detection of melanoma |
| US7615349B2 (en) * | 2006-09-07 | 2009-11-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanoma gene signature |
| US7960110B2 (en) * | 2006-11-15 | 2011-06-14 | The Regents Of The University Of California | Detection of chromosomal region copy number changes to diagnose melanoma |
| GB0625321D0 (en) * | 2006-12-19 | 2007-01-24 | Univ Surrey | Cancer biomarker |
| WO2009131733A1 (en) * | 2008-04-21 | 2009-10-29 | The Trustees Of Columbia University In The City Of New York | Gab2 amplification in melanoma |
-
2009
- 2009-12-04 GB GBGB0921329.9A patent/GB0921329D0/en not_active Ceased
-
2010
- 2010-07-13 US US13/513,345 patent/US20120263654A1/en not_active Abandoned
- 2010-07-13 EP EP10742865A patent/EP2507384A1/en not_active Withdrawn
- 2010-07-13 CA CA2782034A patent/CA2782034A1/en not_active Abandoned
- 2010-07-13 CN CN2010800550196A patent/CN102791878A/en active Pending
- 2010-07-13 MX MX2012006229A patent/MX2012006229A/en not_active Application Discontinuation
- 2010-07-13 AU AU2010326433A patent/AU2010326433A1/en not_active Abandoned
- 2010-07-13 BR BR112012013041A patent/BR112012013041A2/en not_active IP Right Cessation
- 2010-07-13 JP JP2012541569A patent/JP2013512668A/en active Pending
- 2010-07-13 WO PCT/GB2010/001334 patent/WO2011067549A1/en not_active Ceased
- 2010-07-13 RU RU2012121096/10A patent/RU2012121096A/en not_active Application Discontinuation
- 2010-07-13 IN IN4381DEN2012 patent/IN2012DN04381A/en unknown
-
2012
- 2012-05-15 ZA ZA2012/03517A patent/ZA201203517B/en unknown
- 2012-05-16 IL IL219834A patent/IL219834A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102791878A (en) | 2012-11-21 |
| MX2012006229A (en) | 2012-06-19 |
| CA2782034A1 (en) | 2011-06-09 |
| WO2011067549A1 (en) | 2011-06-09 |
| AU2010326433A1 (en) | 2012-06-07 |
| GB0921329D0 (en) | 2010-01-20 |
| EP2507384A1 (en) | 2012-10-10 |
| JP2013512668A (en) | 2013-04-18 |
| US20120263654A1 (en) | 2012-10-18 |
| IL219834A0 (en) | 2012-07-31 |
| ZA201203517B (en) | 2013-02-27 |
| BR112012013041A2 (en) | 2016-10-11 |
| RU2012121096A (en) | 2014-01-10 |
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