IN2012DN05054A - - Google Patents

Download PDF

Info

Publication number
IN2012DN05054A
IN2012DN05054A IN5054DEN2012A IN2012DN05054A IN 2012DN05054 A IN2012DN05054 A IN 2012DN05054A IN 5054DEN2012 A IN5054DEN2012 A IN 5054DEN2012A IN 2012DN05054 A IN2012DN05054 A IN 2012DN05054A
Authority
IN
India
Prior art keywords
megakaryocytes
differentiation
platelets
hescs
stromal
Prior art date
Application number
Other languages
English (en)
Inventor
Feng Li
Shi-Jiang Lu
Original Assignee
Stem Call & Regenerative Medicine International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stem Call & Regenerative Medicine International Inc filed Critical Stem Call & Regenerative Medicine International Inc
Publication of IN2012DN05054A publication Critical patent/IN2012DN05054A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2311—Interleukin-11 (IL-11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IN5054DEN2012 2009-12-04 2010-12-03 IN2012DN05054A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26693909P 2009-12-04 2009-12-04
US38416510P 2010-09-17 2010-09-17
PCT/US2010/058990 WO2011069127A1 (fr) 2009-12-04 2010-12-03 Production à grande échelle de plaquettes et de mégacaryocytes fonctionnels provenant de cellules souches embryonnaires humaines, dans des conditions exemptes de stroma

Publications (1)

Publication Number Publication Date
IN2012DN05054A true IN2012DN05054A (fr) 2015-10-09

Family

ID=44115332

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5054DEN2012 IN2012DN05054A (fr) 2009-12-04 2010-12-03

Country Status (10)

Country Link
US (2) US9988603B2 (fr)
EP (1) EP2507359A4 (fr)
JP (4) JP2013512676A (fr)
KR (4) KR20180086301A (fr)
AU (4) AU2010325811A1 (fr)
BR (1) BR112012013497A2 (fr)
CA (2) CA2782013C (fr)
IN (1) IN2012DN05054A (fr)
RU (1) RU2012127810A (fr)
WO (1) WO2011069127A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106434527A (zh) 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
KR20180086301A (ko) 2009-12-04 2018-07-30 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
GB201210857D0 (en) 2012-06-19 2012-08-01 Cambridge Entpr Ltd Transcription factor mediated programming towards megakaryocytes
HK1208054A1 (en) 2012-07-12 2016-02-19 爱姆斯坦生物技术公司 Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
CA2896053A1 (fr) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
US10538738B2 (en) 2014-05-19 2020-01-21 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells
US20180237797A1 (en) * 2015-03-30 2018-08-23 Jeffrey Thomas Loh Methods for in vitro production of platelets and compositions and uses thereof
CN108697641A (zh) 2015-08-18 2018-10-23 安斯泰来再生医药协会 临床制剂
JP7287634B2 (ja) * 2015-10-14 2023-06-06 株式会社メガカリオン 精製血小板の製造方法
JP2021509812A (ja) 2018-01-05 2021-04-08 プレートレット バイオジェネシス， インコーポレイテッド 巨核球を産生するための組成物および方法
EP3813853A4 (fr) 2018-06-29 2022-04-06 Platelet Biogenesis, Inc. Compositions pour l'administration de médicaments et leurs méthodes d'utilisation
US20230190815A1 (en) 2020-05-11 2023-06-22 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles
AU2022264498A1 (en) 2021-04-26 2023-09-28 Strm.Bio Incorporated Compositions and methods related to megakaryocyte-derived extracellular vesicles for fanconi anemia

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128259A (en) 1989-10-27 1992-07-07 Hahnemann University Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation
EP1364197B1 (fr) 2001-01-29 2010-04-14 Ivan N. Rich Essai basé sur l'ATP pour la détermination de la prolifération de cellules hématopoietiques souches et progénitrices
WO2002078449A2 (fr) 2001-04-02 2002-10-10 Advanced Cell Technology, Inc. Procede permettant de faciliter la production de types de cellules et de tissus differencies a partir de cellules pluripotentes et multipotentes embryonnaires et adultes
MXPA04005010A (es) 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
US20040052771A1 (en) 2002-07-12 2004-03-18 Lim Sai Kiang Hemangioblast progenitor cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
CN1286970C (zh) 2003-12-30 2006-11-29 上海伯瑞生物技术发展有限公司 由脐血cd34+细胞体外诱导生成巨核细胞的方法
EP1735429A4 (fr) 2004-03-31 2008-06-11 Newlink Genetics Corp Procedes et compositions destines a l'obtention de cellules souches hematopoietiques derivees de cellules souches embryonnaires et utilisations
AU2005302258B2 (en) * 2004-11-01 2010-10-21 Wisconsin Alumni Research Foundation Platelets from stem cells
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
AU2007215276B2 (en) 2006-02-09 2013-09-19 Maryna E. Gumenyuk Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells
CN101045914A (zh) 2006-03-29 2007-10-03 中国人民解放军军事医学科学院野战输血研究所 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用
CN106434527A (zh) * 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9683232B2 (en) * 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
CA3186451A1 (fr) 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Cellules formant des colonies hemangioblastiques et cellules hemangioblastiques non transplantables
US20110086424A1 (en) 2008-05-06 2011-04-14 Advanced Cell Technology, Inc. Methods for producing enucleated erythroid cells derived from pluripotent stem cells
KR20180086301A (ko) 2009-12-04 2018-07-30 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성

Also Published As

Publication number Publication date
US20120315338A1 (en) 2012-12-13
AU2019203670A1 (en) 2019-06-13
AU2022200188A1 (en) 2022-02-10
EP2507359A4 (fr) 2015-05-13
CA2782013C (fr) 2021-06-08
US20190002829A1 (en) 2019-01-03
US9988603B2 (en) 2018-06-05
CA2782013A1 (fr) 2011-06-09
JP2022064953A (ja) 2022-04-26
KR20210066020A (ko) 2021-06-04
WO2011069127A1 (fr) 2011-06-09
AU2017201995A1 (en) 2017-04-13
EP2507359A1 (fr) 2012-10-10
KR20180086301A (ko) 2018-07-30
AU2017201995B2 (en) 2019-06-06
RU2012127810A (ru) 2014-01-10
KR20120128605A (ko) 2012-11-27
JP2016135138A (ja) 2016-07-28
JP2013512676A (ja) 2013-04-18
CA3115233A1 (fr) 2011-06-09
AU2019203670B2 (en) 2021-10-14
KR20190142424A (ko) 2019-12-26
BR112012013497A2 (pt) 2016-05-31
JP2019122385A (ja) 2019-07-25
AU2010325811A1 (en) 2012-06-21

Similar Documents

Publication Publication Date Title
IN2012DN05054A (fr)
MX358590B (es) Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas.
MX2013002406A (es) Diferenciacion de celulas madre embrionarias humanas.
MX2016005657A (es) Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas.
WO2010149597A3 (fr) Systemes de culture en trois dimensions pour la croissance et la differenciation de cellules souches pluripotentes humaines (hps)
NZ602808A (en) Angiogenesis using placental stem cells
EP2504425A4 (fr) Différenciation de cellules souches embryonnaires humaines et de cellules souches pluripotentes induites
AU336556S (en) Laser system for treatment of the eye
AU337732S (en) Bottle
AU341133S (en) Carburetor main body
TN2012000040A1 (en) High affinity human antibodies to human angiopoietin -2
PH12013501894A1 (en) Human tissue factor antibody and uses thereof
TWD155721S (zh) 瓶子
PH12013500367A1 (en) Differentiation of human embryonic stem cells
TWD146687S (zh) 植入式血液泵浦
MX340253B (es) Recubrimiento de aguja quirúrgica y métodos.
MX2013006595A (es) Tratamiento de lesion de la medula espinal y lesion traumatica del cerebro empleando celulas madre placentarias.
BR112014015342A2 (pt) células-tronco pluripotentes induzidas de células derivadas do tecido do cordão umbilical humano
AU313873S (en) A bath for animals
AU336555S (en) Laser system for treatment of the eye
IN2014KN02364A (fr)
MX336198B (es) Recubrimientos de aguja quirurgicas y metodos.
WO2011068451A3 (fr) Composant céramique utilisé pour la régénération osseuse
GB201201753D0 (en) Therapeutic agents with improved fibrinogen binding
PH12014501383A1 (en) Induced pluripotent stem cells prepared from human kidney-derived cells