IN2013CH01831A - - Google Patents
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- Publication number
- IN2013CH01831A IN2013CH01831A IN1831CH2013A IN2013CH01831A IN 2013CH01831 A IN2013CH01831 A IN 2013CH01831A IN 1831CH2013 A IN1831CH2013 A IN 1831CH2013A IN 2013CH01831 A IN2013CH01831 A IN 2013CH01831A
- Authority
- IN
- India
- Prior art keywords
- regadenoson
- group
- solvent selected
- mixture
- sulphoxide
- Prior art date
Links
- LZPZPHGJDAGEJZ-AKAIJSEGSA-N regadenoson Chemical compound C1=C(C(=O)NC)C=NN1C1=NC(N)=C(N=CN2[C@H]3[C@@H]([C@H](O)[C@@H](CO)O3)O)C2=N1 LZPZPHGJDAGEJZ-AKAIJSEGSA-N 0.000 abstract 5
- 229960003614 regadenoson Drugs 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
A process for the preparation of pure Regadenoson comprising; a. dissolving impure Regadenoson in a mixture of at least one solvent selected form the group consisting of amides, sulphoxide and at least one solvent selected from the group consisting of alcohol; b. treating the solution obtained in step(a) with one anti-solvent selected from the group comprising of nitriles, alcohols or mixture thereof; c. filtering the solid obtained in step (b) to attain pure Regadenoson; d. dissolving Regadenoson in at least one solvent selected from the group consisting of amides, sulphoxide or mixture thereof; e. treating the solution obtained in step (d) with co-solvent to get crystalline form of Regadenoson monohydrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1831CH2013 IN2013CH01831A (en) | 2013-04-25 | 2013-04-25 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1831CH2013 IN2013CH01831A (en) | 2013-04-25 | 2013-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013CH01831A true IN2013CH01831A (en) | 2015-05-29 |
Family
ID=54394912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1831CH2013 IN2013CH01831A (en) | 2013-04-25 | 2013-04-25 |
Country Status (1)
| Country | Link |
|---|---|
| IN (1) | IN2013CH01831A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10442832B2 (en) | 2015-02-06 | 2019-10-15 | Apicore Us Llc | Process of making regadenoson and novel polymorph thereof |
-
2013
- 2013-04-25 IN IN1831CH2013 patent/IN2013CH01831A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10442832B2 (en) | 2015-02-06 | 2019-10-15 | Apicore Us Llc | Process of making regadenoson and novel polymorph thereof |
| US11034714B2 (en) | 2015-02-06 | 2021-06-15 | Apicore Us Llc | Process of making regadenoson and novel polymorphs thereof |
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