IN2013MU03121A - - Google Patents
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- Publication number
- IN2013MU03121A IN2013MU03121A IN3121MU2013A IN2013MU03121A IN 2013MU03121 A IN2013MU03121 A IN 2013MU03121A IN 3121MU2013 A IN3121MU2013 A IN 3121MU2013A IN 2013MU03121 A IN2013MU03121 A IN 2013MU03121A
- Authority
- IN
- India
- Prior art keywords
- relates
- amorphous vortioxetine
- amorphous
- vortioxetine
- salts
- Prior art date
Links
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 abstract 4
- 229960002263 vortioxetine Drugs 0.000 abstract 3
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 2
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 2
- 208000024714 major depressive disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960004030 vortioxetine hydrobromide Drugs 0.000 abstract 1
- VNGRUFUIHGGOOM-UHFFFAOYSA-N vortioxetine hydrobromide Chemical compound Br.CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 VNGRUFUIHGGOOM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Addiction (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2014/000633 WO2015044963A1 (fr) | 2013-09-30 | 2014-09-30 | Vortioxétine amorphe et sels de ladite substance |
| US14/916,075 US10414741B2 (en) | 2013-09-30 | 2014-09-30 | Amorphous vortioxetine and salts thereof |
| IN3121MU2013 IN2013MU03121A (fr) | 2013-09-30 | 2014-09-30 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3121MU2013 IN2013MU03121A (fr) | 2013-09-30 | 2014-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MU03121A true IN2013MU03121A (fr) | 2015-07-17 |
Family
ID=52117938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3121MU2013 IN2013MU03121A (fr) | 2013-09-30 | 2014-09-30 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US10414741B2 (fr) |
| IN (1) | IN2013MU03121A (fr) |
| WO (1) | WO2015044963A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ201531A3 (cs) * | 2015-01-21 | 2016-08-03 | Zentiva, K.S. | Polymerem stabilizované amorfní formy vortioxetinu |
| WO2016125190A2 (fr) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Nouvelles formes cristallines de vortioxétine, prémélanges, et procédés pour la préparation de ceux-ci |
| CN106491604A (zh) * | 2015-09-07 | 2017-03-15 | 常州方楠医药技术有限公司 | 一种无定型沃替西汀或其盐与药用辅料的组合物及其制备方法 |
| WO2017041680A1 (fr) * | 2015-09-07 | 2017-03-16 | 常州方楠医药技术有限公司 | Composition pharmaceutique à base de vortioxétine ou d'un sel de celle-ci, et son procédé de préparation |
| CZ2015633A3 (cs) * | 2015-09-16 | 2017-03-29 | Zentiva, K.S. | Amorfní forma vortioxetin hydrobromidu stabilizovaná cyklodextrinem |
| CN106556663B (zh) * | 2015-09-30 | 2018-05-29 | 成都弘达药业有限公司 | 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法 |
| US20190194154A1 (en) * | 2016-01-20 | 2019-06-27 | Amneal Pharmaceuticals Company Gmbh | Polymorphic Forms Of Vortioxetine Hydrobromide Tert-Butanolate |
| WO2018042168A1 (fr) * | 2016-08-29 | 2018-03-08 | King, Lawrence | Composition pharmaceutique stable de bromhydrate de vortioxétine |
| CN106518807A (zh) * | 2016-09-17 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 乳酸沃替西汀晶型的制备方法 |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| US11020390B2 (en) * | 2017-02-17 | 2021-06-01 | Unichem Laboratories Ltd | Bioequivalent pharmaceutical composition of vortioxetine hydrobromide |
| EP3870292A4 (fr) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | Combinaison d'un inhibiteur de réabsorption spécifique de la sérotonine et d'un agoniste partiel du récepteur de la sérotonine 1a pour réduire la dyskinésie induite par l-dopa |
| WO2021043227A1 (fr) * | 2019-09-04 | 2021-03-11 | 普济生物科技（台州）有限公司 | Granulé enrobé, dispersion solide et préparation contenant du bromhydrate de vortioxétine pour masquage du goût par voie orale |
| TR202001040A2 (tr) * | 2020-01-23 | 2021-07-26 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Vorti̇okseti̇n hi̇drobromi̇di̇n kri̇stali̇n c formu |
| CN112830906B (zh) * | 2020-12-31 | 2022-05-13 | 微研优仿医药科技(江苏)有限公司 | 一种伏硫西汀氢溴酸盐α晶型的制备方法 |
| CN113143886A (zh) * | 2021-05-07 | 2021-07-23 | 苏州康恒研新药物技术有限公司 | 一种氢溴酸伏硫西汀微丸缓释制剂的制备方法 |
| CN115160258B (zh) * | 2022-06-24 | 2023-11-17 | 辰欣药业股份有限公司 | 一种氢溴酸沃替西汀γ晶型的制备方法 |
| WO2025132869A1 (fr) * | 2023-12-21 | 2025-06-26 | H. Lundbeck A/S | Procédé de préparation de compositions pharmaceutiques de vortioxétine présentant de faibles quantités d'impuretés de nitrosamine |
| JP2025109162A (ja) * | 2024-01-11 | 2025-07-24 | Cbc株式会社 | ボルチオキセチン臭化水素酸塩の非晶質体からなる固形物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US119521A (en) * | 1871-10-03 | Improvement in machines for rolling tapering forms | ||
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| KR101627901B1 (ko) * | 2006-06-16 | 2016-06-13 | 하. 룬트벡 아크티에 셀스카브 | 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ht3 및 5-ht1a 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진 |
| TW201033181A (en) | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
| DK2800746T3 (da) | 2012-01-03 | 2019-05-20 | H Lundbeck As | Fremgangsmåde til fremstilling af 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin |
| CN104797566B (zh) * | 2012-09-19 | 2017-07-07 | 桑多斯股份公司 | 沃替西汀氢溴酸盐的新结晶形式 |
| WO2014177491A1 (fr) | 2013-04-29 | 2014-11-06 | Lek Pharmaceuticals D.D. | Nouvelle forme solide de bromhydrate de 1-(2-((2,4-diméthylphényl)thio)phényl)pipérazine |
| EP3209297A1 (fr) * | 2014-10-24 | 2017-08-30 | Hexal Aktiengesellschaft | Bromhydrate de vortioxétine amorphe |
-
2014
- 2014-09-30 IN IN3121MU2013 patent/IN2013MU03121A/en unknown
- 2014-09-30 WO PCT/IN2014/000633 patent/WO2015044963A1/fr not_active Ceased
- 2014-09-30 US US14/916,075 patent/US10414741B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015044963A1 (fr) | 2015-04-02 |
| US20160214949A1 (en) | 2016-07-28 |
| US10414741B2 (en) | 2019-09-17 |
| WO2015044963A9 (fr) | 2015-05-07 |
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