IN2013MU03696A - - Google Patents

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Publication number
IN2013MU03696A
IN2013MU03696A IN3696MU2013A IN2013MU03696A IN 2013MU03696 A IN2013MU03696 A IN 2013MU03696A IN 3696MU2013 A IN3696MU2013 A IN 3696MU2013A IN 2013MU03696 A IN2013MU03696 A IN 2013MU03696A
Authority
IN
India
Prior art keywords
iii
diethyl
acetamido
malonate
fingolimod hydrochloride
Prior art date
Application number
Inventor
Mukund Keshav Gurjar
Narendra Kumar Tripathy
Kaliaperumal Neelakandan
Prasad Pandurang Panchabhai
Nandala Srinivas
Prabhakaran Balasubramanian
Sandip Bajaba Buchude
Balaji Ram Mugale
Pravin Prabhakar Ahirrao
Samit Satish Mehta
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Priority to US15/035,306 priority Critical patent/US9643914B2/en
Priority to IN3696MU2013 priority patent/IN2013MU03696A/en
Priority to ES14853182T priority patent/ES2729404T3/en
Priority to CA2930089A priority patent/CA2930089C/en
Priority to PCT/IN2014/000720 priority patent/WO2015092809A2/en
Priority to EP14853182.5A priority patent/EP3074374B1/en
Publication of IN2013MU03696A publication Critical patent/IN2013MU03696A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for preparation of diethyl 2-acetamido-2-(4-octyI phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4-octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (la) is having associated impurities below the regulatory limits.
IN3696MU2013 2013-11-25 2014-11-14 IN2013MU03696A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US15/035,306 US9643914B2 (en) 2013-11-25 2014-11-14 Fingolimod hydrochloride process
IN3696MU2013 IN2013MU03696A (en) 2013-11-25 2014-11-14
ES14853182T ES2729404T3 (en) 2013-11-25 2014-11-14 Fingolimod hydrochloride process
CA2930089A CA2930089C (en) 2013-11-25 2014-11-14 Fingolimod hydrochloride process
PCT/IN2014/000720 WO2015092809A2 (en) 2013-11-25 2014-11-14 Fingolimod hydrochloride process
EP14853182.5A EP3074374B1 (en) 2013-11-25 2014-11-14 Fingolimod hydrochloride process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3696MU2013 IN2013MU03696A (en) 2013-11-25 2014-11-14

Publications (1)

Publication Number Publication Date
IN2013MU03696A true IN2013MU03696A (en) 2015-07-31

Family

ID=52823744

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3696MU2013 IN2013MU03696A (en) 2013-11-25 2014-11-14

Country Status (6)

Country Link
US (1) US9643914B2 (en)
EP (1) EP3074374B1 (en)
CA (1) CA2930089C (en)
ES (1) ES2729404T3 (en)
IN (1) IN2013MU03696A (en)
WO (1) WO2015092809A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020165672A1 (en) 2019-02-15 2020-08-20 Shivalik Rasayan Limited Process for preparation of highly pure fingolimod hydrochloride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69321823T2 (en) 1992-10-21 1999-06-02 Taito Co., Ltd., Tokio/Tokyo 2-AMINO-1, 3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSIUM
DK1129066T3 (en) 1998-11-11 2005-03-29 Novartis Ag Preparation of 2-amino-2- [2- (C2-20 alkylphenyl) ethyl] propane-1,3-diols
US6423871B1 (en) * 1999-02-26 2002-07-23 University Of South Florida Efficient synthesis of secondary amines by selective alkylation of primary amines
WO2012070059A1 (en) * 2010-11-25 2012-05-31 Shilpa Medicare Limited Fingolimod polymorphs and their processes
US9216943B2 (en) 2011-04-29 2015-12-22 Dr. Reddy's Laboratories Ltd. Preparation of fingolimod and its salts
WO2013111162A2 (en) 2012-01-25 2013-08-01 Glenmark Generics Limited Process for preparation of fingolimod

Also Published As

Publication number Publication date
EP3074374A2 (en) 2016-10-05
ES2729404T3 (en) 2019-11-04
CA2930089A1 (en) 2015-06-25
WO2015092809A3 (en) 2015-08-13
US20160289166A1 (en) 2016-10-06
WO2015092809A2 (en) 2015-06-25
CA2930089C (en) 2021-08-03
EP3074374B1 (en) 2019-03-13
US9643914B2 (en) 2017-05-09

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