IN2014CH00247A - - Google Patents

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Publication number
IN2014CH00247A
IN2014CH00247A IN247CH2014A IN2014CH00247A IN 2014CH00247 A IN2014CH00247 A IN 2014CH00247A IN 247CH2014 A IN247CH2014 A IN 247CH2014A IN 2014CH00247 A IN2014CH00247 A IN 2014CH00247A
Authority
IN
India
Prior art keywords
novel
dolutegravir
preparation
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
Inventor
Chava Satyanarayana
Ramanjaneyulu Gorantla Seeta
Lakshmi Narasimha Rao Dammalapati Venkata
Bushan Kotala Mani
Aduri Ravindra
Original Assignee
Laurus Labs Private Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Ltd filed Critical Laurus Labs Private Ltd
Priority to EP15740288.4A priority Critical patent/EP3096763B1/en
Priority to US15/113,080 priority patent/US9856271B2/en
Priority to ES15740288T priority patent/ES2770050T3/en
Priority to IN247CH2014 priority patent/IN2014CH00247A/en
Priority to PCT/IB2015/000048 priority patent/WO2015110897A2/en
Priority to PCT/IN2015/000040 priority patent/WO2015111080A2/en
Publication of IN2014CH00247A publication Critical patent/IN2014CH00247A/en
Priority to US15/809,151 priority patent/US10301321B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.
IN247CH2014 2014-01-21 2015-01-20 IN2014CH00247A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP15740288.4A EP3096763B1 (en) 2014-01-21 2015-01-20 Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
US15/113,080 US9856271B2 (en) 2014-01-21 2015-01-20 Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
ES15740288T ES2770050T3 (en) 2014-01-21 2015-01-20 New procedure for the preparation of dolutegravir and its pharmaceutically acceptable salts
IN247CH2014 IN2014CH00247A (en) 2014-01-21 2015-01-20
PCT/IB2015/000048 WO2015110897A2 (en) 2014-01-21 2015-01-20 Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
PCT/IN2015/000040 WO2015111080A2 (en) 2014-01-21 2015-01-21 Novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
US15/809,151 US10301321B2 (en) 2014-01-21 2017-11-10 Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN247CH2014 IN2014CH00247A (en) 2014-01-21 2015-01-20

Publications (1)

Publication Number Publication Date
IN2014CH00247A true IN2014CH00247A (en) 2015-08-14

Family

ID=53682060

Family Applications (1)

Application Number Title Priority Date Filing Date
IN247CH2014 IN2014CH00247A (en) 2014-01-21 2015-01-20

Country Status (5)

Country Link
US (2) US9856271B2 (en)
EP (1) EP3096763B1 (en)
ES (1) ES2770050T3 (en)
IN (1) IN2014CH00247A (en)
WO (2) WO2015110897A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10519168B2 (en) 2014-06-20 2019-12-31 Gilead Sciences, Inc. Synthesis of polycyclic-carbamoylpyridone compounds
US11634431B2 (en) 2018-07-12 2023-04-25 Laurus Labs Limited Process for purification of protected polycyclic carbamoylpyridone derivatives

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2893843C (en) 2012-12-21 2018-09-04 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (en) 2013-07-12 2018-07-21
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
NO2717902T3 (en) 2014-06-20 2018-06-23
CZ201599A3 (en) * 2015-02-13 2016-08-24 Zentiva, K.S. Solid forms of dolutegravir salts and process for preparing thereof
US10696636B2 (en) 2015-12-21 2020-06-30 Lupin Limited Process for the preparation of HIV integrase inhibitors
CN105699509B (en) * 2016-01-23 2018-08-31 河北科技大学 A kind of method for separating and detecting of 3- amino butanols enantiomter
CN106565747A (en) * 2016-11-10 2017-04-19 顾世海 Novel method for preparing dolutegravir
US20210040116A1 (en) 2017-09-07 2021-02-11 Cipla Limited New Polymorphs of Dolutegravir Sodium
AU2018344739B2 (en) 2017-10-06 2023-04-13 Shionogi & Co., Ltd. Stereoselective process for preparing substituted polycyclic pyridone derivatives
CN107935881B (en) * 2017-12-11 2020-06-26 浙江朗华制药有限公司 Preparation method of N- [ (2, 4-difluorophenyl) methyl ] -4-methoxy-3-oxobutanamide
WO2020081143A1 (en) * 2018-10-19 2020-04-23 Virginia Commonwealth University Novel pyrrole and pyridone derivatives and uses thereof
US11248005B2 (en) 2019-07-08 2022-02-15 Lupin Limited Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor
CN110294705A (en) * 2019-07-25 2019-10-01 浙江沙星科技有限公司 A kind of synthetic method of Du Lutewei key intermediate
CN111620891B (en) * 2020-05-27 2023-07-14 上海启讯医药科技有限公司 Polyteplavir key intermediate solvate polymorph and preparation method and application thereof
EP4249077A4 (en) 2020-11-17 2025-02-12 Shionogi & Co., Ltd NEW ACRIDINIUM SALT AND ITS PRODUCTION PROCESS
CN116496297B (en) * 2023-03-24 2025-03-11 天津大学 A kind of dolutegravir oxalic acid cocrystal and its preparation method and application

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1874117E (en) * 2005-04-28 2013-10-17 Shionogi & Co Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
WO2010011819A1 (en) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
SI2320908T1 (en) 2008-07-25 2014-05-30 Viiv Healthcare Company Dolutegravir Prodrugs
KR101733625B1 (en) * 2008-12-11 2017-05-10 시오노기세야쿠 가부시키가이샤 Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
KR101678563B1 (en) 2008-12-11 2016-11-22 비이브 헬쓰케어 컴퍼니 Processes and intermediates for carbamoylpyridone hiv integrase inhibitors
TWI582097B (en) 2010-03-23 2017-05-11 Ｖｉｉｖ醫療保健公司 Process for preparing carbamoylpyridone derivatives and intermediates
PT2602260T (en) * 2010-08-05 2016-12-27 Shionogi & Co Process for preparing compound having hiv integrase inhibitory activity
EP3016935B1 (en) 2013-07-04 2018-09-05 Hetero Research Foundation Process for the preparation of intermediate of dolutegravir
ZA201503540B (en) 2014-05-20 2016-10-26 Cipla Ltd Process for preparing polycyclic carbamoyl pyridone derivatives
TWI677489B (en) 2014-06-20 2019-11-21 美商基利科學股份有限公司 Synthesis of polycyclic-carbamoylpyridone compounds
WO2016092527A1 (en) 2014-12-12 2016-06-16 Sun Pharmaceutical Industries Limited A process for the preparation of dolutegravir

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10519168B2 (en) 2014-06-20 2019-12-31 Gilead Sciences, Inc. Synthesis of polycyclic-carbamoylpyridone compounds
US10975096B2 (en) 2014-06-20 2021-04-13 Gilead Sciences, Inc. Synthesis of polycyclic-carbamoylpyridone compounds
US11634431B2 (en) 2018-07-12 2023-04-25 Laurus Labs Limited Process for purification of protected polycyclic carbamoylpyridone derivatives

Also Published As

Publication number Publication date
WO2015110897A2 (en) 2015-07-30
US20160333026A1 (en) 2016-11-17
ES2770050T3 (en) 2020-06-30
EP3096763A2 (en) 2016-11-30
WO2015110897A3 (en) 2015-12-03
US20180155364A1 (en) 2018-06-07
EP3096763A4 (en) 2017-06-28
WO2015111080A2 (en) 2015-07-30
EP3096763B1 (en) 2019-12-25
US9856271B2 (en) 2018-01-02
US10301321B2 (en) 2019-05-28

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