IN2014CH00518A - - Google Patents

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Info

Publication number: IN2014CH00518A
Authority: IN; India
Prior art keywords: formula; compound; bzo; deoxy; fluoro
Prior art date: 2014-02-04

Application number

Other languages

English (en)

Inventor

Thirumalai Rajan Srinivasan

Kishore Kumar Muppa

Srinivas Rao Nimmala

Original Assignee

Msn Lab Private Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-02-04

Filing date

2015-02-04

Publication date

2015-08-07

2015-02-04 Application filed by Msn Lab Private Ltd filed Critical Msn Lab Private Ltd

2015-02-04 Priority to PCT/IN2015/000068 priority Critical patent/WO2015118558A2/en

2015-02-04 Priority to IN518CH2014 priority patent/IN2014CH00518A/en

2015-08-07 Publication of IN2014CH00518A publication Critical patent/IN2014CH00518A/en

Links

-1 Clofarabine compound Chemical class 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 5
239000002904 solvent Substances 0.000 abstract 5
229960000928 clofarabine Drugs 0.000 abstract 4
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 1
150000008041 alkali metal carbonates Chemical class 0.000 abstract 1
150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
238000005576 amination reaction Methods 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 abstract 1
238000007360 debenzoylation reaction Methods 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Hematology (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)

IN518CH2014 2014-02-04 2015-02-04 IN2014CH00518A (pl)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
PCT/IN2015/000068 WO2015118558A2 (en)	2014-02-04	2015-02-04	Process for the preparation of clofarabine
IN518CH2014 IN2014CH00518A (pl)	2014-02-04	2015-02-04

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN518CH2014 IN2014CH00518A (pl)	2014-02-04	2015-02-04

Publications (1)

Publication Number	Publication Date
IN2014CH00518A true IN2014CH00518A (pl)	2015-08-07

Family

ID=53778571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN518CH2014 IN2014CH00518A (pl)	2014-02-04	2015-02-04

Country Status (2)

Country	Link
IN (1)	IN2014CH00518A (pl)
WO (1)	WO2015118558A2 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN105601688A (zh) *	2015-12-23	2016-05-25	国药一心制药有限公司	一种氯法拉滨中间体及氯法拉滨的制备方法
CN106397518B (zh) *	2016-10-18	2019-05-17	武汉百科药物开发有限公司	一种氯法拉滨的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4555536B2 (ja) *	2000-02-18	2010-10-06	サザン・リサーチ・インスティテュート	２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
ES2306783T3 (es) *	2001-08-02	2008-11-16	Ilex Oncology, Inc.	Procedimiento para preparar nucleosidos purinicos.
CN101555267A (zh) *	2008-04-09	2009-10-14	杭州容立医药科技有限公司	一种核苷酸类似物克罗拉滨的合成方法
CN101265284B (zh) *	2008-05-07	2011-04-27	深圳万乐药业有限公司	氯法拉滨的合成方法

2015
- 2015-02-04 WO PCT/IN2015/000068 patent/WO2015118558A2/en not_active Ceased
- 2015-02-04 IN IN518CH2014 patent/IN2014CH00518A/en unknown

Also Published As

Publication number	Publication date
WO2015118558A2 (en)	2015-08-13
WO2015118558A3 (en)	2015-11-05

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