IN2014DN05803A - - Google Patents

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Publication number
IN2014DN05803A
IN2014DN05803A IN5803DEN2014A IN2014DN05803A IN 2014DN05803 A IN2014DN05803 A IN 2014DN05803A IN 5803DEN2014 A IN5803DEN2014 A IN 5803DEN2014A IN 2014DN05803 A IN2014DN05803 A IN 2014DN05803A
Authority
IN
India
Prior art keywords
subject
inhibitor
gene
cancer
deletion
Prior art date
Application number
Other languages
English (en)
Inventor
Florian L Muller
Sananikone Eliot Fletcher
Simona Colla
Elisa Aquilanti
Ronald Depinho
Original Assignee
Univ Texas
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Dana Farber Cancer Inst Inc filed Critical Univ Texas
Publication of IN2014DN05803A publication Critical patent/IN2014DN05803A/en

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
IN5803DEN2014 2011-12-14 2012-12-14 IN2014DN05803A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161570366P 2011-12-14 2011-12-14
US201261652738P 2012-05-29 2012-05-29
PCT/US2012/069767 WO2013090732A2 (fr) 2011-12-14 2012-12-14 Biomarqueurs d'inactivation de gène collatérale et cibles pour une thérapie anticancéreuse

Publications (1)

Publication Number Publication Date
IN2014DN05803A true IN2014DN05803A (fr) 2015-05-15

Family

ID=48613367

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5803DEN2014 IN2014DN05803A (fr) 2011-12-14 2012-12-14

Country Status (11)

Country Link
US (1) US9452182B2 (fr)
EP (2) EP2790738B1 (fr)
JP (2) JP6820653B2 (fr)
KR (2) KR102144452B1 (fr)
CN (3) CN104144707B (fr)
DK (1) DK2790738T3 (fr)
ES (1) ES2746058T3 (fr)
HR (1) HRP20191607T1 (fr)
HU (1) HUE045359T2 (fr)
IN (1) IN2014DN05803A (fr)
WO (1) WO2013090732A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015204452A1 (en) 2014-01-13 2016-08-11 Berg Llc Enolase 1 (Eno1) compositions and uses thereof
CN104894229A (zh) * 2014-03-04 2015-09-09 中南大学 己糖激酶2作为鼻咽癌放疗预后预测的生物标志物
EP3240566B1 (fr) * 2014-12-31 2020-07-22 Development Center for Biotechnology Anticorps humanisés spécifiques de l'alpha-énolase et méthodes d'utilisation en thérapie anticancéreuse
WO2016145113A1 (fr) 2015-03-09 2016-09-15 Board Of Regents, The University Of Texas System Inhibiteurs des énolases et méthodes de traitement les utilisant
EP3368687B1 (fr) * 2015-10-27 2021-09-29 The Broad Institute, Inc. Compositions et procédés de ciblage de variations de séquences spécifiques du cancer
CA2937896A1 (fr) * 2016-08-02 2018-02-02 Universite De Montreal Utilisation de mubritinib pour le traitement d'un mauvais diagnostic de leucemie myeloide aigue
CN107217054B (zh) * 2017-04-25 2020-08-14 中山大学肿瘤防治中心 G6pd基因及其表达产物在治疗结直肠癌中的应用
CN107460250B (zh) * 2017-09-28 2020-07-28 郑州大学第一附属医院 基于kif14、kif15和kif20a基因的透明细胞肾癌诊断试剂盒及其使用方法
IL284284B2 (en) * 2019-02-26 2026-03-01 Novocure Gmbh Frequency determination for tumor-treating field therapy is based on the electrical characteristic of targeted cancer cells.
PH12021552110A1 (en) * 2019-03-29 2022-06-06 Univ Texas Compounds with anti-tumor activity against cancer cells bearing her2 exon 21 insertions
EP3976195A4 (fr) * 2019-05-28 2023-10-18 The Regents Of The University Of California Méthodes de traitement de cancers neuroendocriniens à petites cellules et de cancers associés
EP4093513A4 (fr) * 2020-01-24 2024-05-08 Dana-Farber Cancer Institute, Inc. Utilisations de biomarqueurs pour améliorer une immunothérapie
CN113567675B (zh) * 2020-04-28 2023-09-22 苏州浚惠生物科技有限公司 用于肿瘤的己糖激酶2抑制剂液体活检伴随诊断和试剂盒
EP4225908A1 (fr) * 2020-10-06 2023-08-16 European Molecular Biology Laboratory Procédé de criblage pour l'identification de nouveaux composés thérapeutiques
US20250019708A1 (en) * 2021-11-19 2025-01-16 Institut Curie Methods for the treatment of hrd cancer and brca-associated cancer
WO2023239958A1 (fr) * 2022-06-10 2023-12-14 The Children's Hospital Of Philadelphia Isoforme épissée en variante dans le cancer et ses méthodes d'utilisation
CN114751961B (zh) * 2022-06-14 2022-09-20 中山大学孙逸仙纪念医院 circ0005199-173aa蛋白及其在制备食管癌诊断产品中的应用
CN115074445B (zh) * 2022-08-09 2023-08-08 河北医科大学第二医院 Eno3在肾癌诊断及治疗中的应用
CN115825308B (zh) * 2022-11-30 2023-06-09 江西省肿瘤医院(江西省第二人民医院、江西省癌症中心) 鼻咽癌相关尿液标志物在制备用于鼻咽癌诊断/预后的产品中的应用
CN116286828B (zh) * 2023-05-12 2023-08-18 中国人民解放军军事科学院军事医学研究院 一种寡聚核酸siRNA及其在制备用于预防和治疗肝癌的药物中的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279721A (en) 1993-04-22 1994-01-18 Peter Schmid Apparatus and method for an automated electrophoresis system
WO1998041648A2 (fr) * 1997-03-20 1998-09-24 Variagenics, Inc. Genes cibles pour medicaments specifiques d'alleles
US6046002A (en) 1998-01-05 2000-04-04 The Board Of Trustees Of The Leland Stanford Junior University Highly parallel and sensitive method for identifying drugs and drug targets
US6200754B1 (en) * 1998-03-19 2001-03-13 Variagenics, Inc. Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
US20030013656A1 (en) 2001-05-03 2003-01-16 Bing Wang Pyruvate derivatives
WO2003082187A2 (fr) * 2002-03-26 2003-10-09 Indiana University Purification et clonage de nmn adenylyltranserase et son utilisation therapeutique
ATE432097T1 (de) * 2004-08-30 2009-06-15 Interstitial Therapeutics Medizinischer stent mit atp-synthesehemmern
JP5109131B2 (ja) * 2005-02-10 2012-12-26 オンコセラピー・サイエンス株式会社 膀胱癌を診断する方法
WO2007072219A2 (fr) * 2005-09-21 2007-06-28 Aurelium Biopharma Inc. Methodes diagnostiques et therapeutiques utilisant alpha-enolase pour detecter le cancer et la resistance a un medicament chimiotherapeutique
CA2645095A1 (fr) 2006-03-08 2007-09-13 University Of Maryland, Baltimore Inhibition de protrusion de microtubule dans des cellules cancereuses
US20100189648A1 (en) * 2006-11-02 2010-07-29 Lan Huang Inhibitors for disrupting the interaction of ubiquitination related enzymes and uses thereof
TWI615403B (zh) 2007-02-21 2018-02-21 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
US8178317B2 (en) * 2007-05-01 2012-05-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for identifying transforming and tumor suppressor genes
CN102225201A (zh) * 2010-05-11 2011-10-26 中国医学科学院基础医学研究所 糖酵解抑制剂的新用途

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