IN2014DN06768A - - Google Patents
Info
- Publication number
- IN2014DN06768A IN2014DN06768A IN6768DEN2014A IN2014DN06768A IN 2014DN06768 A IN2014DN06768 A IN 2014DN06768A IN 6768DEN2014 A IN6768DEN2014 A IN 6768DEN2014A IN 2014DN06768 A IN2014DN06768 A IN 2014DN06768A
- Authority
- IN
- India
- Prior art keywords
- protected
- protected oligonucleotide
- elongation
- discovered
- conducted
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000000622 liquid--liquid extraction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 150000008300 phosphoramidites Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012033429 | 2012-02-17 | ||
| JP2012254718 | 2012-11-20 | ||
| PCT/JP2013/053769 WO2013122236A1 (ja) | 2012-02-17 | 2013-02-15 | 塩基部保護オリゴヌクレオチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014DN06768A true IN2014DN06768A (de) | 2015-05-22 |
Family
ID=48984345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN6768DEN2014 IN2014DN06768A (de) | 2012-02-17 | 2013-02-15 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3296306B1 (de) |
| JP (1) | JP6237237B2 (de) |
| CN (2) | CN106977567B (de) |
| IN (1) | IN2014DN06768A (de) |
| WO (1) | WO2013122236A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029528B2 (en) | 2011-05-17 | 2015-05-12 | Ajinomoto Co., Inc. | Solution-based method of making oligonucleotides via phosphoramidite coupling |
| WO2013179412A1 (ja) * | 2012-05-30 | 2013-12-05 | 北海道システム・サイエンス株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
| US10214555B2 (en) | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| JP6673211B2 (ja) | 2014-10-14 | 2020-03-25 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| CN108350018A (zh) * | 2015-11-17 | 2018-07-31 | 日产化学工业株式会社 | 寡核苷酸的制造方法 |
| EP3398955B1 (de) * | 2015-12-16 | 2026-06-03 | Ajinomoto Co., Inc. | Oligonukleotidherstellungsverfahren und nukleosid, nukleotid oder oligonukleotid |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| CN107556355B (zh) * | 2016-06-30 | 2021-10-22 | 上海兆维科技发展有限公司 | 一种核苷双亚磷酰胺及其制备方法 |
| JP7306263B2 (ja) * | 2017-05-02 | 2023-07-11 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| JP7140111B2 (ja) * | 2017-05-16 | 2022-09-21 | 日産化学株式会社 | オリゴヌクレオチドの製造方法 |
| JP2021516673A (ja) * | 2018-03-14 | 2021-07-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｌｎａ−ジカルボン酸誘導体およびその調製のための方法 |
| US11560401B2 (en) | 2018-05-10 | 2023-01-24 | Nippon Shinyaku Co., Ltd. | Method for preparing oligonucleic acid compound |
| JP7583712B2 (ja) * | 2018-05-30 | 2024-11-14 | ノバルティス アーゲー | 脂質修飾された核酸化合物および方法 |
| CN113423715A (zh) | 2019-02-15 | 2021-09-21 | 味之素株式会社 | 寡核苷酸的制造方法 |
| EP3950698A4 (de) * | 2019-03-28 | 2023-01-25 | Ajinomoto Co., Inc. | Verfahren zur herstellung eines oligonukleotids mit phosphorothioatstelle |
| CN114206897B (zh) | 2019-05-08 | 2024-09-20 | 比奥根Ma公司 | 寡核苷酸的汇聚液相合成 |
| JPWO2021045141A1 (de) * | 2019-09-04 | 2021-03-11 | ||
| EP4059943A4 (de) | 2019-11-13 | 2024-01-31 | Nippon Shinyaku Co., Ltd. | Verfahren zur herstellung einer oligonukleidsäureverbindung |
| EP4059944A4 (de) | 2019-11-13 | 2024-04-10 | Nippon Shinyaku Co., Ltd. | Verfahren zur herstellung einer oligonukleidsäureverbindung |
| CN111039977B (zh) * | 2019-12-31 | 2022-11-08 | 广州同隽医药科技有限公司 | 一种亚磷酰化试剂及其在寡核苷酸合成中的应用 |
| CA3198433A1 (en) * | 2020-11-11 | 2022-05-19 | Wuming YAN | Oligonucleotides, reagents and preparation thereof |
| CN117279926A (zh) | 2021-04-28 | 2023-12-22 | 日本新药株式会社 | 低聚核酸化合物的制造方法 |
| KR20240129006A (ko) | 2021-12-27 | 2024-08-27 | 니뽄 신야쿠 가부시키가이샤 | 올리고 핵산 화합물의 제조 방법 |
| EP4678626A1 (de) | 2023-03-06 | 2026-01-14 | Spera Pharma, Inc. | Langkettiges alkenyloxysubstituiertes benzoylderivat und oligonukleotidsyntheseverfahren damit |
| CN121464145A (zh) * | 2023-05-01 | 2026-02-03 | 株式会社纳蒂亚斯 | 寡核苷酸合成用的高脂溶性核苷酸砌块及使用其的寡核苷酸的合成 |
| EP4695265A1 (de) | 2023-10-16 | 2026-02-18 | Bachem Holding AG | Verfahren und zusammensetzung zur synthese von oligonukleotiden |
| CN122580428A (zh) * | 2024-01-18 | 2026-08-14 | 北京安龙生物医药有限公司 | 靶向第13型17β-羟基类固醇脱氢酶的寡核苷酸及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61112093A (ja) * | 1984-11-05 | 1986-05-30 | Wakunaga Seiyaku Kk | ヌクレオチド誘導体 |
| US4868105A (en) * | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
| US5459255A (en) * | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US20040082774A1 (en) * | 1999-03-16 | 2004-04-29 | Guzaev Andrei P. | Novel phosphate and thiophosphate protecting groups |
| JP4945129B2 (ja) * | 2004-01-27 | 2012-06-06 | 株式会社キラルジェン | フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法 |
| JP5750209B2 (ja) * | 2007-03-16 | 2015-07-15 | アプタ バイオサイエンス リミテッド | 機能性分子、機能性分子合成用アミダイド、及び標的物質解析方法 |
| JP5548852B2 (ja) * | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| CN102191233B (zh) * | 2010-03-04 | 2014-06-04 | 中国人民解放军军事医学科学院毒物药物研究所 | 新颖的10-23脱氧核酶类似物及其用途 |
| JP2012033429A (ja) | 2010-08-02 | 2012-02-16 | Polymatech Co Ltd | 操作スイッチ |
| US9029528B2 (en) * | 2011-05-17 | 2015-05-12 | Ajinomoto Co., Inc. | Solution-based method of making oligonucleotides via phosphoramidite coupling |
| JP5760722B2 (ja) | 2011-06-09 | 2015-08-12 | 横浜ゴム株式会社 | 空気入りタイヤおよびその製造方法 |
| WO2013179412A1 (ja) * | 2012-05-30 | 2013-12-05 | 北海道システム・サイエンス株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
-
2013
- 2013-02-15 IN IN6768DEN2014 patent/IN2014DN06768A/en unknown
- 2013-02-15 EP EP17194621.3A patent/EP3296306B1/de active Active
- 2013-02-15 CN CN201610883841.0A patent/CN106977567B/zh active Active
- 2013-02-15 WO PCT/JP2013/053769 patent/WO2013122236A1/ja not_active Ceased
- 2013-02-15 CN CN201380009595.0A patent/CN104114569B/zh active Active
- 2013-02-15 JP JP2013558763A patent/JP6237237B2/ja active Active
- 2013-02-15 EP EP13749023.1A patent/EP2816053B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104114569B (zh) | 2017-04-26 |
| EP2816053A4 (de) | 2015-07-01 |
| CN106977567A (zh) | 2017-07-25 |
| CN106977567B (zh) | 2021-02-02 |
| WO2013122236A1 (ja) | 2013-08-22 |
| EP3296306B1 (de) | 2022-11-09 |
| EP2816053B1 (de) | 2021-03-24 |
| JPWO2013122236A1 (ja) | 2015-05-18 |
| EP2816053A1 (de) | 2014-12-24 |
| EP3296306A1 (de) | 2018-03-21 |
| JP6237237B2 (ja) | 2017-11-29 |
| CN104114569A (zh) | 2014-10-22 |
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