IN2014DN09127A - - Google Patents

Info

Publication number
IN2014DN09127A
IN2014DN09127A IN9127DEN2014A IN2014DN09127A IN 2014DN09127 A IN2014DN09127 A IN 2014DN09127A IN 9127DEN2014 A IN9127DEN2014 A IN 9127DEN2014A IN 2014DN09127 A IN2014DN09127 A IN 2014DN09127A
Authority
IN
India
Prior art keywords
propagation
light sheet
non diffractive
diffractive
optical system
Prior art date
Application number
Other languages
English (en)
Inventor
Kishan Dholakia
Tom Vettenburg
Original Assignee
Univ St Andrews
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1205974.7A external-priority patent/GB201205974D0/en
Priority claimed from GBGB1215169.2A external-priority patent/GB201215169D0/en
Application filed by Univ St Andrews filed Critical Univ St Andrews
Publication of IN2014DN09127A publication Critical patent/IN2014DN09127A/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6456Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458Fluorescence microscopy
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/06Means for illuminating specimens
    • G02B21/08Condensers
    • G02B21/10Condensers affording dark-field illumination
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/16Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365Control or image processing arrangements for digital or video microscopes
    • G02B21/367Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0927Systems for changing the beam intensity distribution, e.g. Gaussian to top-hat
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938Using specific optical elements
    • G02B27/0944Diffractive optical elements, e.g. gratings, holograms
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/09Beam shaping, e.g. changing the cross-sectional area, not otherwise provided for
    • G02B27/0938Using specific optical elements
    • G02B27/0988Diaphragms, spatial filters, masks for removing or filtering a part of the beam
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58Optics for apodization or superresolution; Optical synthetic aperture systems
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04NPICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N7/00Television systems
    • H04N7/18Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Nonlinear Science (AREA)
  • Optical Elements Other Than Lenses (AREA)
  • Tents Or Canopies (AREA)
IN9127DEN2014 2012-04-03 2013-03-26 IN2014DN09127A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1205974.7A GB201205974D0 (en) 2012-04-03 2012-04-03 High resolution imaging of extended volumes
GBGB1215169.2A GB201215169D0 (en) 2012-08-24 2012-08-24 High resolution imaging of extended volumes
PCT/GB2013/050788 WO2013150273A1 (fr) 2012-04-03 2013-03-26 Imagerie haute résolution de volumes étendus

Publications (1)

Publication Number Publication Date
IN2014DN09127A true IN2014DN09127A (fr) 2015-05-22

Family

ID=48095913

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9127DEN2014 IN2014DN09127A (fr) 2012-04-03 2013-03-26

Country Status (8)

Country Link
US (1) US10444520B2 (fr)
EP (1) EP2834695B1 (fr)
JP (1) JP6166776B2 (fr)
CN (1) CN104204898B (fr)
CA (1) CA2869359C (fr)
ES (1) ES2898616T3 (fr)
IN (1) IN2014DN09127A (fr)
WO (1) WO2013150273A1 (fr)

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US10539772B2 (en) 2013-10-09 2020-01-21 Howard Hughes Medical Institute Multiview light-sheet microscopy
DE102013112595B4 (de) * 2013-11-15 2024-08-01 Carl Zeiss Microscopy Gmbh Anordnung zur Lichtblattmikroskopie
DE102013021222B4 (de) * 2013-12-17 2023-05-04 Carl Zeiss Microscopy Gmbh Mikroskop und Mikroskopieverfahren
US20170038574A1 (en) * 2014-02-03 2017-02-09 President And Fellows Of Harvard College Three-dimensional super-resolution fluorescence imaging using airy beams and other techniques
DE102014102215A1 (de) * 2014-02-20 2015-08-20 Carl Zeiss Microscopy Gmbh Verfahren und Anordnung zur Lichtblattmikroskopie
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GB201508376D0 (en) 2015-05-15 2015-07-01 Univ St Andrews Light sheet imaging
EP3298449B1 (fr) 2015-05-22 2022-05-04 The Hong Kong University of Science and Technology Procédés et systèmes permettant de générer des feuilles de lumière non diffractée pour une microscopie en fluorescence multicolore
DE102015209758A1 (de) * 2015-05-28 2016-12-01 Carl Zeiss Microscopy Gmbh Anordnung und Verfahren zur Strahlformung und zur Lichtblattmikroskopie
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CN105866013A (zh) * 2016-05-26 2016-08-17 天津大学 基于两幅激光干涉成像离焦干涉图的球形粒子判别方法
WO2017223426A1 (fr) 2016-06-24 2017-12-28 Howard Hughes Medical Institute Réglage automatique de géométrie de nappe de lumière dans un microscope
CN106053346B (zh) * 2016-06-29 2018-06-08 华中科技大学 一种光片显微成像转换装置
CN106153307B (zh) * 2016-06-30 2018-09-28 河南科技大学 一种利用光强比测量Airy光束衰减因子的装置和方法
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JP7109423B2 (ja) * 2016-08-15 2022-07-29 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング ライトシート顕微鏡
CN107991766A (zh) 2016-10-26 2018-05-04 中国科学技术大学 一种具有三维成像能力的显微镜和成像方法
EP3538941B1 (fr) 2016-11-10 2025-04-23 The Trustees of Columbia University in the City of New York Procédés d'imagerie rapide de grands échantillons à haute résolution
WO2018089948A1 (fr) * 2016-11-11 2018-05-17 Cold Spring Harbor Laboratory Système et procédé pour microscope à feuille de lumière et de dégagement pour le traçage
JP7382232B2 (ja) * 2017-05-02 2023-11-16 メルク・シャープ・アンド・ドーム・エルエルシー 抗lag3抗体の製剤および抗lag3抗体と抗pd-1抗体との共製剤
CN107238590A (zh) * 2017-05-24 2017-10-10 清华大学 基于光片显微与单像素成像的显微层析成像装置
CN107144951B (zh) * 2017-06-30 2023-03-21 中国计量大学 一种基于半球微结构的超分辨显微装置
CN108303402A (zh) * 2017-12-26 2018-07-20 华中科技大学 一种大视场无衍射贝塞尔光片显微扫描成像方法及系统
EP3735606B1 (fr) * 2018-01-02 2023-03-22 King's College London Procédé et système pour microscopie de localisation
CN108398774B (zh) * 2018-01-18 2021-03-02 中国科学院广州生物医药与健康研究院 一种光片显微镜
CN108469429B (zh) 2018-02-06 2020-11-24 西安电子科技大学 一种双模态拉曼-光学投影断层成像系统
WO2019153530A1 (fr) * 2018-02-06 2019-08-15 西安电子科技大学 Système bimodal d'imagerie par tomographie à projection optique et par effet raman
US10247910B1 (en) 2018-03-14 2019-04-02 Nanotronics Imaging, Inc. Systems, devices and methods for automatic microscopic focus
US10146041B1 (en) 2018-05-01 2018-12-04 Nanotronics Imaging, Inc. Systems, devices and methods for automatic microscope focus
CN108732124B (zh) * 2018-05-21 2023-05-26 深圳市重投华讯太赫兹科技有限公司 一种三维层析成像系统及方法
CN108956562B (zh) * 2018-06-11 2020-05-22 浙江大学 一种基于重定位的光切片荧光显微成像方法和装置
CN108645831B (zh) * 2018-06-14 2020-11-20 厦门大学 多功能表面等离子体耦合发射荧光与拉曼检测仪及其检测方法
DE102018115001A1 (de) * 2018-06-21 2019-12-24 Carl Zeiss Microscopy Gmbh Verfahren zum Kalibrieren einer Phasenmaske und Mikroskop
EP3620841A1 (fr) * 2018-09-07 2020-03-11 ETH Zurich Système automatisé de microscope multiphotonique à champ large
CN109297949B (zh) * 2018-09-19 2024-04-05 上海镭立激光科技有限公司 显微影像结合透射拉曼光谱的肿瘤细胞检测方法及装置
MX2021004928A (es) 2018-10-31 2021-06-08 Merck Sharp & Dohme Llc Cristales de anticuerpo anti-pd-1 humano y metodos de uso de los mismos.
EP3876990A4 (fr) 2018-11-07 2023-09-06 Merck Sharp & Dohme LLC Co-formulations d'anticorps anti-lag3 et d'anticorps anti-pd-1
CN109656028A (zh) * 2019-01-11 2019-04-19 中国科学院广州生物医药与健康研究院 一种产生无衍射光的系统及方法
US11187659B2 (en) * 2019-03-28 2021-11-30 The Regents Of The University Of California Systems for fluorescence light sheet microscopy of large samples in high refractive index solutions
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CN115308917B (zh) * 2022-08-23 2025-07-11 浙江理工大学 一种矢量光场模间相位旋转角度随距离可调系统
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WO2006058187A2 (fr) * 2004-11-23 2006-06-01 Robert Eric Betzig Microscopie optique de reseau cristallin
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Also Published As

Publication number Publication date
JP6166776B2 (ja) 2017-07-19
CN104204898A (zh) 2014-12-10
CN104204898B (zh) 2017-12-15
EP2834695B1 (fr) 2021-08-25
ES2898616T3 (es) 2022-03-08
EP2834695A1 (fr) 2015-02-11
US10444520B2 (en) 2019-10-15
CA2869359A1 (fr) 2013-10-10
WO2013150273A1 (fr) 2013-10-10
JP2015514235A (ja) 2015-05-18
US20150029325A1 (en) 2015-01-29
CA2869359C (fr) 2021-03-23

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