IN2014DN09529A - - Google Patents

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Publication number: IN2014DN09529A
Authority: IN; India
Prior art keywords: coa; dhb; malate; converting; malyl
Prior art date: 2012-04-26

Application number

Other languages

English (en)

Inventor

Thomas Walther

Clémentine Dressaire

Hélène CORDIER

Jean-Marie Francois

Original Assignee

Adisseo France Sas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-04-26

Filing date

2013-04-25

Publication date

2015-07-17

2013-04-25 Application filed by Adisseo France Sas filed Critical Adisseo France Sas

2015-07-17 Publication of IN2014DN09529A publication Critical patent/IN2014DN09529A/en

Links

IUNJCFABHJZSKB-UHFFFAOYSA-N 2,4-Dihydroxybenzaldehyde Natural products OC1=CC=C(C=O)C(O)=C1 IUNJCFABHJZSKB-UHFFFAOYSA-N 0.000 abstract 2
HJQWLHMLMCDAEL-NALABAGVSA-N malyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)C[C@H](O)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 HJQWLHMLMCDAEL-NALABAGVSA-N 0.000 abstract 2
101710138112 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase Proteins 0.000 abstract 1
UFYGCFHQAXXBCF-UHFFFAOYSA-N 2,4-dihydroxybutanoic acid Chemical compound OCCC(O)C(O)=O UFYGCFHQAXXBCF-UHFFFAOYSA-N 0.000 abstract 1
HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 abstract 1
229940049920 malate Drugs 0.000 abstract 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
VNOYUJKHFWYWIR-FZEDXVDRSA-N succinyl-coa Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-FZEDXVDRSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01002—Alcohol dehydrogenase (NADP+) (1.1.1.2), i.e. aldehyde reductase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01076—Succinate-semialdehyde dehydrogenase (acetylating) (1.2.1.76)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/03—CoA-transferases (2.8.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03024—Malyl-CoA lyase (4.1.3.24)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
- C12Y602/01—Acid-Thiol Ligases (6.2.1)
- C12Y602/01009—Malate--CoA ligase (6.2.1.9)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01028—2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase (1.3.1.28)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)

IN9529DEN2014 2012-04-26 2013-04-25 IN2014DN09529A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2012001123		2012-04-26
PCT/IB2013/001071 WO2013160762A2 (fr)	2012-04-26	2013-04-25	Procédé de production d'acide 2,4-dihydroxybutyrique

Publications (1)

Publication Number	Publication Date
IN2014DN09529A true IN2014DN09529A (fr)	2015-07-17

Family

ID=48699857

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN9529DEN2014 IN2014DN09529A (fr)	2012-04-26	2013-04-25

Country Status (10)

Country	Link
US (1)	US9890400B2 (fr)
EP (1)	EP2841584B1 (fr)
JP (1)	JP6342385B2 (fr)
KR (1)	KR102024109B1 (fr)
CN (1)	CN104254612B (fr)
BR (1)	BR112014026149A2 (fr)
ES (1)	ES2875010T3 (fr)
IN (1)	IN2014DN09529A (fr)
MY (1)	MY175391A (fr)
WO (1)	WO2013160762A2 (fr)

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KR102093172B1 (ko) *	2012-07-11	2020-03-25	아디쎄오 프랑스 에스에이에스	2,4-다이하이드록시부티레이트의 제조 방법
CN103642765B (zh) *	2013-12-25	2015-11-18	南京工业大学	醇脱氢酶突变体及其应用
WO2015155791A2 (fr) *	2014-04-11	2015-10-15	String Bio Private Limited	Production d'acide succinique à partir de déchets organiques, de biogaz ou de méthane et à l'aide d'une bactérie méthanotrophe recombinée
CN107690482B (zh) *	2015-04-07	2022-11-29	代谢探索者公司	用于2,4-二羟基丁酸的优化生产的经修饰的微生物
ES2811337T3 (es)	2015-04-07	2021-03-11	Metabolic Explorer Sa	Microorganismo modificado para la producción optimizada de 2,4-dihidroxibutirato con eflujo de 2,4- dihidroxibutirato aumentado
CA2989434C (fr) *	2015-06-25	2023-10-03	Dynamic Food Ingredients Corporation	Procede de production d'acide 2,4-dihydroxybutyrique
CN105441372A (zh) *	2015-10-30	2016-03-30	清华大学	一种重组谷氨酸棒杆菌与应用
JP7217700B2 (ja)	2016-09-13	2023-02-03	アラーガン、インコーポレイテッド	安定化非タンパク質クロストリジウム毒素組成物
CN111778200B (zh) *	2019-04-04	2022-11-01	中国科学院微生物研究所	生产L-天冬氨酸的平台菌、基于该平台菌构建的生产β-丙氨酸的重组菌及其构建方法
CN112410389B (zh) *	2019-08-23	2023-07-18	中国科学院微生物研究所	支链α-酮酸脱氢酶复合体在制备丙二酸单酰辅酶A中的应用
CN110713962B (zh) *	2019-09-06	2022-06-21	南京农业大学	一株高产丙二酰辅酶a的基因工程菌及其构建方法和应用
DE102021101004B3 (de)	2021-01-19	2022-03-10	Technische Universität Dresden, Körperschaft des öffentlichen Rechts	Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN115820616A (zh) *	2022-07-22	2023-03-21	昆明理工大学	一种带荧光标记的噬菌体裂解酶及其应用
US12519499B2 (en) *	2022-10-26	2026-01-06	Hewlett Packard Enterprise Development Lp	Short detection and protection circuit for access point
CN115948482B (zh) *	2023-02-07	2024-02-09	中国科学院天津工业生物技术研究所	一种2，4-二羟基丁酸生物合成途径的构建方法及应用
KR102912666B1 (ko) *	2023-03-15	2026-01-15	씨제이제일제당 주식회사	Phb를 생산하는 메탄자화균 및 이를 이용한 phb의 생산방법

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2013
- 2013-04-25 MY MYPI2014002952A patent/MY175391A/en unknown
- 2013-04-25 IN IN9529DEN2014 patent/IN2014DN09529A/en unknown
- 2013-04-25 JP JP2015507618A patent/JP6342385B2/ja not_active Expired - Fee Related
- 2013-04-25 US US14/397,315 patent/US9890400B2/en active Active
- 2013-04-25 WO PCT/IB2013/001071 patent/WO2013160762A2/fr not_active Ceased
- 2013-04-25 CN CN201380022158.2A patent/CN104254612B/zh active Active
- 2013-04-25 EP EP13731871.3A patent/EP2841584B1/fr not_active Not-in-force
- 2013-04-25 BR BR112014026149A patent/BR112014026149A2/pt not_active Application Discontinuation
- 2013-04-25 KR KR1020147033085A patent/KR102024109B1/ko active Active
- 2013-04-25 ES ES13731871T patent/ES2875010T3/es active Active

Also Published As

Publication number	Publication date
KR20150013607A (ko)	2015-02-05
WO2013160762A3 (fr)	2014-01-23
CN104254612A (zh)	2014-12-31
JP6342385B2 (ja)	2018-06-13
CN104254612B (zh)	2018-06-01
WO2013160762A2 (fr)	2013-10-31
JP2015514433A (ja)	2015-05-21
KR102024109B1 (ko)	2019-09-23
MY175391A (en)	2020-06-23
US20150159182A1 (en)	2015-06-11
BR112014026149A2 (pt)	2017-07-18
ES2875010T3 (es)	2021-11-08
EP2841584B1 (fr)	2021-03-17
EP2841584A2 (fr)	2015-03-04
US9890400B2 (en)	2018-02-13

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WO2013160762A3 (fr)	2014-01-23	Procédé de production d'acide 2,4-dihydroxybutyrique
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