IN2014MN01819A - - Google Patents

Download PDF

Info

Publication number
IN2014MN01819A
IN2014MN01819A IN1819MUN2014A IN2014MN01819A IN 2014MN01819 A IN2014MN01819 A IN 2014MN01819A IN 1819MUN2014 A IN1819MUN2014 A IN 1819MUN2014A IN 2014MN01819 A IN2014MN01819 A IN 2014MN01819A
Authority
IN
India
Prior art keywords
polymeric
disclosed
active agents
therapeutically active
backbone
Prior art date
Application number
Other languages
English (en)
Inventor
Fainaro Ronit Satchi
Ela Markovsky
COHEN Hemda BAABUR
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Publication of IN2014MN01819A publication Critical patent/IN2014MN01819A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN1819MUN2014 2012-03-05 2013-03-05 IN2014MN01819A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261606557P 2012-03-05 2012-03-05
PCT/IL2013/050195 WO2013132485A1 (fr) 2012-03-05 2013-03-05 Polymères ayant des agents actifs au niveau thérapeutique conjugués à ceux-ci, procédés de préparation desdits polymères et leurs utilisations

Publications (1)

Publication Number Publication Date
IN2014MN01819A true IN2014MN01819A (fr) 2015-07-03

Family

ID=49116032

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1819MUN2014 IN2014MN01819A (fr) 2012-03-05 2013-03-05

Country Status (5)

Country Link
US (2) US9687562B2 (fr)
EP (1) EP2822598A4 (fr)
CN (1) CN104244988A (fr)
IN (1) IN2014MN01819A (fr)
WO (1) WO2013132485A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009141823A2 (fr) 2008-05-22 2009-11-26 Ramot At Tel Aviv University Ltd. Conjugués d'un polymère, d'un bisphosphonate et d'un agent anti-angiogenèse et leurs utilisations dans le traitement et la surveillance de maladies concernant les os
EP2307032A4 (fr) 2008-05-22 2014-08-20 Univ Ramot Nouveaux conjugués de polymères sur lesquels sont fixés un agent thérapeutiquement actif et une fraction ciblant l'angiogenèse et utilisations de ces conjugués pour traiter des maladies liées à l'angiogenèse
EP2300021A4 (fr) 2008-05-22 2014-10-08 Univ Ramot Conjugué d'un polymère, d'un agent anti-angiogenèse et d'une fraction de ciblage et utilisations de ce conjugué pour traiter des maladies angiogéniques osseuses
IN2014MN01819A (fr) 2012-03-05 2015-07-03 Univ Ramot
KR102135679B1 (ko) * 2013-11-19 2020-07-20 삼성전자주식회사 생분해성 폴리머를 포함하는 표적 친화성 물질 및 이의 용도
EP3267975A4 (fr) * 2015-03-09 2018-08-08 The Regents of the University of California Conjugués polymère-médicament pour une thérapie anticancéreuse d'association
CN105097941B (zh) * 2015-05-28 2019-02-26 京东方科技集团股份有限公司 一种薄膜晶体管及其制造方法、阵列基板、显示装置
WO2017068577A1 (fr) 2015-10-18 2017-04-27 Ariel-University Research And Development Company Ltd. Véhicule d'administration de médicaments multiples à base de peptides
WO2017145164A1 (fr) 2016-02-24 2017-08-31 Ramot At Tel-Aviv University Ltd. Conjugués polymères et leurs utilisations
EP3638248A4 (fr) * 2017-06-16 2021-06-30 The Regents of The University of California Conjugués de principes pharmaceutiques actifs
EP3684463B1 (fr) 2017-09-19 2025-05-14 Neuroenhancement Lab, LLC Procédé et appareil de neuro-activation
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11318277B2 (en) 2017-12-31 2022-05-03 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
JP2021510702A (ja) * 2018-01-12 2021-04-30 プロリンクス エルエルシー 相乗的がん治療
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
US11452839B2 (en) 2018-09-14 2022-09-27 Neuroenhancement Lab, LLC System and method of improving sleep
TWI744730B (zh) 2018-12-04 2021-11-01 田德揚 用於遞送抗癌劑之立體複合物
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
AU2020367821A1 (en) * 2019-10-18 2022-05-12 University Of Utah Research Foundation Polymeric drug delivery conjugates and methods of making and using thereof
CN111333835B (zh) * 2020-03-06 2021-11-05 同济大学 一种骨靶向聚合物、骨靶向聚合物囊泡及其制备方法与应用
CN119013010A (zh) * 2021-12-16 2024-11-22 艾维尔勒斯生物公司 用于治疗慢性肺病的可吸入或可摄入的乳酸组合物
WO2024054372A1 (fr) * 2022-09-09 2024-03-14 Indiana University Research And Technology Corporation Multivalence pour l'inhibition d'enzymes

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770565A (en) 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
CA2227265C (fr) 1995-08-14 2012-01-03 The Scripps Research Institute Procede et compositions utiles pour inhiber l'angiogenese mediee par .alpha.v.beta.5
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
JP4883515B2 (ja) * 1999-09-08 2012-02-22 ポリセリックス リミテッド 均一分子量ポリマー
HUP0300024A2 (en) 2000-02-24 2003-05-28 Genentech Inc Caspase activated prodrugs therapy
CA2444483A1 (fr) * 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Compositions d'imagerie diagnostique, leurs methodes de synthese et utilisation
CA2480809A1 (fr) 2002-04-11 2003-10-23 Children's Medical Center Corporation Methodes permettant d'inhiber l'hyperpermeabilite vasculaire
JP4514455B2 (ja) 2002-04-11 2010-07-28 チルドレンズ メディカル センター コーポレーション Ｔｎｐ−４７０ポリマー複合体及びその使用
US20030217320A1 (en) 2002-05-20 2003-11-20 Gorshe Steven Scott Cyclic redundancy check circuit for use with self-synchronous scramblers
WO2004062588A2 (fr) 2003-01-06 2004-07-29 University Of Utah Systeme de liberation de medicament polymerique soluble dans l'eau ciblant les os
DE10310082A1 (de) 2003-03-07 2004-09-16 Ktb Tumorforschungsgesellschaft Mbh Protein-bindende Doxorubicin-Peptid-Derivate
WO2004089925A1 (fr) 2003-04-03 2004-10-21 Semafore Pharmaceuticals, Inc. Promedicaments d'inhibiteurs de pi-3 kinase
CA2572226A1 (fr) 2004-06-28 2006-02-02 Bruce R. Line Nanohybrides radiomarques ciblant un systeme neovasculaire de la tumeur solide et procede d'utilisation associe
WO2006056889A2 (fr) 2004-10-06 2006-06-01 Tiltan Pharma Ltd Procede et composition pour renforcer une therapie anti-angiogenique
US20080248030A1 (en) 2005-02-02 2008-10-09 Children's Medical Center Corporation Method of Treating Angiogenic Diseases
US8404650B2 (en) 2005-10-28 2013-03-26 The Regents Of The University Of Colorado, A Body Corporate Methods of treating cancer with doxazolidine and prodrugs thereof
US8252740B2 (en) 2006-01-27 2012-08-28 The University Of Mississippi Medical Center Thermally-targeted delivery of medicaments including doxorubicin
CA2663375A1 (fr) 2006-09-15 2008-03-20 Onconova Therapeutics, Inc. Composes cytotoxiques actives destines a se fixer a des molecules de ciblage dans le traitement de maladies touchant des mammiferes
MX2009002855A (es) 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
US20080181852A1 (en) 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
EP2144631A2 (fr) 2007-04-10 2010-01-20 Nitto Denko Corporation Supports de médicaments multifonctionnels à base de polyglutamate
EP2155253A2 (fr) 2007-05-09 2010-02-24 Nitto Denko Corporation Conjugués de polyglutamate et conjugués de polyglutamate-amino acide contenant une pluralité de médicaments
CA2723315A1 (fr) * 2008-04-30 2009-11-05 Ben-Gurion University Of The Negev Research And Development Authority Systemes d'administration vasculaire
WO2009141823A2 (fr) * 2008-05-22 2009-11-26 Ramot At Tel Aviv University Ltd. Conjugués d'un polymère, d'un bisphosphonate et d'un agent anti-angiogenèse et leurs utilisations dans le traitement et la surveillance de maladies concernant les os
EP2300021A4 (fr) 2008-05-22 2014-10-08 Univ Ramot Conjugué d'un polymère, d'un agent anti-angiogenèse et d'une fraction de ciblage et utilisations de ce conjugué pour traiter des maladies angiogéniques osseuses
EP2307032A4 (fr) 2008-05-22 2014-08-20 Univ Ramot Nouveaux conjugués de polymères sur lesquels sont fixés un agent thérapeutiquement actif et une fraction ciblant l'angiogenèse et utilisations de ces conjugués pour traiter des maladies liées à l'angiogenèse
IN2014MN01819A (fr) 2012-03-05 2015-07-03 Univ Ramot

Also Published As

Publication number Publication date
EP2822598A1 (fr) 2015-01-14
EP2822598A4 (fr) 2016-04-13
CN104244988A (zh) 2014-12-24
US20150017115A1 (en) 2015-01-15
US9687562B2 (en) 2017-06-27
US10155047B2 (en) 2018-12-18
WO2013132485A1 (fr) 2013-09-12
US20170182176A1 (en) 2017-06-29
WO2013132485A9 (fr) 2014-04-10

Similar Documents

Publication Publication Date Title
EP2563366A4 (fr) Utilisations de conjugués phospholipidiques d'agonistes synthétiques de tlr7
ZA201505813B (en) Biologically active molecules, conjugates thereof, and therapeutic uses
EP2849797A4 (fr) Conjugués médicamenteux, procédés de conjugaison et utilisations de ceux-ci
MY173826A (en) Oligonucleotide conjugates
ZA201507218B (en) Compositins and methods for modulating apolipoprotein c-iii expression
NZ710729A (en) Amatoxin derivatives
CR20120202A (es) Métodos y composiciones para tratar cáncer
WO2012106713A3 (fr) Conjugués de nanoparticule ciblés
BR112014031421A2 (pt) composições para tratamento de câncer e métodos para produção das mesmas
MX2018013623A (es) Derivados de n-acildipeptido y sus usos.
NZ708727A (en) Conjugate compounds
MX2019003249A (es) Diagnostico, prevencion y tratamiento de enfermedades de la articulacion.
MY177912A (en) Vegf neutralizing prodrugs for the treatment of ocular conditions
EA032867B9 (ru) Оптимизированная с помощью эндосомолитических средств система доставки in vivo конъюгатов нуклеиновой кислоты
EP3331573A4 (fr) Conjugués thérapeutiques d'internalisation cellulaire
MX2012010448A (es) Conjugados de carbohidrato-poli aminoacido-farmaco.
EP2822598A4 (fr) Polymères ayant des agents actifs au niveau thérapeutique conjugués à ceux-ci, procédés de préparation desdits polymères et leurs utilisations
PH12012502129A1 (en) New combination therapy in treatment of oncological and fibrotic diseases
EP2773379A4 (fr) Administration sous-cutanée de conjugués polymères d'agents thérapeutiques
MX366090B (es) Combinación farmacéutica para usarse en mejorar la tolerancia a la glucosa en pacientes que padecen diabetes de tipo 2.
WO2015069697A3 (fr) Polythérapie
ECSP14013195A (es) Catéter, en particular catéter permanente para el tratamiento de disfunciones y/o enfermedades de la vejiga y/o la próstata.
EP2925301A4 (fr) Produit thérapeutique et immunomodulateur anticancéreux dhs1p photodynamique
WO2015040243A3 (fr) Procédés et compositions pour cibler un microenvironnement de tumeur et pour prévenir la métastase
TN2013000333A1 (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme