IN2015DN01331A - - Google Patents

Info

Publication number
IN2015DN01331A
IN2015DN01331A IN1331DEN2015A IN2015DN01331A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A IN 1331DEN2015 A IN1331DEN2015 A IN 1331DEN2015A IN 2015DN01331 A IN2015DN01331 A IN 2015DN01331A
Authority
IN
India
Prior art keywords
trifluoromethylpyridin
morpholinyl
pyrimidinyl
intermediates
amine
Prior art date
Application number
Inventor
Dietmar Flubacher
Nicole Bieri
Murat Acemoglu
Pascal Michel
Rasmus Mose
Hans Stettler
Maria Caterina Testa
Jörg Brozio
Frank Schaefer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2015DN01331A publication Critical patent/IN2015DN01331A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention discloses improved processes for manufacturing a compound, 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)- 4-trifluoromethylpyridin-2-amine, its monohydrochloride salt and intermediates thereof.
IN1331DEN2015 2012-10-23 2013-10-21 IN2015DN01331A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717237P 2012-10-23 2012-10-23
US201361842101P 2013-07-02 2013-07-02
PCT/EP2013/071996 WO2014064058A1 (en) 2012-10-23 2013-10-21 Improved process for manufacturing 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-trifluoromethylpyridin-2-amine

Publications (1)

Publication Number Publication Date
IN2015DN01331A true IN2015DN01331A (en) 2015-07-03

Family

ID=49448162

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1331DEN2015 IN2015DN01331A (en) 2012-10-23 2013-10-21

Country Status (15)

Country Link
US (1) US9637468B2 (en)
EP (1) EP2912030B1 (en)
JP (1) JP6267213B2 (en)
KR (1) KR102128127B1 (en)
CN (1) CN104736532B (en)
AU (2) AU2013336807B2 (en)
BR (1) BR112015007243B1 (en)
CA (1) CA2885471C (en)
ES (1) ES2605638T3 (en)
IN (1) IN2015DN01331A (en)
MX (1) MX360703B (en)
PL (1) PL2912030T3 (en)
PT (1) PT2912030T (en)
RU (1) RU2646760C2 (en)
WO (1) WO2014064058A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342326B (en) 2011-09-27 2016-09-26 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh.
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
CN105050602B (en) * 2013-01-12 2018-05-25 张大为 pyridine compounds as PI3 kinase inhibitors
CA2903979A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
BR112016023811B8 (en) 2014-04-22 2023-01-10 Piqur Therapeutics Ag MANUFACTURING METHOD FOR TRIAZINE, PYRIMIDINE AND PYRIDINE DERIVATIVES, THEIR INTERMEDIATES AND THEIR MANUFACTURING METHODS
CN107001317B (en) * 2014-09-29 2019-05-24 山东轩竹医药科技有限公司 Highly selective substituted pyrimidine PI3K inhibitors
CN105085476B (en) * 2014-11-24 2018-03-09 苏州晶云药物科技有限公司 Crystal formation of 5 [2,6 2 (4 morpholinyl) 4 pyrimidine radicals] 4 (trifluoromethyl) 2 pyridine amine dihydrochlorides and preparation method thereof
CN105001151B (en) * 2015-08-28 2017-07-14 苏州明锐医药科技有限公司 Bu Panixi intermediates and preparation method thereof
CN106543140A (en) * 2015-09-21 2017-03-29 苏州晶云药物科技有限公司 Crystal formation of 5- [2,6- bis- (4- morpholinyls) -4- pyrimidine radicals] -4- (trifluoromethyl) -2- pyridine amine hydrochlorates and preparation method thereof
CN107793394A (en) * 2017-08-03 2018-03-13 上海厚璞生物科技有限公司 A kind of serial key intermediate for producing selective PI3K inhibitor
CA3122182A1 (en) 2018-12-18 2020-06-25 Astrazeneca Ab Pharmaceutical process and intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4061194B2 (en) * 2001-02-08 2008-03-12 富山化学工業株式会社 6-Substituted alkylamino-3-pyridylboric acid derivatives or salts thereof and methods for producing them
DK2316831T3 (en) * 2002-11-21 2013-06-10 Novartis Ag 2- (Morpholin-4-yl) pyrimidines as phosphotidylinositol (PI) -3-kinase inhibitors and their use in the treatment of cancer
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي PI-3 Kinase inhibitors and methods of their use
CN104945373A (en) * 2010-10-01 2015-09-30 诺华有限公司 Manufacturing process for pyrimidine derivatives

Also Published As

Publication number Publication date
EP2912030A1 (en) 2015-09-02
PT2912030T (en) 2016-11-30
KR20150072408A (en) 2015-06-29
CN104736532A (en) 2015-06-24
CA2885471A1 (en) 2014-05-01
JP6267213B2 (en) 2018-01-24
KR102128127B1 (en) 2020-06-30
RU2015119259A (en) 2016-12-20
AU2013336807B2 (en) 2016-10-27
US9637468B2 (en) 2017-05-02
AU2016238941A1 (en) 2016-11-03
BR112015007243A2 (en) 2017-07-04
JP2016502510A (en) 2016-01-28
AU2013336807A1 (en) 2015-03-05
US20150246897A1 (en) 2015-09-03
RU2646760C2 (en) 2018-03-07
EP2912030B1 (en) 2016-08-31
CA2885471C (en) 2021-02-23
MX2015005188A (en) 2015-09-07
ES2605638T3 (en) 2017-03-15
MX360703B (en) 2018-11-14
PL2912030T3 (en) 2017-02-28
WO2014064058A1 (en) 2014-05-01
CN104736532B (en) 2017-04-05
BR112015007243B1 (en) 2022-02-08

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