IS5391A - Pyrrolopyrrolone derivatives that inhibit the elastase neutralization - Google Patents

Pyrrolopyrrolone derivatives that inhibit the elastase neutralization

Info

Publication number: IS5391A
Authority: IS; Iceland
Prior art keywords: elastase; neutralization; inhibit; pyrrolopyrrolone; derivatives
Prior art date: 1997-09-09

Application number

IS5391A

Other languages

Icelandic (is)

Inventor

Duke Edward Clarke Geoffrey

Dennis Dowle Michael

Finch Harry

Andrew Harrison Lee

George Adam Inglis Graham

Redpath Johnson Martin

John Fawcett Macdonald Simon

Shah Pritom

Andrew Smith Robin

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

2000-02-29

Publication date

2000-02-29

1997-09-09 Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en

1997-09-09 Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en

1997-09-10 Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en

1998-02-21 Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en

2000-02-29 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2000-02-29 Publication of IS5391A publication Critical patent/IS5391A/en

Links

ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
102000016387 Pancreatic elastase Human genes 0.000 title 1
108010067372 Pancreatic elastase Proteins 0.000 title 1
238000006386 neutralization reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

IS5391A 1997-09-09 2000-02-29 Pyrrolopyrrolone derivatives that inhibit the elastase neutralization IS5391A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9719189.4A GB9719189D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GBGB9719183.7A GB9719183D0 (en)	1997-09-09	1997-09-09	Compounds
GBGB9719290.0A GB9719290D0 (en)	1997-09-10	1997-09-10	Compounds
GBGB9803611.4A GB9803611D0 (en)	1998-02-21	1998-02-21	Compounds
PCT/EP1998/005609 WO1999012933A2 (en)	1997-09-09	1998-09-07	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Publications (1)

Publication Number	Publication Date
IS5391A true IS5391A (en)	2000-02-29

Family

ID=27451698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS5391A IS5391A (en)	1997-09-09	2000-02-29	Pyrrolopyrrolone derivatives that inhibit the elastase neutralization

Country Status (24)

Country	Link
EP (1)	EP1003748A2 (en)
JP (1)	JP2001515904A (en)
KR (1)	KR20010023766A (en)
CN (1)	CN1278820A (en)
AP (1)	AP2000001761A0 (en)
AR (1)	AR017072A1 (en)
AU (1)	AU9741298A (en)
BR (1)	BR9812062A (en)
CA (1)	CA2303176A1 (en)
CO (1)	CO4970719A1 (en)
EA (1)	EA200000204A1 (en)
EE (1)	EE200000138A (en)
HU (1)	HUP0004644A3 (en)
ID (1)	ID24452A (en)
IL (1)	IL134791A0 (en)
IS (1)	IS5391A (en)
MA (1)	MA26543A1 (en)
NO (1)	NO20001198L (en)
NZ (1)	NZ503130A (en)
PE (1)	PE107899A1 (en)
PL (1)	PL339176A1 (en)
SK (1)	SK3192000A3 (en)
TR (1)	TR200000907T2 (en)
WO (1)	WO1999012933A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
ATE490959T1 (en)	2004-03-31	2010-12-15	Janssen Pharmaceutica Nv	HETEROCYCLIC NONIMIDAZOLE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
DE102004024772A1 (en) *	2004-05-17	2005-12-22	Grünenthal GmbH	Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides
TWI355380B (en)	2004-05-27	2012-01-01	Nihon Nohyaku Co Ltd	Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (en) *	2004-05-27	2012-01-11	日本農薬株式会社	Substituted pyrazinecarboxylic acid anilide derivatives or salts thereof, intermediates thereof, agricultural and horticultural agents, and methods of use thereof
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
AP2007003979A0 (en)	2004-11-23	2007-06-30	Warner Lambert Co	7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
DE602007009095D1 (en)	2006-05-04	2010-10-21	Pulmagen Therapeutics Inflamma	TETRAHYDROPYRROLOPYRIMIDINDIONE AND ITS USE AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE
GB2452696B (en)	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
WO2009060206A1 (en) *	2007-11-07	2009-05-14	Argenta Discovery Limited	3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) *	2010-02-26	2011-09-01	The University Of Hong Kong	Compositions and methods for treating chronic respiratory inflammation
JP7672641B2 (en)	2019-09-17	2025-05-08	メレオバイオファーマ４リミテッド	Alverestat for use in the treatment of transplant rejection, bronchiolitis obliterans syndrome, and graft-versus-host disease
IL297211B2 (en)	2020-04-16	2025-12-01	Mereo Biopharma 4 Ltd	Methods involving the neutrophil elastase inhibitor alblastat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (en)	2021-10-20	2024-06-21	메레오 바이오파마 4 리미티드	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
CA2250209A1 (en) *	1996-03-28	1997-10-09	Glaxo Group Limited	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/en not_active Application Discontinuation
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/en not_active Application Discontinuation
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 CN CN98810954A patent/CN1278820A/en active Pending
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/en unknown
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/en not_active Ceased
- 1998-09-07 EA EA200000204A patent/EA200000204A1/en unknown
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/en unknown
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/en not_active Withdrawn
- 1998-09-07 AR ARP980104458A patent/AR017072A1/en unknown
- 1998-09-07 EP EP98951348A patent/EP1003748A2/en not_active Withdrawn
- 1998-09-07 PL PL98339176A patent/PL339176A1/en not_active Application Discontinuation
- 1998-09-07 IL IL13479198A patent/IL134791A0/en unknown
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 MA MA25243A patent/MA26543A1/en unknown
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/en active Pending
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/en unknown
- 1998-09-07 EE EEP200000138A patent/EE200000138A/en unknown
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 ID IDW20000445A patent/ID24452A/en unknown
- 1998-09-07 CA CA002303176A patent/CA2303176A1/en not_active Abandoned
- 1998-09-08 CO CO98051488A patent/CO4970719A1/en unknown
2000
- 2000-02-29 IS IS5391A patent/IS5391A/en unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
TR200000907T2 (en)	2000-11-21
PE107899A1 (en)	1999-11-17
CO4970719A1 (en)	2000-11-07
AU9741298A (en)	1999-03-29
ID24452A (en)	2000-07-20
EE200000138A (en)	2001-02-15
MA26543A1 (en)	2004-12-20
PL339176A1 (en)	2000-12-04
CA2303176A1 (en)	1999-03-18
WO1999012933A2 (en)	1999-03-18
AP2000001761A0 (en)	2000-03-31
IL134791A0 (en)	2001-04-30
SK3192000A3 (en)	2001-03-12
WO1999012933A3 (en)	1999-05-27
JP2001515904A (en)	2001-09-25
AR017072A1 (en)	2001-08-22
NZ503130A (en)	2001-08-31
BR9812062A (en)	2000-09-26
HUP0004644A3 (en)	2002-01-28
NO20001198L (en)	2000-05-08
CN1278820A (en)	2001-01-03
HUP0004644A2 (en)	2001-09-28
EP1003748A2 (en)	2000-05-31
KR20010023766A (en)	2001-03-26
EA200000204A1 (en)	2000-10-30
NO20001198D0 (en)	2000-03-08

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