IS5394A - Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa - Google Patents
Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasaInfo
- Publication number
- IS5394A IS5394A IS5394A IS5394A IS5394A IS 5394 A IS5394 A IS 5394A IS 5394 A IS5394 A IS 5394A IS 5394 A IS5394 A IS 5394A IS 5394 A IS5394 A IS 5394A
- Authority
- IS
- Iceland
- Prior art keywords
- elastase
- neutralization
- inhibit
- pyrrolopyrrolone
- derivatives
- Prior art date
Links
- ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
- 102000016387 Pancreatic elastase Human genes 0.000 title 1
- 108010067372 Pancreatic elastase Proteins 0.000 title 1
- 238000006386 neutralization reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9719187.8A GB9719187D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
| PCT/EP1998/005604 WO1999012931A1 (en) | 1997-09-09 | 1998-09-07 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS5394A true IS5394A (is) | 2000-03-03 |
Family
ID=10818820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5394A IS5394A (is) | 1997-09-09 | 2000-03-03 | Pýrrólópýrrólón afleiður sem latar fyrir hlutleysiskirnings elastasa |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6228853B1 (is) |
| EP (1) | EP1019406A1 (is) |
| JP (1) | JP2001515902A (is) |
| KR (1) | KR20010023830A (is) |
| CN (1) | CN1278821A (is) |
| AP (1) | AP2000001760A0 (is) |
| AU (1) | AU9536098A (is) |
| BR (1) | BR9811651A (is) |
| CA (1) | CA2303249A1 (is) |
| EA (1) | EA200000205A1 (is) |
| EE (1) | EE200000137A (is) |
| GB (1) | GB9719187D0 (is) |
| HR (1) | HRP20000136A2 (is) |
| HU (1) | HUP0003475A3 (is) |
| ID (1) | ID24364A (is) |
| IL (1) | IL134935A0 (is) |
| IS (1) | IS5394A (is) |
| MA (1) | MA26544A1 (is) |
| NO (1) | NO20001200L (is) |
| PL (1) | PL339186A1 (is) |
| SK (1) | SK3242000A3 (is) |
| TR (1) | TR200001026T2 (is) |
| WO (1) | WO1999012931A1 (is) |
| ZA (1) | ZA988162B (is) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| US9034653B2 (en) | 2009-12-11 | 2015-05-19 | Quest Diagnostics Investments Inc. | Mass spectrometry of steroidal compounds in multiplexed patient samples |
| JP6113504B2 (ja) | 2009-12-11 | 2017-04-12 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| WO2021053058A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| LT4106757T (lt) | 2020-04-16 | 2023-11-10 | Mereo Biopharma 4 Limited | Neutrofilų elastazės inhibitoriaus alvelestato panaudojimas kvėpavimo sistemos ligų, nulemtų alfa-1 antitripsino nepakankamumo, gydymui |
| JP2024540952A (ja) | 2021-10-20 | 2024-11-06 | メレオ バイオファーマ ４ リミテッド | 線維化の治療における使用のための好中球エラスターゼ阻害剤 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983245A (en) * | 1975-02-06 | 1976-09-28 | Smithkline Corporation | Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes |
| GB8512230D0 (en) * | 1985-05-14 | 1985-06-19 | Shell Internationale Researche | Preparation of carboxylic acid salt |
| GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| GB9402680D0 (en) | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
| JP4163254B2 (ja) | 1996-01-03 | 2008-10-08 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ムチリンのカルバモイルオキシ誘導体および抗細菌剤としてのそれらの使用 |
| EA001437B1 (ru) | 1996-03-28 | 2001-02-26 | Глаксо Груп Лимитед | Производные пирролопирролона в качестве ингибиторов нейтрофильной эластазы |
-
1997
- 1997-09-09 GB GBGB9719187.8A patent/GB9719187D0/en not_active Ceased
-
1998
- 1998-09-07 AP APAP/P/2000/001760A patent/AP2000001760A0/en unknown
- 1998-09-07 HU HU0003475A patent/HUP0003475A3/hu unknown
- 1998-09-07 EE EEP200000137A patent/EE200000137A/xx unknown
- 1998-09-07 ID IDW20000665A patent/ID24364A/id unknown
- 1998-09-07 WO PCT/EP1998/005604 patent/WO1999012931A1/en not_active Ceased
- 1998-09-07 JP JP2000510738A patent/JP2001515902A/ja active Pending
- 1998-09-07 BR BR9811651-7A patent/BR9811651A/pt not_active Application Discontinuation
- 1998-09-07 AU AU95360/98A patent/AU9536098A/en not_active Abandoned
- 1998-09-07 PL PL98339186A patent/PL339186A1/xx not_active Application Discontinuation
- 1998-09-07 CA CA002303249A patent/CA2303249A1/en not_active Abandoned
- 1998-09-07 ZA ZA9808162A patent/ZA988162B/xx unknown
- 1998-09-07 IL IL13493598A patent/IL134935A0/xx unknown
- 1998-09-07 EP EP98948905A patent/EP1019406A1/en not_active Withdrawn
- 1998-09-07 TR TR2000/01026T patent/TR200001026T2/xx unknown
- 1998-09-07 CN CN98810967A patent/CN1278821A/zh active Pending
- 1998-09-07 HR HR20000136A patent/HRP20000136A2/hr not_active Application Discontinuation
- 1998-09-07 EA EA200000205A patent/EA200000205A1/ru unknown
- 1998-09-07 KR KR1020007002505A patent/KR20010023830A/ko not_active Withdrawn
- 1998-09-07 SK SK324-2000A patent/SK3242000A3/sk unknown
- 1998-09-07 US US09/508,326 patent/US6228853B1/en not_active Expired - Fee Related
- 1998-09-07 MA MA25244A patent/MA26544A1/fr unknown
-
2000
- 2000-03-03 IS IS5394A patent/IS5394A/is unknown
- 2000-03-08 NO NO20001200A patent/NO20001200L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20001200D0 (no) | 2000-03-08 |
| EP1019406A1 (en) | 2000-07-19 |
| TR200001026T2 (tr) | 2000-09-21 |
| EA200000205A1 (ru) | 2000-10-30 |
| NO20001200L (no) | 2000-05-08 |
| HUP0003475A3 (en) | 2002-01-28 |
| WO1999012931A1 (en) | 1999-03-18 |
| PL339186A1 (en) | 2000-12-04 |
| CN1278821A (zh) | 2001-01-03 |
| KR20010023830A (ko) | 2001-03-26 |
| BR9811651A (pt) | 2000-08-08 |
| HUP0003475A2 (hu) | 2001-09-28 |
| SK3242000A3 (en) | 2001-03-12 |
| HRP20000136A2 (en) | 2000-08-31 |
| ZA988162B (en) | 2000-03-22 |
| IL134935A0 (en) | 2001-05-20 |
| JP2001515902A (ja) | 2001-09-25 |
| ID24364A (id) | 2000-07-13 |
| US6228853B1 (en) | 2001-05-08 |
| CA2303249A1 (en) | 1999-03-18 |
| AP2000001760A0 (en) | 2000-03-31 |
| AU9536098A (en) | 1999-03-29 |
| EE200000137A (et) | 2001-02-15 |
| GB9719187D0 (en) | 1997-11-12 |
| MA26544A1 (fr) | 2004-12-20 |
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