IS6443A - Pyrido [2,3-d] pyrimidine-2,7-diamine kinase inhibitors - Google Patents

Pyrido [2,3-d] pyrimidine-2,7-diamine kinase inhibitors

Info

Publication number: IS6443A
Authority: IS; Iceland
Prior art keywords: pyrido; pyrimidine; diamine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

IS6443A

Other languages

Icelandic (is)

Inventor

John Booth Richard

Myra Dobrusin Ellen

Prasad Venkata Nagendra Josyula Vara

Joseph Mcnamara Dennis

Laurence Toogood Peter

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2002-06-25

Publication date

2002-06-25

2002-06-25 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2002-06-25 Publication of IS6443A publication Critical patent/IS6443A/en

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
QRRCMVPZJCHBLQ-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-2,7-diamine Chemical compound C1=NC(N)=NC2=NC(N)=CC=C21 QRRCMVPZJCHBLQ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

IS6443A 2000-01-25 2002-06-25 Pyrido [2,3-d] pyrimidine-2,7-diamine kinase inhibitors IS6443A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
IS6443A true IS6443A (en)	2002-06-25

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6443A IS6443A (en)	2000-01-25	2002-06-25	Pyrido [2,3-d] pyrimidine-2,7-diamine kinase inhibitors

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (en)
JP (1)	JP4047010B2 (en)
KR (1)	KR20020065939A (en)
CN (1)	CN1395578A (en)
AP (1)	AP2002002586A0 (en)
AR (1)	AR030044A1 (en)
AU (1)	AU2542501A (en)
BG (1)	BG106850A (en)
BR (1)	BR0107751A (en)
CA (1)	CA2397961C (en)
CO (1)	CO5261549A1 (en)
CR (1)	CR6706A (en)
CZ (1)	CZ20022475A3 (en)
DZ (1)	DZ3266A1 (en)
EA (1)	EA200200643A1 (en)
EE (1)	EE200200405A (en)
GT (1)	GT200100016A (en)
HN (1)	HN2001000013A (en)
HU (1)	HUP0204141A3 (en)
IL (1)	IL150545A0 (en)
IS (1)	IS6443A (en)
MA (1)	MA26868A1 (en)
MX (1)	MXPA02007221A (en)
NO (1)	NO20023527L (en)
OA (1)	OA12161A (en)
PA (1)	PA8510701A1 (en)
PE (1)	PE20011066A1 (en)
PL (1)	PL356802A1 (en)
SK (1)	SK10632002A3 (en)
SV (1)	SV2002000294A (en)
TN (1)	TNSN01014A1 (en)
WO (1)	WO2001055147A1 (en)
YU (1)	YU50402A (en)
ZA (1)	ZA200205879B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
EP2404603A1 (en)	2000-10-23	2012-01-11	Glaxosmithkline LLC	Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds for the treatment of CSBP/p38 kinase mediated diseases
PE20030008A1 (en) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	DUAL INHIBITORS OF PDE 7 AND PDE 4
MXPA04010267A (en)	2002-04-19	2005-02-03	Smithkline Beecham Corp	Novel compounds.
KR20050084027A (en) *	2002-11-28	2005-08-26	쉐링 악티엔게젤샤프트	Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en) *	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (en)	2004-07-15	2007-11-23	Sanofi Synthelabo	PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
US7550589B2 (en) *	2004-09-21	2009-06-23	Hoffman-La Roche Inc.	6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors
PE20061351A1 (en)	2005-03-25	2007-01-14	Glaxo Group Ltd	8H-PYRID [2,3-d] PYRIMIDIN-7-ONA 2,4,8-TRISUSTITUTED COMPOUNDS AS CSBP / RK / p38 KINASE INHIBITORS
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
TW200724142A (en)	2005-03-25	2007-07-01	Glaxo Group Ltd	Novel compounds
EP1865959A2 (en)	2005-03-25	2007-12-19	Glaxo Group Limited	Process for preparing pyridoý2,3-d¨pyrimidin-7-one and 3,4-dihydropyrimidoý4,5-d¨pyrimidin-2(1h)-one derivatives
FR2887882B1 (en) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
WO2007009911A1 (en) *	2005-07-21	2007-01-25	F. Hoffmann-La Roche Ag	PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
AU2006279992A1 (en)	2005-08-09	2007-02-22	Irm Llc	Compounds and compositions as protein kinase inhibitors
FR2896246B1 (en)	2006-01-13	2008-08-15	Sanofi Aventis Sa	PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (en)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	MAPK/ERK Kinase Inhibitors
FR2910813B1 (en) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
EA201100879A1 (en) *	2008-12-01	2012-01-30	Мерк Патент Гмбх	PYRIDOPYRIMIDINE DERIVATIVES AS AUTOTAXIN INHIBITORS
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
EP3733184B1 (en) *	2013-03-14	2023-08-30	Icahn School of Medicine at Mount Sinai	Pyrimidine compounds for use in the treatment of cancer
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (en) *	2014-09-02	2016-11-02	한국원자력의학원	Pyrimidine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof
CN107286180B (en) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	Heteropyridopyrimidinone derivatives as CDK inhibitors and their applications
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
MX9702245A (en) *	1994-11-14	1997-06-28	Warner Lambert Co	6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION.
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EE200000706A (en) *	1998-05-26	2002-06-17	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cell proliferation

2001
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Ceased
- 2001-01-23 EE EEP200200405A patent/EE200200405A/en unknown
- 2001-01-23 YU YU50402A patent/YU50402A/en unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/en unknown
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/en unknown
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/en active
- 2001-01-23 EA EA200200643A patent/EA200200643A1/en unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 AR ARP010100285A patent/AR030044A1/en not_active Application Discontinuation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/en unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/en not_active Application Discontinuation
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/en not_active Application Discontinuation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/en not_active IP Right Cessation
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/en not_active Expired - Fee Related
- 2001-01-23 GT GT200100016A patent/GT200100016A/en unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/en not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 PL PL01356802A patent/PL356802A1/en not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/en not_active Ceased
- 2001-01-23 CN CN01804048A patent/CN1395578A/en active Pending
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/en unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/en not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/en not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/en unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/en unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/en unknown
- 2002-06-25 IS IS6443A patent/IS6443A/en unknown
- 2002-07-17 CR CR6706A patent/CR6706A/en not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/en unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
TNSN01014A1 (en)	2005-11-10
NO20023527L (en)	2002-09-10
PL356802A1 (en)	2004-07-12
CZ20022475A3 (en)	2003-03-12
AP2002002586A0 (en)	2002-09-30
JP2003523357A (en)	2003-08-05
WO2001055147A1 (en)	2001-08-02
EA200200643A1 (en)	2002-12-26
CN1395578A (en)	2003-02-05
EP1254137A1 (en)	2002-11-06
CA2397961C (en)	2008-08-26
YU50402A (en)	2005-11-28
MA26868A1 (en)	2004-12-20
CA2397961A1 (en)	2001-08-02
NO20023527D0 (en)	2002-07-24
OA12161A (en)	2006-05-08
KR20020065939A (en)	2002-08-14
BG106850A (en)	2003-02-28
CO5261549A1 (en)	2003-03-31
DZ3266A1 (en)	2001-08-02
HUP0204141A2 (en)	2003-04-28
GT200100016A (en)	2001-10-19
AU2542501A (en)	2001-08-07
IL150545A0 (en)	2003-02-12
BR0107751A (en)	2002-11-12
HUP0204141A3 (en)	2005-03-29
SV2002000294A (en)	2002-07-16
SK10632002A3 (en)	2003-06-03
HN2001000013A (en)	2001-06-18
AR030044A1 (en)	2003-08-13
ZA200205879B (en)	2003-09-29
PA8510701A1 (en)	2002-12-11
CR6706A (en)	2005-04-04
MXPA02007221A (en)	2002-11-29
EE200200405A (en)	2003-12-15
PE20011066A1 (en)	2001-10-22
JP4047010B2 (en)	2008-02-13

Publication	Publication Date	Title
DZ3266A1 (en)	2001-08-02	PYRIDO [2,3-D] PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
PL358271A1 (en)	2004-08-09	5-alkylpyrido [2,3-D] pyrimidines as tyrosine kinase inhibitors
DK1416935T3 (en)	2008-07-07	4-Amino-6-phenyl-pyrrolo [2,3-d] pyrimidine derivatives
DK1235830T3 (en)	2004-03-29	Pyrrolo [2,3-d] pyrimidine compounds as protein kinase inhibitors
DE60016615D1 (en)	2005-01-13	Pyrazolo [4,3-D] PYRIMIDINE DERIVATIVES
ATE309245T1 (en)	2005-11-15	5-AMINO-5-PHENYL-7-CYCLOBUTYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
DE60130463D1 (en)	2007-10-25	PYRIMIDINE DERIVATIVES
MA26819A1 (en)	2004-12-20	PTERIDINONES AS KINASE INHIBITORS.
DE50001191D1 (en)	2003-03-06	PYRAZOLO [4, 3-D] PYRIMIDINE
NO20026247L (en)	2002-12-27	5-Aminoalkyl-pyrazolo [4,3-d] pyrimidines with a phosphodiesterase V inhibitory effect
DK1294729T3 (en)	2005-01-17	2-aminoalkyl-thieno [2,3-d] pyrimidines
PT1326866E (en)	2005-08-31	SUBSTITUTED 3,4-DIHYDROPYRIDO [1,2-A] PYRIMIDINES
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
DK1326866T3 (en)	2005-08-01	Substituted 3,4-dihydro-pyrido [1,2-a] pyrimidines