IS6698A - Háhreinsaðar símvastatínblöndur - Google Patents

Háhreinsaðar símvastatínblöndur

Info

Publication number: IS6698A
Authority: IS; Iceland
Prior art keywords: preparations; simvastatin; purity; purity simvastatin; simvastatin preparations
Prior art date: 2000-07-27

Application number

IS6698A

Other languages

English (en)

Inventor

Csaba Szabo

Korodi Ferenc

Istvan Melczer

Salyi Szabolcs

Leonov David

Original Assignee

Plus Chemicals, B.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-27

Filing date

2003-01-24

Publication date

2003-01-24

2003-01-24 Application filed by Plus Chemicals, B.V. filed Critical Plus Chemicals, B.V.

2003-01-24 Publication of IS6698A publication Critical patent/IS6698A/is

Links

RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title 1
229960002855 simvastatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pyrane Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IS6698A 2000-07-27 2003-01-24 Háhreinsaðar símvastatínblöndur IS6698A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22111200P	2000-07-27	2000-07-27
PCT/US2001/023525 WO2002009697A1 (en)	2000-07-27	2001-07-26	Highly purified simvastatin compositions

Publications (1)

Publication Number	Publication Date
IS6698A true IS6698A (is)	2003-01-24

Family

ID=22826406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6698A IS6698A (is)	2000-07-27	2003-01-24	Háhreinsaðar símvastatínblöndur

Country Status (20)

Country	Link
US (1)	US6686481B2 (is)
EP (1)	EP1303268A4 (is)
JP (1)	JP2004505045A (is)
KR (1)	KR100542094B1 (is)
CN (1)	CN1446088A (is)
AU (2)	AU8298101A (is)
CA (1)	CA2419206A1 (is)
CZ (1)	CZ2003554A3 (is)
HR (1)	HRP20030109A2 (is)
HU (1)	HUP0302963A3 (is)
IL (1)	IL154068A0 (is)
IS (1)	IS6698A (is)
MX (1)	MXPA03000748A (is)
NZ (1)	NZ524418A (is)
PL (1)	PL365691A1 (is)
RU (1)	RU2275909C2 (is)
SK (1)	SK2172003A3 (is)
WO (1)	WO2002009697A1 (is)
YU (1)	YU101402A (is)
ZA (1)	ZA200300344B (is)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100435078B1 (ko) *	2002-02-08	2004-06-09	종근당바이오 주식회사	심바스타틴의 정제방법
KR100502834B1 (ko) *	2002-03-25	2005-07-20	보령제약 주식회사	개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
WO2004071456A2 (en) *	2003-02-11	2004-08-26	Plus Chemicals, B.V.	Process for preparing simvastatin having controlled ranges of simvastatin dimer content
EP1563837A1 (en) *	2004-02-03	2005-08-17	Ferrer Internacional, S.A.	Hypocholesterolemic compositions comprising a statin and an antiflatulent agent
US9597289B2 (en) *	2006-04-26	2017-03-21	Rosemont Pharmaceuticals Ltd.	Liquid oral simvastatin compositions
EP2024341B1 (en)	2006-05-03	2015-12-02	MSN Laboratories Private Limited	Novel process for statins and its pharmaceutically acceptable salts thereof
BRPI0711889B8 (pt) *	2006-05-24	2021-05-25	Univ California	método para produção de sinvastatina, composição de matéria, método para fabricação de huvastatina, método para fabricação de sinvastatina, e método para fabricação de uma composição de matéria de sinvastatina ou huvastatina
US8404841B2 (en)	2006-10-09	2013-03-26	Msn Laboratories Limited	Process for the preparation of statins and their pharmaceutically acceptable salts thereof
JP2009114121A (ja) *	2007-11-06	2009-05-28	Kaneka Corp	シンバスタチンの製造方法
WO2010089770A2 (en)	2009-01-19	2010-08-12	Msn Laboratories Limited	Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
US8987444B2 (en)	2010-01-18	2015-03-24	Msn Laboratories Private Limited	Process for the preparation of amide intermediates and their use thereof
CN103864611B (zh) *	2013-12-24	2015-11-11	深圳华润九新药业有限公司	一种辛伐他汀羟基酸化物的制备方法、组合物、组合物的制备方法及其应用
CN105147659A (zh) *	2013-12-24	2015-12-16	深圳华润九新药业有限公司	一种洛伐他汀羟基酸化物的应用
US10434106B2 (en)	2017-05-19	2019-10-08	Warsaw Orthopedic, Inc.	Oxysterol-statin compounds for bone growth

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4293496A (en)	1980-02-04	1981-10-06	Merck & Co., Inc.	6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
US4444784A (en)	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
US4582915A (en) *	1983-10-11	1986-04-15	Merck & Co., Inc.	Process for C-methylation of 2-methylbutyrates
US4820850A (en)	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5223415A (en) *	1990-10-15	1993-06-29	Merck & Co., Inc.	Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
US5159104A (en)	1991-05-01	1992-10-27	Merck & Co., Inc.	Process to simvastatin ester
US5393893A (en)	1993-11-08	1995-02-28	Apotex, Inc.	Process for producing simvastatin and analogs thereof
ES2266671T3 (es) *	1997-01-28	2007-03-01	Plus Chemicals B.V.	Proceso para la produccion de estatinas semisinteticas a traves de nuevos intermediarios.
SI9800057A (sl)	1998-02-26	1999-08-31	Krka, Tovarna Zdravil, D.D.	Postopek za pripravo simvastatina in njegovih derivatov
EP0940395A1 (en)	1998-03-05	1999-09-08	Synthon B.V.	Process for producing simvastatin and/or its derivatives
NO991045L (no) *	1998-03-05	1999-09-06	Synthon Bv	FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater

2001
- 2001-07-26 CZ CZ2003554A patent/CZ2003554A3/cs unknown
- 2001-07-26 CA CA002419206A patent/CA2419206A1/en not_active Abandoned
- 2001-07-26 YU YU101402A patent/YU101402A/sh unknown
- 2001-07-26 HU HU0302963A patent/HUP0302963A3/hu unknown
- 2001-07-26 PL PL01365691A patent/PL365691A1/xx not_active Application Discontinuation
- 2001-07-26 AU AU8298101A patent/AU8298101A/xx active Pending
- 2001-07-26 JP JP2002515250A patent/JP2004505045A/ja active Pending
- 2001-07-26 US US09/916,662 patent/US6686481B2/en not_active Expired - Fee Related
- 2001-07-26 AU AU2001282981A patent/AU2001282981B2/en not_active Ceased
- 2001-07-26 HR HR20030109A patent/HRP20030109A2/hr not_active Application Discontinuation
- 2001-07-26 WO PCT/US2001/023525 patent/WO2002009697A1/en not_active Ceased
- 2001-07-26 RU RU2003105219/15A patent/RU2275909C2/ru not_active IP Right Cessation
- 2001-07-26 IL IL15406801A patent/IL154068A0/xx unknown
- 2001-07-26 EP EP01961736A patent/EP1303268A4/en not_active Withdrawn
- 2001-07-26 NZ NZ52441801A patent/NZ524418A/xx unknown
- 2001-07-26 SK SK217-2003A patent/SK2172003A3/sk not_active Application Discontinuation
- 2001-07-26 MX MXPA03000748A patent/MXPA03000748A/es active IP Right Grant
- 2001-07-26 KR KR1020037001063A patent/KR100542094B1/ko not_active Expired - Fee Related
- 2001-07-26 CN CN01814108A patent/CN1446088A/zh active Pending
2003
- 2003-01-13 ZA ZA200300344A patent/ZA200300344B/en unknown
- 2003-01-24 IS IS6698A patent/IS6698A/is unknown

Also Published As

Publication number	Publication date
PL365691A1 (en)	2005-01-10
KR20030047995A (ko)	2003-06-18
RU2275909C2 (ru)	2006-05-10
CA2419206A1 (en)	2002-02-07
EP1303268A4 (en)	2006-08-09
HUP0302963A2 (hu)	2003-12-29
EP1303268A1 (en)	2003-04-23
AU8298101A (en)	2002-02-13
AU2001282981B2 (en)	2004-08-05
JP2004505045A (ja)	2004-02-19
IL154068A0 (en)	2003-07-31
NZ524418A (en)	2004-12-24
US20020115712A1 (en)	2002-08-22
US6686481B2 (en)	2004-02-03
CN1446088A (zh)	2003-10-01
HUP0302963A3 (en)	2004-03-01
YU101402A (sh)	2006-01-16
CZ2003554A3 (cs)	2003-08-13
KR100542094B1 (ko)	2006-01-11
ZA200300344B (en)	2004-01-21
HRP20030109A2 (en)	2005-02-28
MXPA03000748A (es)	2004-06-25
SK2172003A3 (en)	2003-06-03
WO2002009697A1 (en)	2002-02-07

Publication	Publication Date	Title
NO20071303L (no)	2001-07-27	Farmasoytiske preparater
EP1329217A4 (en)	2007-04-04	Solid preparations
NO20033556D0 (no)	2003-08-11	Farmasöytiske preparater
IS6040A (is)	2001-08-07	Valdekoxib efnablöndur
NO20031483L (no)	2003-05-28	Vaksine
ATE290000T1 (de)	2005-03-15	Muscarinagonisten
ATE252099T1 (de)	2003-11-15	Biarylcarboxamide
DZ3409A1 (fr)	2002-02-21	Association therapeuthique
DE50104433D1 (de)	2004-12-09	Desodorierende Zubereitungen
NO20024172L (no)	2002-11-01	Vaksine
ATA2932001A (de)	2004-11-15	Schneefräse
ID30187A (id)	2001-11-15	Dongkrak jenis pantagraf
NO20030917D0 (no)	2003-02-27	Anvendelse
DK1278416T3 (da)	2004-07-26	Flydende præparater
ATE262530T1 (de)	2004-04-15	Indolochinazolinone
IS6698A (is)	2003-01-24	Háhreinsaðar símvastatínblöndur
AR028336A1 (es)	2003-05-07	4-hidroxi-tetrahidropiridonas fenilsubstituidas
DK1331972T3 (da)	2007-11-05	Farmaceutiske præparater
AR028061A1 (es)	2003-04-23	2-enamino-cetonitrilos fenil-substituidos
AR027931A1 (es)	2003-04-16	Antitranspirantes
ATE476423T1 (de)	2010-08-15	Benzoylpyridazine
AR027982A1 (es)	2003-04-23	Aril- y heteroarilsulfonatos
ATE284887T1 (de)	2005-01-15	Thienopyrrolidinone
DE50009295D1 (de)	2005-02-24	Vernetzerfreie zubereitungen
AT500246B8 (de)	2007-02-15	Chokerring