IS7915A - Process for the production of doloxetine and intermediates for use in the process - Google Patents

Process for the production of doloxetine and intermediates for use in the process

Info

Publication number
IS7915A
IS7915A IS7915A IS7915A IS7915A IS 7915 A IS7915 A IS 7915A IS 7915 A IS7915 A IS 7915A IS 7915 A IS7915 A IS 7915A IS 7915 A IS7915 A IS 7915A
Authority
IS
Iceland
Prior art keywords
acid addition
addition salt
duloxetine
doloxetine
intermediates
Prior art date
Application number
IS7915A
Other languages
Icelandic (is)
Inventor
Ramachandra Rao Dharmaraj
Narayanrao Kankan Rajendra
Original Assignee
Cipla Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9949985&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS7915(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cipla Ltd. filed Critical Cipla Ltd.
Publication of IS7915A publication Critical patent/IS7915A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A process for making (+)duloxetine or an acid addition salt thereof, comprising reacting intermediate compounds of formulae (I) and (II) so as to yield a compound of formula (III), or an acid addition salt thereof in the presence of a base and a phase transfer catalyst, where one of X and Y is hydroxy and the other is a leaving group, and subjecting a compound of formula (III), or an acid addition salt thereof, to further process steps so as to yield (+) duloxetine, or an acid addition salt thereof, substantially free of (-)duloxetine.
IS7915A 2002-12-19 2005-06-24 Process for the production of doloxetine and intermediates for use in the process IS7915A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0229583.0A GB0229583D0 (en) 2002-12-19 2002-12-19 A process for preparing duloxetine and intermediates for use therein
PCT/GB2003/005357 WO2004056795A1 (en) 2002-12-19 2003-12-10 A process for preparing duloxetine and intermediates for use therein

Publications (1)

Publication Number Publication Date
IS7915A true IS7915A (en) 2005-06-24

Family

ID=9949985

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7915A IS7915A (en) 2002-12-19 2005-06-24 Process for the production of doloxetine and intermediates for use in the process

Country Status (24)

Country Link
US (1) US7645890B2 (en)
EP (2) EP1587801B1 (en)
JP (1) JP5259048B2 (en)
KR (1) KR100926723B1 (en)
CN (2) CN100579975C (en)
AT (1) ATE353081T1 (en)
AU (2) AU2003292396B2 (en)
BR (1) BR0316902A (en)
CA (1) CA2510750A1 (en)
DE (1) DE60311599T2 (en)
ES (1) ES2279971T3 (en)
GB (1) GB0229583D0 (en)
HR (1) HRP20050657A2 (en)
IL (1) IL169232A (en)
IS (1) IS7915A (en)
MA (1) MA27706A1 (en)
MX (1) MXPA05006659A (en)
NZ (2) NZ569874A (en)
PL (1) PL377380A1 (en)
PT (1) PT1587801E (en)
RU (1) RU2351594C2 (en)
TN (1) TNSN05167A1 (en)
WO (1) WO2004056795A1 (en)
ZA (1) ZA200505656B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006027798A2 (en) * 2004-08-05 2006-03-16 Sun Pharmaceutical Industries Limited A process for preparation of an antidepressant compound
CZ297560B6 (en) * 2004-10-26 2007-02-07 Zentiva, A. S. Process for preparing (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride (duloxetine)
TWI306858B (en) * 2004-12-23 2009-03-01 Teva Pharma Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
EP1776049A2 (en) * 2005-01-27 2007-04-25 Teva Pharmaceutical Industries Ltd. Duloxetine hcl polymorphs
MX2007010931A (en) * 2005-03-08 2007-10-16 Teva Pharma Crystal forms of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2- thienyl) propanamine oxalate and the preparation thereof.
EP1858874A1 (en) * 2005-03-14 2007-11-28 Teva Pharmaceutical Industries Ltd. (s)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine-di-p-toluoyl-l-tartarate and methods of preparation thereof
US8093408B2 (en) * 2005-06-21 2012-01-10 The Company Wockhardt Antidepressant oral pharmaceutical compositions
US8153824B2 (en) * 2005-06-22 2012-04-10 The Wockhardt Company Antidepressant oral liquid compositions
US7842717B2 (en) 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
US7759500B2 (en) * 2005-12-05 2010-07-20 Teva Pharmaceutical Industries Ltd. 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
PL1971592T3 (en) * 2005-12-12 2011-09-30 Medichem Sa Improved synthesis and preparations of duloxetine salts
CZ299270B6 (en) 2006-01-04 2008-06-04 Zentiva, A. S. Process for preparing (S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride
US8362279B2 (en) * 2006-01-06 2013-01-29 Msn Laboratories Limited Process for pure duloxetine hydrochloride
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
CA2640212A1 (en) * 2006-02-13 2007-08-23 Teva Pharmaceutical Industries Ltd. A process for the preparation of (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a duloxetine intermediate
HU228458B1 (en) * 2006-03-13 2013-03-28 Egis Gyogyszergyar Nyrt Duloxetine salts for producing pharmaceutical compositions
EP1857451B1 (en) 2006-05-05 2010-07-21 Fidia Farmaceutici S.p.A. A process for the preparation of an intermediate useful for the asymmetric synthesis of (+)duloxetine
WO2007139984A2 (en) * 2006-05-23 2007-12-06 Teva Pharmaceutical Industries Ltd. Duloxetine hcl polymorphs
US20100280093A1 (en) 2006-07-03 2010-11-04 Ranbaxy Laboratories Limited Process for the preparation enantiomerically pure salts of n-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine
CZ300116B6 (en) * 2006-12-05 2009-02-11 Zentiva, A. S. Purification process of (S)-N-methyl-3-(1-naphtyloxy)-3-(2-thienyl) propylamine hydrochloride
HU227730B1 (en) 2006-12-22 2012-01-30 Richter Gedeon Nyrt Process for the preparation of duloxetine and for their the intermediates
WO2008077645A1 (en) 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
WO2008107911A2 (en) 2007-03-05 2008-09-12 Lupin Limited Novel process for preparation of duloxetine hydrochloride
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
WO2009130708A2 (en) * 2008-04-22 2009-10-29 Shodhana Laboratories Limited Preparation of duloxetine and its salts
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
ES2560459T3 (en) 2008-08-27 2016-02-19 Codexis, Inc. Cetorreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
CN103360365A (en) * 2012-04-06 2013-10-23 李晓红 New preparation process of medicinal raw material duloxetine hydrochloride of antidepressant drug
CN104230882B (en) * 2014-08-29 2017-03-08 宁波美诺华药业股份有限公司 A kind of preparation method of duloxetine hydrochloride impurity
CN104829587B (en) * 2015-05-08 2017-07-21 上海万巷制药有限公司 The preparation of duloxetine hydrochloride
CN107382958B (en) * 2017-07-05 2021-11-09 浙江华海药业股份有限公司 Crystallization method of duloxetine intermediate

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH578532A5 (en) * 1971-08-03 1976-08-13 Cassella Farbwerke Mainkur Ag
ZA817863B (en) 1980-11-14 1983-06-29 Lilly Co Eli (-)n-methyl-3-(2-methylphenoxy)-3-phenylpropylamnie,antidepressant
US4777291A (en) * 1985-02-27 1988-10-11 Eli Lilly And Company Racemization process
JPS62286959A (en) * 1986-06-05 1987-12-12 Seitetsu Kagaku Co Ltd Production of optically active cyanocarnitine salt
KR880007433A (en) * 1986-12-22 1988-08-27 메리 앤 터커 3-aryloxy-3-substituted propanamine
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
CA2042346A1 (en) * 1990-05-17 1991-11-18 Michael Alexander Staszak Chiral synthesis of 1-aryl-3-aminopropan-1-ols
JPH09176157A (en) * 1992-12-09 1997-07-08 Takeda Chem Ind Ltd Optically active aminocoumaran derivative
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
US6162949A (en) 1994-12-16 2000-12-19 Uop Llc Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
US6458955B1 (en) 1994-12-16 2002-10-01 Uop Llc Process for preparation of pharmaceutically desired enantiomers
EP0792649A1 (en) * 1996-02-29 1997-09-03 Eli Lilly And Company Treatment of sleep disorders
ID26861A (en) * 1998-05-22 2001-02-15 Lilly Co Eli JOIN THERAPY FOR TREATMENT OF DEPRESSION OF REFACTORS
DE69905938T2 (en) * 1998-11-13 2003-11-13 Eli Lilly And Co., Indianapolis COMBINATION OF DULOXETIN WITH NON-STEROID INFLAMMATORY INHIBITORS FOR THE TREATMENT OF PAIN
JP2002541235A (en) * 1999-04-09 2002-12-03 イーライ・リリー・アンド・カンパニー Method for producing 3-aryloxy-3-arylpropylamine and intermediates thereof
AU1724201A (en) * 1999-12-17 2001-06-25 Ranbaxy Laboratories Limited Process for the preparation of fluoxetine hydrochloride
EP1478641A1 (en) * 2002-01-24 2004-11-24 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine

Also Published As

Publication number Publication date
CN1747947A (en) 2006-03-15
ATE353081T1 (en) 2007-02-15
BR0316902A (en) 2005-10-25
CN101125848A (en) 2008-02-20
NZ540881A (en) 2008-09-26
NZ569874A (en) 2009-11-27
MXPA05006659A (en) 2006-02-22
TNSN05167A1 (en) 2007-05-14
WO2004056795A8 (en) 2005-08-11
WO2004056795A1 (en) 2004-07-08
EP1690861B1 (en) 2012-09-12
ZA200505656B (en) 2006-04-26
RU2351594C2 (en) 2009-04-10
EP1587801B1 (en) 2007-01-31
PT1587801E (en) 2007-04-30
US20060205956A1 (en) 2006-09-14
AU2003292396B2 (en) 2010-05-20
JP2006514030A (en) 2006-04-27
KR100926723B1 (en) 2009-11-16
CN100579975C (en) 2010-01-13
US7645890B2 (en) 2010-01-12
MA27706A1 (en) 2006-01-02
IL169232A (en) 2010-02-17
ES2279971T3 (en) 2007-09-01
KR20050089839A (en) 2005-09-08
DE60311599T2 (en) 2007-10-25
CN101125848B (en) 2012-09-12
AU2010200142B2 (en) 2012-04-12
PL377380A1 (en) 2006-02-06
EP1690861A3 (en) 2006-09-06
RU2005122662A (en) 2006-01-20
HRP20050657A2 (en) 2005-10-31
EP1690861A2 (en) 2006-08-16
AU2003292396A1 (en) 2004-07-14
EP1587801A1 (en) 2005-10-26
DE60311599D1 (en) 2007-03-22
AU2010200142A1 (en) 2010-02-04
JP5259048B2 (en) 2013-08-07
GB0229583D0 (en) 2003-01-22
CA2510750A1 (en) 2004-07-08

Similar Documents

Publication Publication Date Title
GB0229583D0 (en) A process for preparing duloxetine and intermediates for use therein
WO2006004100A8 (en) Method for producing 1,2-dihydropyridine-2-one compound
PL1781683T3 (en) Process for the preparation of 17-vinyl- triflates as intermediates
NZ598172A (en) Synthesis of boronic ester and acid compounds
IL175024A0 (en) Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl-pyrazole-4-carboxylic acid esters
TNSN05111A1 (en) Process for the preparation of (s,s) -cis -2- benzhydryl -3- benzylaminoquinuclidine
TW200726754A (en) Chemical process
MXPA03005429A (en) Method for producing sulfonamide-substituted imidazotriazinones.
EA200701470A1 (en) METHODS OF OBTAINING DERIVATIVES OF 4- (FENOXY-5-METHYLPYRIMIDIN-4-ILOXI) PIPERIDIN-1-CARBIC ACID AND RELATED COMPOUNDS
NO20080812L (en) Process for Preparation of 4 β-Amino-4'-demethyl-4-4-deoxy podophyllotoxin
EA200200719A1 (en) METHOD OF OBTAINING CYTALOPRAMA
BR0308345A (en) Process for trans-4-amino-1-cyclohexanecarboxylic acid derivatives
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
DE60102008D1 (en) PRODUCTION PROCESS FOR A KNOWN TERAZOLE DERIVATIVE
ZA200206443B (en) Method for the production of spirocyclic tetronic acid derivatives.
EA200000924A3 (en) Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof
EP1215206A4 (en) Processes for the preparation of 4(5)-amino-5(4)-carboxamidoimidazoles and intermediates thereof
EE05136B1 (en) Method for the preparation of substituted imidazopidine compounds
RU2003122994A (en) COMPLEX COMPOUND OF 6-METHYLURACYL WITH AMBERIC ACID, MANIFESTING ANTI-HYPOXIC ACTIVITY AND METHOD FOR ITS PRODUCTION
ATE489385T1 (en) METHOD FOR PRODUCING IMIDAZOPYRIDINES
AU2003238382A1 (en) Method for producing specific crystalline modifications of polymorphous substances
NO20055991L (en) Process for Synthesizing Heterocyclic Compounds
EP0658542A4 (en) PROCESS FOR PRODUCING -g (a) -HYDROXYIMINOPHENYLACETONITRILE.
NO20055755L (en) New intermediate for the preparation of therapeutically active imidazopyridines
EP1219610A4 (en) Process for the preparation of oxazole derivatives