IT1059516B - Procedimento per la preparazione di beta-ergocriptina - Google Patents

Procedimento per la preparazione di beta-ergocriptina

Info

Publication number: IT1059516B
Authority: IT; Italy
Prior art keywords: ergocryptine; beta; nitrogen; carbon; cultivation
Prior art date: 1974-06-07

Application number

IT2374274A

Other languages

English (en)

Inventor

M Bianchi

A Minghetti

C Spalla

Original Assignee

Farmaceutici Italia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-07

Filing date

1974-06-07

Publication date

1982-06-21

1974-06-07 Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia

1974-06-07 Priority to IT2374274A priority Critical patent/IT1059516B/it

1975-01-30 Priority to BE152881A priority patent/BE824987A/fr

1982-06-21 Application granted granted Critical

1982-06-21 Publication of IT1059516B publication Critical patent/IT1059516B/it

Links

IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title abstract 3
229950010031 beta-ergocryptine Drugs 0.000 title abstract 3
YYWXOXLDOMRDHW-UHFFFAOYSA-N beta-ergocryptine Natural products C1=CC(C=2C(N(C)CC(C=2)C(=O)NC2(C(=O)N3C(C(N4CCCC4C3(O)O2)=O)C(C)CC)C(C)C)C2)=C3C2=CNC3=C1 YYWXOXLDOMRDHW-UHFFFAOYSA-N 0.000 title abstract 3
229910052799 carbon Inorganic materials 0.000 title abstract 3
229910052757 nitrogen Inorganic materials 0.000 title abstract 3
YYWXOXLDOMRDHW-SGVWFJRMSA-N β-ergocryptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)[C@@H](C)CC)C(C)C)C2)=C3C2=CNC3=C1 YYWXOXLDOMRDHW-SGVWFJRMSA-N 0.000 title abstract 3
241000221751 Claviceps purpurea Species 0.000 title abstract 2
229910052500 inorganic mineral Inorganic materials 0.000 title abstract 2
239000011707 mineral Substances 0.000 title abstract 2
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
229930195725 Mannitol Natural products 0.000 abstract 1
239000001888 Peptone Substances 0.000 abstract 1
108010080698 Peptones Proteins 0.000 abstract 1
229930013930 alkaloid Natural products 0.000 abstract 1
150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
YDOTUXAWKBPQJW-UHFFFAOYSA-N alpha-Ergocryptinine Natural products C1=CC(C=2C(N(C)CC(C=2)C(=O)NC2(C(=O)N3C(C(N4CCCC4C3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=CNC3=C1 YDOTUXAWKBPQJW-UHFFFAOYSA-N 0.000 abstract 1
229950001817 alpha-ergocryptine Drugs 0.000 abstract 1
YDOTUXAWKBPQJW-NSLWYYNWSA-N alpha-ergocryptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=CNC3=C1 YDOTUXAWKBPQJW-NSLWYYNWSA-N 0.000 abstract 1
235000019270 ammonium chloride Nutrition 0.000 abstract 1
150000003863 ammonium salts Chemical class 0.000 abstract 1
229960001230 asparagine Drugs 0.000 abstract 1
235000009582 asparagine Nutrition 0.000 abstract 1
239000005018 casein Substances 0.000 abstract 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
235000021240 caseins Nutrition 0.000 abstract 1
235000015165 citric acid Nutrition 0.000 abstract 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
235000011187 glycerol Nutrition 0.000 abstract 1
239000001963 growth medium Substances 0.000 abstract 1
239000000594 mannitol Substances 0.000 abstract 1
235000010355 mannitol Nutrition 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
235000019319 peptone Nutrition 0.000 abstract 1
229940066779 peptones Drugs 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000600 sorbitol Substances 0.000 abstract 1
235000010356 sorbitol Nutrition 0.000 abstract 1
239000001384 succinic acid Substances 0.000 abstract 1
235000011044 succinic acid Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IT2374274A 1974-06-07 1974-06-07 Procedimento per la preparazione di beta-ergocriptina IT1059516B (it)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IT2374274A IT1059516B (it)	1974-06-07	1974-06-07	Procedimento per la preparazione di beta-ergocriptina
BE152881A BE824987A (fr)	1974-06-07	1975-01-30	Procede pour la preparation de la beta-ergocriptine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2374274A IT1059516B (it)	1974-06-07	1974-06-07	Procedimento per la preparazione di beta-ergocriptina

Publications (1)

Publication Number	Publication Date
IT1059516B true IT1059516B (it)	1982-06-21

Family

ID=11209593

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2374274A IT1059516B (it)	1974-06-07	1974-06-07	Procedimento per la preparazione di beta-ergocriptina

Country Status (2)

Country	Link
BE (1)	BE824987A (it)
IT (1)	IT1059516B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU178405B (en) *	1980-02-08	1982-04-28	Richter Gedeon Vegyeszet	Process for preparing ergocornine and beta-ergocryptine by fermentation
CS222391B1 (en) *	1981-07-28	1983-06-24	Karin Strnadova	Microorganism strain of the claviceps purpurea /fr./ tul,ccm f-725 species
CN101238208A (zh) *	2005-11-07	2008-08-06	伊瓦克斯制药有限公司	真菌麦角菌（Fr.)Tul.的工业生产菌株

1974
- 1974-06-07 IT IT2374274A patent/IT1059516B/it active
1975
- 1975-01-30 BE BE152881A patent/BE824987A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE824987A (fr)	1975-05-15

Publication	Publication Date	Title
ES407544A1 (es)	1975-11-01	Mejoras en un metodo de produccion de pululano.
GB1358962A (en)	1974-07-03	Fermentation process for the production of erythritol
GB1387965A (en)	1975-03-19	Process for the production of the antibiotic cephemycin
ES412128A1 (es)	1976-05-01	Un procedimiento de produccion de sustancias antibioticas policarbociclicas nitrogenadas.
ES395935A1 (es)	1974-10-01	Un procedimiento para la produccion del antibiotico de ws- 4.545.
ES422433A1 (es)	1977-03-01	Un procedimiento para la produccion del antibiotico a-287.
GB1419668A (en)	1975-12-31	Microbiological fermentation process
ES382658A1 (es)	1972-11-01	Procedimiento de produccion de un nuevo antibiotico.
ES409978A1 (es)	1976-07-01	Metodo para la produccion de antibioticos no nitrogenados acidos.
US3799841A (en)	1974-03-26	Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates
BG44030A3 (en)	1988-09-15	Method for preparing of antibiotic a80190
GB1394849A (en)	1975-05-21	5-dihydrocoriolin c and process for producing the same
BG40969A3 (bg)	1987-03-14	Метод за получаване на антибиотика сизомицин
ES422625A1 (es)	1976-09-01	Un procedimiento para la produccion de bicilomicina.
ES405289A1 (es)	1975-07-01	Procedimiento de produccion de una sustancia inhibidora deldesarrollo de hongos.
GB1300364A (en)	1972-12-20	Cellulase production
IE41079B1 (en)	1979-10-10	Antibiotic a-28086 and process for production thereof
ES415056A1 (es)	1976-02-16	Procedimiento de produccion de rifamicina b.
GB925282A (en)	1963-05-08	Fermentation process for the production of demethyltetracycline
GB1480684A (en)	1977-07-20	Process for producing bacterial cells
GB826097A (en)	1959-12-23	Process for producing úý-glutamic acid by fermentation
GB1408158A (en)	1975-10-01	Microbial beta-amylase and preparation thereof
GB1377339A (en)	1974-12-11	Method for producing deacetoxycephalosporin c
ES419574A1 (es)	1976-04-01	Procedimiento para la produccion de agentes antibacteria- nos.
ES406202A1 (es)	1975-07-01	Un procedimiento para la produccion de una sustancia anti- biotica.