IT1108727B - Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments - Google Patents

Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments

Info

Publication number
IT1108727B
IT1108727B IT2482578A IT2482578A IT1108727B IT 1108727 B IT1108727 B IT 1108727B IT 2482578 A IT2482578 A IT 2482578A IT 2482578 A IT2482578 A IT 2482578A IT 1108727 B IT1108727 B IT 1108727B
Authority
IT
Italy
Prior art keywords
chromone
substd
opt
alkyl
derivs
Prior art date
Application number
IT2482578A
Other languages
Italian (it)
Other versions
IT7824825A0 (en
Inventor
Gianfederico Doria
Romeo Ciriavo
Maria Luisa Corno
Francesco Lauria
Piero Sberze
Marcellino Tibolla
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT1078072A priority Critical patent/AT326181B/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IT7824825A0 publication Critical patent/IT7824825A0/en
Priority to IT2482578A priority patent/IT1108727B/en
Priority to US05/921,853 priority patent/US4160028A/en
Priority to IL55139A priority patent/IL55139A/en
Priority to NL787807636A priority patent/NL7807636A/en
Priority to DE19782832358 priority patent/DE2832358A1/en
Priority to NZ187965A priority patent/NZ187965A/en
Priority to DK332178A priority patent/DK156724C/en
Priority to GB7831206A priority patent/GB2002367B/en
Priority to GR56892A priority patent/GR73175B/el
Priority to YU1842/78A priority patent/YU42089B/en
Priority to SE7808294A priority patent/SE443785B/en
Priority to CA308,526A priority patent/CA1115273A/en
Priority to FI782368A priority patent/FI72516C/en
Priority to NO782636A priority patent/NO150606C/en
Priority to HU78EA186A priority patent/HU180736B/en
Priority to FR7822872A priority patent/FR2399424A1/en
Priority to CH825478A priority patent/CH636355A5/en
Priority to JP53094468A priority patent/JPS5924988B2/en
Priority to AT0561878A priority patent/AT363931B/en
Priority to AT303380A priority patent/AT363471B/en
Priority to KE321482A priority patent/KE3214A/en
Priority to MY39/83A priority patent/MY8300039A/en
Priority to HK594/84A priority patent/HK59484A/en
Application granted granted Critical
Publication of IT1108727B publication Critical patent/IT1108727B/en

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Abstract

Chromone derivs. of formula (I) and their salts are new: In the formula, n=0 or 1; R1 is H or 1-20C alkyl opt. substd. by 2-5C alkanoyloxy or NR4R5; R4 and R5 are H or 1-10C alkyl, or NR4R5 is pyrrolidino, piperidino or morpholino; R2 is 1-8C alkyl or 3-4C alkenyl; R3 is an opt. Me-substd. furyl, thienyl or pyridyl gp., or a phenyl gp. opt. mono- or di-substd. by halogen and/or (O)mR8; m=0 or 1; R8 is 1-6C alkyl or 3-4C alkenyl opt. substd. by OH or 1-2C alkoxy. Cpds. (I) are anti-allergic agents, some with higher activity than Na cromoglycate. Cpds. (I) also have antiulcer and bronchodilatory activity. A typical cpd. (I) is trans-6-carboxy-3-propyl-2-(2-phenylcyclopropyl)-chromone. In an example, this is prepd. from methyl 3-valeroyl-4-hydroxybenzoate and trans-2-phenylcyclopropyl-1-carbonyl chloride.
IT2482578A 1970-06-15 1978-06-22 Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments IT1108727B (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
AT1078072A AT326181B (en) 1970-06-15 1971-04-27 LOCKABLE PIPE COUPLING ON AN AUTOMATIC CENTRAL BUFFER COUPLING OF RAIL VEHICLES
IT2482578A IT1108727B (en) 1978-06-22 1978-06-22 Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments
US05/921,853 US4160028A (en) 1977-08-02 1978-07-03 Substituted 2-cyclopropyl-chromones and pharmaceutical compositions and use thereof
IL55139A IL55139A (en) 1977-08-02 1978-07-13 Substituted 2-cyclopropyl-chromones,process for their preparation and pharmaceutical compositions containing them
NL787807636A NL7807636A (en) 1977-08-02 1978-07-17 SUBSTITUTED 2-CYCLOPROPYL CHROMONES.
DE19782832358 DE2832358A1 (en) 1977-08-02 1978-07-22 SUBSTITUTED 2-CYCLOPROPYL CHROMONES, THE METHOD OF MANUFACTURING THEM AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM
NZ187965A NZ187965A (en) 1977-08-02 1978-07-26 2-cyclopropylchromone derivatives and pharmaceutical compositions
DK332178A DK156724C (en) 1977-08-02 1978-07-26 ANALOGY PROCEDURE FOR THE PREPARATION OF CYCLOPROPYL CHROMONE DERIVATIVES
GB7831206A GB2002367B (en) 1977-08-02 1978-07-26 Substituted 2-cyclopropyl-chromones
GR56892A GR73175B (en) 1977-08-02 1978-07-29
YU1842/78A YU42089B (en) 1977-08-02 1978-07-31 Process for obtaining substituted 2-cyclopropyl-chromones
CA308,526A CA1115273A (en) 1977-08-02 1978-08-01 Substituted 2-cyclopropyl-chromones and process for their preparation
SE7808294A SE443785B (en) 1977-08-02 1978-08-01 SUBSTITUTED 2-CYCLOPROPYL CHROMONES
FI782368A FI72516C (en) 1977-08-02 1978-08-01 Process for the preparation of pharmaceutically active 3,6-disubstituting the 2-cyclopropyl chromones.
NO782636A NO150606C (en) 1977-08-02 1978-08-01 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE SUBSTITUTED CHROMONS
HU78EA186A HU180736B (en) 1977-08-02 1978-08-01 Process for preparing substituted derivatives of 2-cyclopropyl-chromone derivatives
JP53094468A JPS5924988B2 (en) 1977-08-02 1978-08-02 Substituted 2↓-cyclopropyl↓-chromone, its production method and pharmaceutical compositions having antiallergic activity
CH825478A CH636355A5 (en) 1977-08-02 1978-08-02 SUBSTITUTED 2-CYCLOPROPYL CHROMONE.
FR7822872A FR2399424A1 (en) 1977-08-02 1978-08-02 SUBSTITUTE 2-CYCLOPROPYL-CHROMONES, THEIR PREPARATION PROCESS, AND THEIR USE AS ANTIALLERGICS
AT0561878A AT363931B (en) 1977-08-02 1978-08-02 METHOD FOR PRODUCING NEW SUBSTITUTED 2-CYCLOPROPYL CHROMONES, THEIR SALTS AND ISOMERS
AT303380A AT363471B (en) 1977-08-02 1980-06-09 METHOD FOR PRODUCING NEW SUBSTITUTED 2-CYCLOPROPYL CHROMONES, THEIR SALTS AND ISOMERS
KE321482A KE3214A (en) 1975-05-08 1982-05-21 Substituted 2-cyclopropyl-chromones cis-bicyclooctyl-alkyl-amine derivatives
MY39/83A MY8300039A (en) 1977-08-02 1983-12-30 Substituted 2-cyclopropyl-chromones
HK594/84A HK59484A (en) 1977-08-02 1984-08-02 Substituted 2-cyclopropyl-chromones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2482578A IT1108727B (en) 1978-06-22 1978-06-22 Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments

Publications (2)

Publication Number Publication Date
IT7824825A0 IT7824825A0 (en) 1978-06-22
IT1108727B true IT1108727B (en) 1985-12-09

Family

ID=11214847

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2482578A IT1108727B (en) 1970-06-15 1978-06-22 Antiallergic 6-carboxy-2-cyclopropyl-chromone derivs. - also useful in antiulcer and bronchodilator medicaments

Country Status (1)

Country Link
IT (1) IT1108727B (en)

Also Published As

Publication number Publication date
IT7824825A0 (en) 1978-06-22

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