IT1111676B - 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants - Google Patents

1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants

Info

Publication number
IT1111676B
IT1111676B IT1945078A IT1945078A IT1111676B IT 1111676 B IT1111676 B IT 1111676B IT 1945078 A IT1945078 A IT 1945078A IT 1945078 A IT1945078 A IT 1945078A IT 1111676 B IT1111676 B IT 1111676B
Authority
IT
Italy
Prior art keywords
substd
opt
alkyl
derivs
aryl
Prior art date
Application number
IT1945078A
Other languages
Italian (it)
Other versions
IT7819450A0 (en
Inventor
Piero Melloni
Torre Arturo Della
Giovanni Claudio Carniel
Alessandro Rossi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IT7819450A0 publication Critical patent/IT7819450A0/en
Priority to IT1945078A priority Critical patent/IT1111676B/en
Priority to IL56369A priority patent/IL56369A/en
Priority to US06/001,604 priority patent/US4229449A/en
Priority to GB7901130A priority patent/GB2014981B/en
Priority to CY1172A priority patent/CY1172A/en
Priority to AU43327/79A priority patent/AU525954B2/en
Priority to DE1998175005 priority patent/DE19875005I2/en
Priority to DE2901032A priority patent/DE2901032C2/en
Priority to NZ189418A priority patent/NZ189418A/en
Priority to YU96/79A priority patent/YU42094B/en
Priority to SI7910096A priority patent/SI7910096A8/en
Priority to NL7900412A priority patent/NL190327C/en
Priority to DK022679A priority patent/DK156565C/en
Priority to FR7901413A priority patent/FR2442839A1/en
Priority to SE7900498A priority patent/SE446727B/en
Priority to CH582/79A priority patent/CH650245A5/en
Priority to AT0040679A priority patent/AT371813B/en
Priority to CS905179A priority patent/CS207697B2/en
Priority to FI790177A priority patent/FI71135C/en
Priority to NO790205A priority patent/NO146953C/en
Priority to CA319,931A priority patent/CA1128942A/en
Priority to JP449479A priority patent/JPS54148739A/en
Priority to IE107/79A priority patent/IE47727B1/en
Priority to FR7922678A priority patent/FR2430412B1/en
Priority to SU802897011A priority patent/SU980617A3/en
Priority to US06/161,509 priority patent/US4271160A/en
Priority to AT0419781A priority patent/AT376964B/en
Priority to KE3243A priority patent/KE3243A/en
Priority to HK57/83A priority patent/HK5783A/en
Priority to MY8418A priority patent/MY8400018A/en
Application granted granted Critical
Publication of IT1111676B publication Critical patent/IT1111676B/en
Priority to CS914133A priority patent/CS413391A3/en
Priority to MX9203112A priority patent/MX9203112A/en
Priority to BG098513A priority patent/BG61056B2/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Propanolamine derivs. of formula (I) and their pharmaceutically acceptable salts are new: (n and n1 = 1-3; R and R1 are each same or different H, halo, 1-6C haloalkyl, OH, 1-6C alkoxy or opt. substd. alkyl, aryl(1-6C)-alkyl or aryl(1-6C)alkoxy (both opt. substd.), NO2, NR5R6, or two adjacent gps. are together OCH2O; R2 = H, opt. substd. 1-12C alkyl or aryl(1-6C)alkyl; R3 and R4 = H, 1-6C opt. substd. alkyl, 2-4C alkenyl or alkynyl, aryl(1-4C)alkyl (opt. substd.), 3-7C cycloalkyl (opt. substd.) or R3 + R4 complete a monocyclic 5 or 6 member heterocycle which may be unsatd. or satd. opt. substd. and or contain further O, S or N atoms; R2 and R4 may also together be CH2CH2; R5 and R6 = H or 1-6C alkyl).
IT1945078A 1978-01-20 1978-01-20 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants IT1111676B (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
IT1945078A IT1111676B (en) 1978-01-20 1978-01-20 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants
IL56369A IL56369A (en) 1978-01-20 1979-01-04 Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US06/001,604 US4229449A (en) 1978-01-20 1979-01-08 Substituted morpholine derivatives and compositions
GB7901130A GB2014981B (en) 1978-01-20 1979-01-11 Substituted propanolamine and morpholine derivatives
CY1172A CY1172A (en) 1978-01-20 1979-01-11 Substituted propanolamine and morpholine derivatives
AU43327/79A AU525954B2 (en) 1978-01-20 1979-01-12 Substituted propanolamine and morpholine derivatives
DE1998175005 DE19875005I2 (en) 1978-01-20 1979-01-12 Substituted morpholine derivatives and their use
DE2901032A DE2901032C2 (en) 1978-01-20 1979-01-12 Substituted morpholine derivatives and their use
NZ189418A NZ189418A (en) 1978-01-20 1979-01-17 Propanolamine and morpholine derivatives pharmaceutical compositions
YU96/79A YU42094B (en) 1978-01-20 1979-01-17 Process for obtaining new morpnoline compounds
SI7910096A SI7910096A8 (en) 1978-01-20 1979-01-17 Process for preparing novel morpholine compounds
NL7900412A NL190327C (en) 1978-01-20 1979-01-18 SUBSTITUTED 2- (PHENOXYMETHYL) MORPHOLINE DERIVATIVE WITH ANTI-DEPRESSIVE ACTION, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL PREPARATION CONTAINING SUCH A MORPHOLINE DERIVATIVE.
DK022679A DK156565C (en) 1978-01-20 1979-01-18 ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED MORPHOLINE DERIVATIVES
AT0040679A AT371813B (en) 1978-01-20 1979-01-19 METHOD FOR PRODUCING NEW SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES AND THEIR ISOMERS AND SALTS
SE7900498A SE446727B (en) 1978-01-20 1979-01-19 SUBSTITUTED MORPHOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF
CH582/79A CH650245A5 (en) 1978-01-20 1979-01-19 SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
FR7901413A FR2442839A1 (en) 1978-01-20 1979-01-19 SUBSTITUTED MORPHOLINE DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESS FOR THEIR PREPARATION
CS905179A CS207697B2 (en) 1978-01-20 1979-01-19 Method of makingthe substituted propanolamine and morpholine derivatives
FI790177A FI71135C (en) 1978-01-20 1979-01-19 FRUIT PROCESSING OF PHARMACOLOGICAL ACTIVE SUBSTITUTES MORPHOLINDERIVAT
NO790205A NO146953C (en) 1978-01-20 1979-01-19 ANALOGY PROCEDURE FOR THE PREPARATION OF SUBSTITUTED PROPANOLAMINE AND MORPHOLINE DERIVATIVES
CA319,931A CA1128942A (en) 1978-01-20 1979-01-19 Substituted propanolamine and morpholine derivatives and process for their preparation
JP449479A JPS54148739A (en) 1978-01-20 1979-01-20 Substituted propanolamine and morpholine derivative
IE107/79A IE47727B1 (en) 1978-01-20 1979-01-30 Substituted propanolamine and morpholine derivatives
FR7922678A FR2430412B1 (en) 1978-01-20 1979-09-11 SUBSTITUTED PROPANOLAMINE DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESS FOR THEIR PREPARATION
SU802897011A SU980617A3 (en) 1978-01-20 1980-03-20 Process for producing morpholine derivatives or their acid-additive salts in the form of optical isomers or mixture of optical isomers
US06/161,509 US4271160A (en) 1978-01-20 1980-06-20 Substituted morpholine derivatives and pharmaceutical compositions
AT0419781A AT376964B (en) 1978-01-20 1981-09-30 METHOD FOR PRODUCING NEW SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR ISOMERS AND SALTS
KE3243A KE3243A (en) 1978-01-20 1982-10-25 Substituted propanolamine and morpholine derivatives
HK57/83A HK5783A (en) 1978-01-20 1983-02-08 Substituted propanolamine and morpholine derivatives
MY8418A MY8400018A (en) 1978-01-20 1984-12-31 Substituted propanolamine and morpholine derivatives
CS914133A CS413391A3 (en) 1978-01-20 1991-12-30 Substituted propanolamine and morpholine derivatives
MX9203112A MX9203112A (en) 1978-01-20 1992-06-22 DERIVATIVES OF 2-PHENOXY-METHYL-MORPHOLINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
BG098513A BG61056B2 (en) 1978-01-20 1994-02-22 Substituted propanolamine and morpholine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1945078A IT1111676B (en) 1978-01-20 1978-01-20 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants

Publications (2)

Publication Number Publication Date
IT7819450A0 IT7819450A0 (en) 1978-01-20
IT1111676B true IT1111676B (en) 1986-01-13

Family

ID=11158109

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1945078A IT1111676B (en) 1978-01-20 1978-01-20 1-amino-2-hydroxy-3-phenoxy-3-phenyl-propane derivs. - useful as antidepressants

Country Status (2)

Country Link
IT (1) IT1111676B (en)
MX (1) MX9203112A (en)

Also Published As

Publication number Publication date
IT7819450A0 (en) 1978-01-20
MX9203112A (en) 1992-07-01

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Legal Events

Date Code Title Description
MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 599, 19971128; PHARMACIA UPJOHN SPA

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970124