IT1163772B - Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche - Google Patents
Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceuticheInfo
- Publication number
- IT1163772B IT1163772B IT22045/83A IT2204583A IT1163772B IT 1163772 B IT1163772 B IT 1163772B IT 22045/83 A IT22045/83 A IT 22045/83A IT 2204583 A IT2204583 A IT 2204583A IT 1163772 B IT1163772 B IT 1163772B
- Authority
- IT
- Italy
- Prior art keywords
- effect
- oligosaccharides
- alpha
- hydosanes
- mucopolysaccharides
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 210000004877 mucosa Anatomy 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 230000002429 anti-coagulating effect Effects 0.000 abstract 1
- 238000013375 chromatographic separation Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22045/83A IT1163772B (it) | 1983-07-13 | 1983-07-13 | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
| EP84108229A EP0134502B1 (en) | 1983-07-13 | 1984-07-12 | Heparan sulfate fractions, process for their preparation and compositions thereof |
| AU30538/84A AU577300B2 (en) | 1983-07-13 | 1984-07-12 | Heterogeneous oligosaccharides |
| AT84108229T ATE59656T1 (de) | 1983-07-13 | 1984-07-12 | Heparansulfat-fraktionen, ihre herstellung sowie sie enthaltende mittel. |
| DE8484108229T DE3483801D1 (de) | 1983-07-13 | 1984-07-12 | Heparansulfat-fraktionen, ihre herstellung sowie sie enthaltende mittel. |
| JP59144524A JPS6038390A (ja) | 1983-07-13 | 1984-07-13 | ヘパラン硫酸塩分画、それを得る方法および製薬学的組成物 |
| ZA845434A ZA845434B (en) | 1983-07-13 | 1984-07-13 | Complexable heterogeneous oligosaccharides and alpha-hydosanes having therapeutical activity,process for their preparation and related pharmaceutical compositions |
| CA000458868A CA1277937C (en) | 1983-07-13 | 1984-07-13 | Complexable heterogeneous oligosaccharides and alpha-hydosanes having therapeuticaltivity, process for thier preparation and related pharmaceutical compositions |
| US07/554,972 US5470965A (en) | 1983-07-13 | 1990-07-17 | Complexable heterogenous oligosaccharides and alpha-hydosanes having therapeutical activity, process for their preparation and related pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22045/83A IT1163772B (it) | 1983-07-13 | 1983-07-13 | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT8322045A0 IT8322045A0 (it) | 1983-07-13 |
| IT8322045A1 IT8322045A1 (it) | 1985-01-13 |
| IT1163772B true IT1163772B (it) | 1987-04-08 |
Family
ID=11190660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT22045/83A IT1163772B (it) | 1983-07-13 | 1983-07-13 | Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5470965A (it) |
| EP (1) | EP0134502B1 (it) |
| JP (1) | JPS6038390A (it) |
| AT (1) | ATE59656T1 (it) |
| AU (1) | AU577300B2 (it) |
| CA (1) | CA1277937C (it) |
| DE (1) | DE3483801D1 (it) |
| IT (1) | IT1163772B (it) |
| ZA (1) | ZA845434B (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1208509B (it) * | 1985-03-13 | 1989-07-10 | Mediolanum Farmaceutici Srl | Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico. |
| US4847338A (en) * | 1985-03-28 | 1989-07-11 | University Of Iowa Research Foundation | Low molecular weight heparin fragments as inhibitors of complement activation |
| AU7742591A (en) * | 1990-04-06 | 1991-10-30 | Washington University | Anticoagulant oligosaccharides |
| US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3908004A (en) * | 1970-05-20 | 1975-09-23 | C L Basingstoke Limited | Process for making injectable iron compositions for treating iron-deficiency anemia |
| IT1083903B (it) * | 1977-08-09 | 1985-05-25 | Lobo Srl | Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche |
| SE449753B (sv) * | 1978-11-06 | 1987-05-18 | Choay Sa | Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav |
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
| FR2535324A1 (fr) * | 1982-10-27 | 1984-05-04 | Choay Sa | Station perfectionnee pour l'epuration d'eaux usees |
| IT1189298B (it) * | 1982-06-18 | 1988-02-04 | Manetti & Roberts Italo Brit | Procedimento per produrre i glicosa minoglicani dermatansolfato ed eparan-solfato sostanzialmente puri e loro impiego farmaceutico |
| FR2538404B1 (it) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
| IT1195497B (it) * | 1983-03-08 | 1988-10-19 | Opocrin Spa | Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina |
-
1983
- 1983-07-13 IT IT22045/83A patent/IT1163772B/it active
-
1984
- 1984-07-12 AT AT84108229T patent/ATE59656T1/de not_active IP Right Cessation
- 1984-07-12 DE DE8484108229T patent/DE3483801D1/de not_active Expired - Fee Related
- 1984-07-12 EP EP84108229A patent/EP0134502B1/en not_active Expired - Lifetime
- 1984-07-12 AU AU30538/84A patent/AU577300B2/en not_active Ceased
- 1984-07-13 CA CA000458868A patent/CA1277937C/en not_active Expired - Fee Related
- 1984-07-13 ZA ZA845434A patent/ZA845434B/xx unknown
- 1984-07-13 JP JP59144524A patent/JPS6038390A/ja active Granted
-
1990
- 1990-07-17 US US07/554,972 patent/US5470965A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0134502B1 (en) | 1991-01-02 |
| AU3053884A (en) | 1985-01-17 |
| ATE59656T1 (de) | 1991-01-15 |
| EP0134502A1 (en) | 1985-03-20 |
| CA1277937C (en) | 1990-12-18 |
| US5470965A (en) | 1995-11-28 |
| ZA845434B (en) | 1985-02-27 |
| IT8322045A1 (it) | 1985-01-13 |
| JPH0446281B2 (it) | 1992-07-29 |
| AU577300B2 (en) | 1988-09-22 |
| IT8322045A0 (it) | 1983-07-13 |
| DE3483801D1 (de) | 1991-02-07 |
| JPS6038390A (ja) | 1985-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970730 |