IT1167038B - Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina - Google Patents

Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina

Info

Publication number: IT1167038B
Authority: IT; Italy
Prior art keywords: deoxycholic acid; prodn; taurourso; urso; deriv
Prior art date: 1983-11-30

Application number

IT23951/83A

Other languages

English (en)

Other versions

IT8323951A0 (it

Inventor

Massimo Parenti

Original Assignee

Prodotti Chimici & Alimentari

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-30

Filing date

1983-11-30

Publication date

1987-05-06

1983-11-30 Application filed by Prodotti Chimici & Alimentari filed Critical Prodotti Chimici & Alimentari

1983-11-30 Priority to IT23951/83A priority Critical patent/IT1167038B/it

1983-11-30 Publication of IT8323951A0 publication Critical patent/IT8323951A0/it

1984-11-16 Priority to BE0/214015A priority patent/BE901069A/fr

1987-05-06 Application granted granted Critical

1987-05-06 Publication of IT1167038B publication Critical patent/IT1167038B/it

Links

RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 title abstract 3
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 2
BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 title abstract 2
BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 title abstract 2
229960001661 ursodiol Drugs 0.000 title abstract 2
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 abstract 2
IRFSXVIRXMYULF-UHFFFAOYSA-N 1,2-dihydroquinoline Chemical compound C1=CC=C2C=CCNC2=C1 IRFSXVIRXMYULF-UHFFFAOYSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
239000007822 coupling agent Substances 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
-1 isobutylisobutoxycarbonyl Chemical group 0.000 abstract 1
229960003080 taurine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

IT23951/83A 1983-11-30 1983-11-30 Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina IT1167038B (it)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IT23951/83A IT1167038B (it)	1983-11-30	1983-11-30	Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina
BE0/214015A BE901069A (fr)	1983-11-30	1984-11-16	Procede de synthese d'acide ursodesoxycholique conjugue avec la taurine et produit ainsi obtenu.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23951/83A IT1167038B (it)	1983-11-30	1983-11-30	Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina

Publications (2)

Publication Number	Publication Date
IT8323951A0 IT8323951A0 (it)	1983-11-30
IT1167038B true IT1167038B (it)	1987-05-06

Family

ID=11211090

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT23951/83A IT1167038B (it)	1983-11-30	1983-11-30	Procedimento per la sintesi di acido ursodesossicolico coniugato con la taurina

Country Status (2)

Country	Link
BE (1)	BE901069A (it)
IT (1)	IT1167038B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH674369A5 (it) *	1986-11-26	1990-05-31	Jago Res Ag
IT1219733B (it) *	1988-06-28	1990-05-24	Istituto Chemioterapico Di Lod	Derivato dell' acido ursodesossicolico
IT1230796B (it) *	1989-05-30	1991-10-29	Prodotti Chimici Alimentari	Procedimento per la preparazione di acido tauroursodesossicolico biidrato.
EP1985622A1 (en) *	2007-04-23	2008-10-29	Prodotti Chimici E Alimentari Spa	Process for the preparation of tauroursodesoxycholic acid

1983
- 1983-11-30 IT IT23951/83A patent/IT1167038B/it active Protection Beyond IP Right Term
1984
- 1984-11-16 BE BE0/214015A patent/BE901069A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
BE901069A (fr)	1985-03-15
IT8323951A0 (it)	1983-11-30

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Legal Events

Date	Code	Title	Description
1992-05-13	ITCP	Complementary protection certificate	Free format text: CCP 292
1992-12-01	MEDD	Supplementary protection certificate for pharmaceutical products: granted	Free format text: CCP 292, 19920513; PRODOTTI CHIMICI E ALIMENTARI SPA
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971127