IT1207507B - Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. - Google Patents

Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Info

Publication number
IT1207507B
IT1207507B IT8522559A IT2255985A IT1207507B IT 1207507 B IT1207507 B IT 1207507B IT 8522559 A IT8522559 A IT 8522559A IT 2255985 A IT2255985 A IT 2255985A IT 1207507 B IT1207507 B IT 1207507B
Authority
IT
Italy
Prior art keywords
hydroxyethoxymethyl
guanine
conjugate
human albumin
preparation
Prior art date
Application number
IT8522559A
Other languages
English (en)
Other versions
IT8522559A0 (it
Inventor
Massimo Balducci
Luigi Fiume
Corrado Busi
Alessandro Mattioli
Original Assignee
Baldacci Lab Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baldacci Lab Spa filed Critical Baldacci Lab Spa
Priority to IT8522559A priority Critical patent/IT1207507B/it
Publication of IT8522559A0 publication Critical patent/IT8522559A0/it
Priority to US06/921,209 priority patent/US4725672A/en
Priority to DE8686114557T priority patent/DE3680857D1/de
Priority to ES198686114557T priority patent/ES2037654T3/es
Priority to EP86114557A priority patent/EP0220657B1/en
Priority to AT86114557T priority patent/ATE66152T1/de
Application granted granted Critical
Publication of IT1207507B publication Critical patent/IT1207507B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT8522559A 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. IT1207507B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
US06/921,209 US4725672A (en) 1985-10-21 1986-10-21 Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the preparation thereof and pharmaceutical compositions containing it
DE8686114557T DE3680857D1 (de) 1985-10-21 1986-10-21 Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ES198686114557T ES2037654T3 (es) 1985-10-21 1986-10-21 Conjugado de 9-(2-hidroxietoximetil)-guanina con albumina humana lactosaminada, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
EP86114557A EP0220657B1 (en) 1985-10-21 1986-10-21 Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the peparation thereof and pharmaceutical compositions containing it
AT86114557T ATE66152T1 (de) 1985-10-21 1986-10-21 Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Publications (2)

Publication Number Publication Date
IT8522559A0 IT8522559A0 (it) 1985-10-21
IT1207507B true IT1207507B (it) 1989-05-25

Family

ID=11197826

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Country Status (6)

Country Link
US (1) US4725672A (it)
EP (1) EP0220657B1 (it)
AT (1) ATE66152T1 (it)
DE (1) DE3680857D1 (it)
ES (1) ES2037654T3 (it)
IT (1) IT1207507B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245217B (it) * 1991-03-12 1994-09-13 Baldacci Lab Spa Coniugato di azidotimidina ed albumina umana procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1256110B (it) * 1992-11-23 1995-11-28 Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata
ITMI20010027A1 (it) * 2001-01-10 2002-07-10 Uni Di Bologna Dipartimento Di Composizioni teraputiche per una chemioterapia locoregionale non invasiva delle micrometastasi epatiche
US20140271772A1 (en) * 2013-03-15 2014-09-18 Barry J. Margulies Biodegradable subcutaneous implants and methods of making

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
IT1177381B (it) * 1984-12-11 1987-08-26 Baldacci Lab Spa Metodo per la preparazione di coniugati della adenina-9-beta-d-arabino furano-side 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioi terapeuticamente attive

Also Published As

Publication number Publication date
IT8522559A0 (it) 1985-10-21
EP0220657A2 (en) 1987-05-06
EP0220657B1 (en) 1991-08-14
ATE66152T1 (de) 1991-08-15
US4725672A (en) 1988-02-16
ES2037654T3 (es) 1993-07-01
DE3680857D1 (de) 1991-09-19
EP0220657A3 (en) 1988-10-05

Similar Documents

Publication Publication Date Title
DK651689A (da) Oralt autoantigenholdigt praeparat
FR2417500A1 (fr) Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
DK0397060T3 (da) Maleinimidderivater og deres anvendelse som lægemidler
FR2453158A1 (fr) Nouveaux acides benzimidazolyl-acetohydroxamiques, leur procede de preparation et leur application en therapeutique
BE898749A (fr) Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic
BG49827A3 (bg) Метод за получаване на пречистен биологично активен рекомбинантен човешки колоний стимулиращ фактор
ES2054715T3 (es) Nuevos derivados de naftaleno y productos farmaceuticos antialergicos y antiinflamatorios.
ES2037808T3 (es) Procedimiento para la obtencion de medicamentos para la profilaxis y terapia de enfermedades producidas por retrovirus.
NO882239L (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
NO882238D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
FI94354C (fi) Menetelmä farmaseuttisesti aktiivisten peptidien valmistamiseksi
DK627987A (da) Farmaceutiske praeparater
FR2565825B1 (fr) Vaccin contre les maladies dues a des microorganismes tels que des mycoplasmes, sa preparation et membranes de microorganismes en tant que principe actif
EP0220657A3 (en) Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the peparation thereof and pharmaceutical compositions containing it
FR2387214A1 (fr) Derives du p-aminomethyl benzene-sulfonamide, leur procede de preparation et leur application therapeutique
AU566974B2 (en) Pharmaceutical preparations containing a phospholipidan an oxicam derivative
ES2016464A6 (es) Procedimiento para preparar derivados de 2', 5' -oligoadenilato.
FR2618436B1 (fr) Derives de piperidine, leur preparation et leur application en therapeutique
DK102787A (da) Isohexidnucleosider og farmaceutiske praeparater indeholdende disse
FR2385735A1 (fr) Nouveaux derives semi-synthetiques de 4''-deoxy-erythromycine a et medicament les contenant
ATE130192T1 (de) Verwendung von 15-deoxyspergualin als arzneimittel.
DE3751602D1 (de) Subkutane Verabreichung des humanen Choriongonadotropins.
FR2434150A1 (fr) Derives d'acides hydroxamiques et medicaments qui en contiennent
IT8719427A0 (it) Procedimento per la preparazione di agenti per il trattamento diprodotti gassosi della combustione.
IT8423998A1 (it) Metodo per la preparazione di coniugati della adenina-9- B -D-arabino furanoside 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioni terapeuticamente attive

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971212