IT1207507B - Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. - Google Patents

Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Info

Publication number
IT1207507B
IT1207507B IT8522559A IT2255985A IT1207507B IT 1207507 B IT1207507 B IT 1207507B IT 8522559 A IT8522559 A IT 8522559A IT 2255985 A IT2255985 A IT 2255985A IT 1207507 B IT1207507 B IT 1207507B
Authority
IT
Italy
Prior art keywords
hydroxyethoxymethyl
guanine
conjugate
human albumin
preparation
Prior art date
Application number
IT8522559A
Other languages
English (en)
Other versions
IT8522559A0 (it
Inventor
Massimo Balducci
Luigi Fiume
Corrado Busi
Alessandro Mattioli
Original Assignee
Baldacci Lab Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baldacci Lab Spa filed Critical Baldacci Lab Spa
Priority to IT8522559A priority Critical patent/IT1207507B/it
Publication of IT8522559A0 publication Critical patent/IT8522559A0/it
Priority to EP86114557A priority patent/EP0220657B1/en
Priority to US06/921,209 priority patent/US4725672A/en
Priority to AT86114557T priority patent/ATE66152T1/de
Priority to ES198686114557T priority patent/ES2037654T3/es
Priority to DE8686114557T priority patent/DE3680857D1/de
Application granted granted Critical
Publication of IT1207507B publication Critical patent/IT1207507B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT8522559A 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono. IT1207507B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
EP86114557A EP0220657B1 (en) 1985-10-21 1986-10-21 Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the peparation thereof and pharmaceutical compositions containing it
US06/921,209 US4725672A (en) 1985-10-21 1986-10-21 Conjugate of 9-(2-hydroxyethoxymethyl)-guanine with lactosaminated human albumin, process for the preparation thereof and pharmaceutical compositions containing it
AT86114557T ATE66152T1 (de) 1985-10-21 1986-10-21 Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
ES198686114557T ES2037654T3 (es) 1985-10-21 1986-10-21 Conjugado de 9-(2-hidroxietoximetil)-guanina con albumina humana lactosaminada, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
DE8686114557T DE3680857D1 (de) 1985-10-21 1986-10-21 Reaktionsverbindung von 9-(2-hydroxyethoxymethyl)-guanin mit lactosaminiertem menschlichem albumin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Publications (2)

Publication Number Publication Date
IT8522559A0 IT8522559A0 (it) 1985-10-21
IT1207507B true IT1207507B (it) 1989-05-25

Family

ID=11197826

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8522559A IT1207507B (it) 1985-10-21 1985-10-21 Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.

Country Status (6)

Country Link
US (1) US4725672A (it)
EP (1) EP0220657B1 (it)
AT (1) ATE66152T1 (it)
DE (1) DE3680857D1 (it)
ES (1) ES2037654T3 (it)
IT (1) IT1207507B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1245217B (it) * 1991-03-12 1994-09-13 Baldacci Lab Spa Coniugato di azidotimidina ed albumina umana procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1256110B (it) * 1992-11-23 1995-11-28 Procedimento di coniugazione di nucleosidi antivirali con albumina umana lattosaminata
ITMI20010027A1 (it) * 2001-01-10 2002-07-10 Uni Di Bologna Dipartimento Di Composizioni teraputiche per una chemioterapia locoregionale non invasiva delle micrometastasi epatiche
US20140271772A1 (en) * 2013-03-15 2014-09-18 Barry J. Margulies Biodegradable subcutaneous implants and methods of making

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
IT1177381B (it) * 1984-12-11 1987-08-26 Baldacci Lab Spa Metodo per la preparazione di coniugati della adenina-9-beta-d-arabino furano-side 5' monofosfato con albumina umana lattosaminata, coniugati risultanti e relative composizioi terapeuticamente attive

Also Published As

Publication number Publication date
EP0220657B1 (en) 1991-08-14
US4725672A (en) 1988-02-16
ES2037654T3 (es) 1993-07-01
EP0220657A2 (en) 1987-05-06
DE3680857D1 (de) 1991-09-19
EP0220657A3 (en) 1988-10-05
ATE66152T1 (de) 1991-08-15
IT8522559A0 (it) 1985-10-21

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