IT1217123B - Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione - Google Patents

Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione

Info

Publication number
IT1217123B
IT1217123B IT8767076A IT6707687A IT1217123B IT 1217123 B IT1217123 B IT 1217123B IT 8767076 A IT8767076 A IT 8767076A IT 6707687 A IT6707687 A IT 6707687A IT 1217123 B IT1217123 B IT 1217123B
Authority
IT
Italy
Prior art keywords
optically active
active derivatives
acid
pentilamine
cholecistokinin
Prior art date
Application number
IT8767076A
Other languages
English (en)
Other versions
IT8767076A0 (it
Inventor
Francesco Makovec Rolan Chiste
Walter Peris
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of IT8767076A0 publication Critical patent/IT8767076A0/it
Priority to IT8767076A priority Critical patent/IT1217123B/it
Priority to DE88901259T priority patent/DE3885889T2/de
Priority to AT88901259T priority patent/ATE97653T1/de
Priority to DE3854764T priority patent/DE3854764T2/de
Priority to PCT/EP1988/000061 priority patent/WO1988005774A1/en
Priority to AT92122046T priority patent/ATE131153T1/de
Priority to EP88901259A priority patent/EP0344184B1/en
Priority to EP92122046A priority patent/EP0550899B1/en
Priority to AU12282/88A priority patent/AU606390B2/en
Priority to CA000557711A priority patent/CA1339917C/en
Priority to ZA880733A priority patent/ZA88733B/xx
Priority to JP63026417A priority patent/JPH075534B2/ja
Priority to IE30088A priority patent/IE63369B1/en
Priority to PT86700A priority patent/PT86700B/pt
Priority to DK554688A priority patent/DK172007B1/da
Application granted granted Critical
Publication of IT1217123B publication Critical patent/IT1217123B/it
Priority to US07/637,583 priority patent/US5130474A/en
Priority to US08/131,573 priority patent/US5391574A/en
Priority to US08/352,818 priority patent/US5602179A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
IT8767076A 1987-02-05 1987-02-05 Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione IT1217123B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT8767076A IT1217123B (it) 1987-02-05 1987-02-05 Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
AU12282/88A AU606390B2 (en) 1987-02-05 1988-01-28 Derivatives of (r) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity
AT88901259T ATE97653T1 (de) 1987-02-05 1988-01-28 (r)5-pentylamino-5-oxopentanesaeure-derivate mit anticholecystokininwirkung.
DE3854764T DE3854764T2 (de) 1987-02-05 1988-01-28 Verfahren zur Herstellung von (R) 5-Pentylamino-5-Oxopentanesäurederivate mit Anticholecystokininwirkung.
PCT/EP1988/000061 WO1988005774A1 (en) 1987-02-05 1988-01-28 Derivatives of (r) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity
AT92122046T ATE131153T1 (de) 1987-02-05 1988-01-28 Verfahren zur herstellung von (r) 5-pentylamino-5-oxopentanesäurederivate mit anticholecystokininwirkung.
EP88901259A EP0344184B1 (en) 1987-02-05 1988-01-28 Derivatives of (r) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity
EP92122046A EP0550899B1 (en) 1987-02-05 1988-01-28 Process for preparing derivatives of (R) 5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity
DE88901259T DE3885889T2 (de) 1987-02-05 1988-01-28 (r)5-pentylamino-5-oxopentanesäure-derivate mit anticholecystokininwirkung.
CA000557711A CA1339917C (en) 1987-02-05 1988-01-29 New potically-active derivatives of (r) 5-pentylamino- 5- oxopentanoic acid with antagonistic activity towards cholecystokinin and a method for their preparation
ZA880733A ZA88733B (en) 1987-02-05 1988-02-02 Optically-active derivatives of(r)5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokinin and a method for their preparation
JP63026417A JPH075534B2 (ja) 1987-02-05 1988-02-04 コレシストキニンに対し拮抗活性を有する（ｒ）−５−ペンチルアミノ−５−オキソペンタン酸の新規光学活性誘導体およびその製造法
IE30088A IE63369B1 (en) 1987-02-05 1988-02-04 New optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokinin and a method for their preparation
PT86700A PT86700B (pt) 1987-02-05 1988-02-04 Processo para a preparacao de novos derivados do acido (r) 5-pentilamino-5-oxo--pentanoico opticamente activos com actividade antagonista contra a colecistoquinina
DK554688A DK172007B1 (da) 1987-02-05 1988-10-04 Farmaceutisk aktive derivater af (R)-5-pentyl-amino-5-oxopentansyre og farmaceutisk præparater deraf
US07/637,583 US5130474A (en) 1987-02-05 1991-01-04 Optically-active derivatives of (r) 5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokin in and a method for their preparation
US08/131,573 US5391574A (en) 1987-02-05 1993-10-04 Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokinin and a method for their preparation
US08/352,818 US5602179A (en) 1987-02-05 1994-12-01 Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokinin and a method for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8767076A IT1217123B (it) 1987-02-05 1987-02-05 Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IT8767076A0 IT8767076A0 (it) 1987-02-05
IT1217123B true IT1217123B (it) 1990-03-14

Family

ID=11299376

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8767076A IT1217123B (it) 1987-02-05 1987-02-05 Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione

Country Status (12)

Country Link
US (3) US5130474A (it)
EP (2) EP0550899B1 (it)
JP (1) JPH075534B2 (it)
AT (1) ATE131153T1 (it)
AU (1) AU606390B2 (it)
CA (1) CA1339917C (it)
DE (2) DE3854764T2 (it)
IE (1) IE63369B1 (it)
IT (1) IT1217123B (it)
PT (1) PT86700B (it)
WO (1) WO1988005774A1 (it)
ZA (1) ZA88733B (it)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
US4971978A (en) * 1987-09-21 1990-11-20 Nadzan Alex M Derivatives of D-glutamic acid and D-aspartic acid
IE902295A1 (en) * 1989-07-07 1991-01-16 Abbott Lab Amino acid analog cck antagonists
JPH0374328A (ja) * 1989-08-04 1991-03-28 Warner Lambert Co 薬学的活性を有する中枢コレシストキニン拮抗剤
GB9200420D0 (en) * 1992-01-09 1992-02-26 James Black Foundation The Lim Amino acid derivatives
JP2578044B2 (ja) * 1992-03-14 1997-02-05 呉羽化学工業株式会社 フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤
US5716958A (en) 1994-10-27 1998-02-10 Tobishi Pharmaceutical Co., Ltd. Amino acid derivative having anti-CCK activity
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE477268T1 (de) 2003-01-28 2010-08-15 Ironwood Pharmaceuticals Inc Zusammensetzungen zur behandlung von magen-darm- störungen
US7183485B2 (en) * 2003-03-11 2007-02-27 Micron Technology, Inc. Microelectronic component assemblies having lead frames adapted to reduce package bow
ITTO20030474A1 (it) 2003-06-23 2004-12-24 Rotta Res Lab Spa Ora Rottapharm Spa Procedimento per la preparazione di dexloxiglumide
UA94412C2 (en) * 2005-07-11 2011-05-10 Уайет Glutamate aggrecanase inhibitors
US7863330B2 (en) * 2006-06-14 2011-01-04 Rottapharm S.P.A. Deloxiglumide and proton pump inhibitor combination in the treatment of gastrointestinal disorders
NZ574188A (en) 2006-07-14 2012-05-25 Ac Immune Sa Humanized antibody against amyloid beta
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
DK2170389T3 (en) * 2007-06-12 2015-01-19 Ac Immune Sa Humanized antibodies against amyloid beta
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
EP2586795B1 (en) * 2007-10-05 2018-05-16 Genentech, Inc. Use of anti-amyloid beta antibody in ocular diseases
EP2650308A3 (en) * 2007-10-05 2014-11-12 Genentech, Inc. Use of anti-amyloid beta antibody in ocular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009322285B2 (en) 2008-12-03 2016-07-28 Bausch Health Ireland Limited Formulations of guanylate cyclase C agonists and methods of use
KR20170091783A (ko) 2008-12-31 2017-08-09 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
AU2011282536B2 (en) 2010-07-30 2015-12-24 Ac Immune S.A. Safe and functional humanized anti beta-amyloid antibody
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en) 2011-03-01 2024-03-05 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
JP5785045B2 (ja) * 2011-10-06 2015-09-24 エヌ・イーケムキャット株式会社 選択的脱ベンジル化方法およびこれに用いる選択水素化触媒
AU2013304812B2 (en) 2012-08-21 2016-06-09 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
SMT201900386T1 (it) 2013-04-12 2019-09-09 Ardelyx Inc Composti nhe3-leganti e metodi per l'inibizione del trasporto di fosfato
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
US10736871B2 (en) 2015-04-01 2020-08-11 Cedars-Sinai Medical Center Anti-methanogenic lovastatin analogs or derivatives and uses thereof
AU2018205400C1 (en) 2017-01-09 2026-01-15 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス， インコーポレイテッド Ｎｈｅ媒介性アンチポートの阻害薬
CN108912007B (zh) * 2018-06-20 2021-02-26 中国农业科学院兰州畜牧与兽药研究所 一种右氯谷胺的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551417A (en) * 1967-08-28 1970-12-29 Universal Oil Prod Co Pesticidal heterocyclic sulfides
US3587048A (en) * 1969-10-10 1971-06-22 Itt Status control system
AT293368B (de) * 1969-10-13 1971-10-11 Rotta Research Lab Verfahren zur Herstellung von N-Benzoyl-L-(D- oder DL)-glutaminsäure-l-amiden
LU78804A1 (de) * 1977-12-30 1979-07-20 Byk Gulden Lomberg Chem Fab N-substituierte w-aminoalkanoyl-w-aminoalkansaeuren,ihre verwendung und verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
IE57892B1 (en) * 1984-06-25 1993-05-05 Rotta Research Lab Glutamic and aspartic acid derivatives
IT1178982B (it) * 1984-06-25 1987-09-16 Rotta Research Lab Derivati del acido gludamico aventi attivita antagonista su polipep tidi bioattivi e procedimento per la loro preparazione
IT1215169B (it) * 1985-12-17 1990-01-31 Rotta Research Lab Derivati alchil ossigenati degli acidi glutammico ed aspartico ad attivita antagonista su polipeptidi bioattivi e procedimento per la loro preparazione
IT1196849B (it) * 1986-02-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs

Also Published As

Publication number Publication date
US5130474A (en) 1992-07-14
EP0550899B1 (en) 1995-12-06
EP0344184A1 (en) 1989-12-06
AU606390B2 (en) 1991-02-07
PT86700A (pt) 1988-03-01
ATE131153T1 (de) 1995-12-15
DE3854764T2 (de) 1996-05-09
IE63369B1 (en) 1995-04-19
JPS63201156A (ja) 1988-08-19
EP0550899A1 (en) 1993-07-14
US5602179A (en) 1997-02-11
DE3885889D1 (en) 1994-01-05
IE880300L (en) 1988-08-05
DE3885889T2 (de) 1994-04-07
AU1228288A (en) 1988-08-24
WO1988005774A1 (en) 1988-08-11
US5391574A (en) 1995-02-21
IT8767076A0 (it) 1987-02-05
ZA88733B (en) 1988-08-04
CA1339917C (en) 1998-06-16
EP0344184B1 (en) 1993-11-24
JPH075534B2 (ja) 1995-01-25
DE3854764D1 (de) 1996-01-18
PT86700B (pt) 1992-04-30

Similar Documents

Publication Publication Date Title
PT86700A (pt) Process for the preparation of novel optically-active derivatives of (r) 5-pentylamino-5-oxopentanoic acid with antagonistic activity towards cholecystokinin
ES2082780T3 (es) Derivados de acido bisfosfonico heterociclicos.
NO943093L (no) Fremgangsmåte for fremstilling av clavulansyre
ES2037098T3 (es) Procedimiento de preparacion de derivados de la decahidroquinoleina.
PT91336A (pt) Processo para a preparacao de derivados lactamicos
DE3271269D1 (en) Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
ES542125A0 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina.
DE69018678D1 (de) Trizyklische Lactamderivate und pharmazeutische Zusammensetzungen, die sie enthalten.
ATE57182T1 (de) Indanderivate, herstellungsmethoden und behandlung.
NO873784D0 (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive naftalen- og indanderivater.
ES8700857A1 (es) Un procedimiento para la produccion de dihidropiridinas
ES2109216T3 (es) Un procedimiento para la preparacion de una composicion farmaceutica con actividad relajante muscular de accion central.
NO161620C (no) Analogifremgangsm te for fremstilling av terapeutisk aktive 8-alkyltio-2-piperazino-pyrimido(5,4-d)pyrimidin-derivater.
IT1211792B (it) O-alcanoil derivati dell'acido 3ammino-2-idrossipropansolfonico adattivita'anticonvulsivante e loro composizioni farmaceutiche per il trattamento terapeutico dell'epilessia
ATE48994T1 (de) Benzimidazol-derivat, verfahren zu seiner herstellung und pharmazeutische zusammensetzung.
ATE78254T1 (de) Indol-derivate.
DK160486C (da) N-(4-amino-2,2-diphenyl-butyl)- eller n-(3-amino-2,2-diphenyl-propyl) urinstofforbindelser, fremgangsmaade til fremstilling af disse, samt en farmaceutisk komposition
HUT50788A (en) Process for producing phenoxyacetic acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
AU8295887A (en) New indane derivatives, the process for preparing them and the new intermediates thereby obtained, their application as medicinal products and the compositions containing them
NO891381L (no) Fremgangsmaate for fremstilling av nye fluorfosfonatnukleotidderivater.
GEP19960472B (en) Method of producing derivative of quinoline or its pharmaceutically acceptable ester, or their salts
DE3782235D1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
EP0397615A3 (en) Pharmacologically active 2-substituted 3-(2-ethoxyethyl) imidazo [4,5-b] pyridines and pharmaceutical compositions containing them
DE3884878D1 (de) Uricosuretische Zusammensetzung.
ES2059485T3 (es) Derivados de 2-amino-1,2,3,4-tetrahidroisoquinolina, procedimiento de su preparacion y su aplicacion como medicamento.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990129