IT1223537B - Amino antracenedioni bis platino complessi utili come agenti antitumorali - Google Patents

Amino antracenedioni bis platino complessi utili come agenti antitumorali

Info

Publication number: IT1223537B
Authority: IT; Italy
Prior art keywords: ch3soch3; ch2ch2o; alkoxy; alkyl; platinum complexes
Prior art date: 1987-12-18

Application number

IT23094/87A

Other languages

English (en)

Other versions

IT8723094A0 (it

Inventor

Alessandro Pasini

Franco Zunino

Odoardo Tofanetti

Carmelo A Gandolfi

Sergio Tognella

Silvano Spinelli

Original Assignee

Boehringer Biochemia Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-18

Filing date

1987-12-18

Publication date

1990-09-19

1987-12-18 Application filed by Boehringer Biochemia Srl filed Critical Boehringer Biochemia Srl

1987-12-18 Publication of IT8723094A0 publication Critical patent/IT8723094A0/it

1987-12-18 Priority to IT23094/87A priority Critical patent/IT1223537B/it

1988-12-07 Priority to EP89900592A priority patent/EP0396588A1/en

1988-12-07 Priority to AU28175/89A priority patent/AU2817589A/en

1988-12-07 Priority to PCT/EP1988/001110 priority patent/WO1989005815A1/en

1988-12-07 Priority to JP1500325A priority patent/JPH03503046A/ja

1988-12-07 Priority to US07/499,405 priority patent/US5145848A/en

1988-12-15 Priority to ZA889413A priority patent/ZA889413B/xx

1988-12-15 Priority to CA000586002A priority patent/CA1327355C/en

1988-12-16 Priority to EP88121072A priority patent/EP0320960B1/en

1988-12-16 Priority to ES88121072T priority patent/ES2056887T3/es

1988-12-16 Priority to AT88121072T priority patent/ATE89284T1/de

1988-12-16 Priority to DE88121072T priority patent/DE3880991T2/de

1990-09-19 Application granted granted Critical

1990-09-19 Publication of IT1223537B publication Critical patent/IT1223537B/it

Links

125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 4
150000003057 platinum Chemical class 0.000 title abstract 2
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
150000001450 anions Chemical group 0.000 abstract 1
LSOTZYUVGZKSHR-UHFFFAOYSA-N anthracene-1,4-dione Chemical compound C1=CC=C2C=C3C(=O)C=CC(=O)C3=CC2=C1 LSOTZYUVGZKSHR-UHFFFAOYSA-N 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
229940093499 ethyl acetate Drugs 0.000 abstract 1
235000019439 ethyl acetate Nutrition 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT23094/87A 1987-12-18 1987-12-18 Amino antracenedioni bis platino complessi utili come agenti antitumorali IT1223537B (it)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
IT23094/87A IT1223537B (it)	1987-12-18	1987-12-18	Amino antracenedioni bis platino complessi utili come agenti antitumorali
EP89900592A EP0396588A1 (en)	1987-12-18	1988-12-07	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
AU28175/89A AU2817589A (en)	1987-12-18	1988-12-07	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
PCT/EP1988/001110 WO1989005815A1 (en)	1987-12-18	1988-12-07	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
JP1500325A JPH03503046A (ja)	1987-12-18	1988-12-07	抗腫瘍剤として有用なアミノアントラセンジオン‐ビス白金錯体
US07/499,405 US5145848A (en)	1987-12-18	1988-12-07	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
ZA889413A ZA889413B (en)	1987-12-18	1988-12-15	Amino anthracenediones-bis platinum complexes,useful as antitumoral agents
CA000586002A CA1327355C (en)	1987-12-18	1988-12-15	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
EP88121072A EP0320960B1 (en)	1987-12-18	1988-12-16	Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
ES88121072T ES2056887T3 (es)	1987-12-18	1988-12-16	Complejos de amino-antracenodiona-bis-platino, utiles como agentes antitumorales.
AT88121072T ATE89284T1 (de)	1987-12-18	1988-12-16	Aminoanthracendion-bis-platinkomplexe, nuetzlich als antitumor-agenzien.
DE88121072T DE3880991T2 (de)	1987-12-18	1988-12-16	Aminoanthracendion-bis-platinkomplexe, nützlich als Antitumor-Agenzien.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23094/87A IT1223537B (it)	1987-12-18	1987-12-18	Amino antracenedioni bis platino complessi utili come agenti antitumorali

Publications (2)

Publication Number	Publication Date
IT8723094A0 IT8723094A0 (it)	1987-12-18
IT1223537B true IT1223537B (it)	1990-09-19

Family

ID=11203721

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT23094/87A IT1223537B (it)	1987-12-18	1987-12-18	Amino antracenedioni bis platino complessi utili come agenti antitumorali

Country Status (2)

Country	Link
IT (1)	IT1223537B (it)
ZA (1)	ZA889413B (it)

1987
- 1987-12-18 IT IT23094/87A patent/IT1223537B/it active
1988
- 1988-12-15 ZA ZA889413A patent/ZA889413B/xx unknown

Also Published As

Publication number	Publication date
ZA889413B (en)	1990-08-29
IT8723094A0 (it)	1987-12-18

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19931230