IT1226859B - Procedimento per la preparazione di acidi fosfinici utilizzati nella preparazione di inibitori di ace ed intermedi cosi' prodotti. - Google Patents

Procedimento per la preparazione di acidi fosfinici utilizzati nella preparazione di inibitori di ace ed intermedi cosi' prodotti.

Info

Publication number: IT1226859B
Authority: IT; Italy
Prior art keywords: preparation; intermediates; procedure; produced; acids used
Prior art date: 1987-09-30

Application number

IT8822122A

Other languages

English (en)

Other versions

IT8822122A0 (it

Inventor

Edward W Petrillo Jr

Donald S Karanewsky

John K Thottathil

James E Heikes

John A Grosso

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-30

Filing date

1988-09-29

Publication date

1991-02-19

1988-09-29 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1988-09-29 Publication of IT8822122A0 publication Critical patent/IT8822122A0/it

1991-02-19 Application granted granted Critical

1991-02-19 Publication of IT1226859B publication Critical patent/IT1226859B/it

Links

239000005541 ACE inhibitor Substances 0.000 title 1
239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IT8822122A 1987-09-30 1988-09-29 Procedimento per la preparazione di acidi fosfinici utilizzati nella preparazione di inibitori di ace ed intermedi cosi' prodotti. IT1226859B (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/102,694 US4873356A (en)	1987-09-30	1987-09-30	Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby

Publications (2)

Publication Number	Publication Date
IT8822122A0 IT8822122A0 (it)	1988-09-29
IT1226859B true IT1226859B (it)	1991-02-19

Family

ID=22291193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8822122A IT1226859B (it)	1987-09-30	1988-09-29	Procedimento per la preparazione di acidi fosfinici utilizzati nella preparazione di inibitori di ace ed intermedi cosi' prodotti.

Country Status (12)

Country	Link
US (1)	US4873356A (it)
JP (1)	JP2716746B2 (it)
KR (1)	KR890005133A (it)
CN (1)	CN1032443A (it)
CA (1)	CA1336433C (it)
DE (1)	DE3833082A1 (it)
FI (1)	FI884200A7 (it)
FR (1)	FR2623811B1 (it)
GB (1)	GB2210370B (it)
HU (1)	HU205126B (it)
IE (1)	IE61587B1 (it)
IT (1)	IT1226859B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008399A (en) *	1990-01-19	1991-04-16	E. R. Squibb & Sons, Inc.	Diastereoselective preparation of phosphinate esters
US6384022B1 (en) *	1996-06-17	2002-05-07	Guilford Pharmaceuticals Inc.	Prodrugs of NAALAdase inhibitors
EP1383779B1 (en) *	2001-04-30	2004-10-13	Lupin Laboratories Limited	A process for manufacture of fosinopril sodium
KR100690647B1 (ko)	2004-07-29	2007-03-09	엘지전자 주식회사	바스켓 승강장치를 구비한 냉장고
CN100488969C (zh) *	2005-10-27	2009-05-20	上海医药工业研究院	光学活性的取代氧膦基乙酸盐及其用途
CN100497335C (zh) *	2005-10-27	2009-06-10	上海医药工业研究院	取代氧膦基乙酸的光学拆分方法
IT1394407B1 (it) *	2009-05-25	2012-06-15	Dipharma Francis Srl	Procedimento per la preparazione di fosinopril e suoi intermedi
IT1406151B1 (it)	2010-12-06	2014-02-14	Dipharma Francis Srl	Procedimento per la preparazione di fosinopril e suoi intermedi

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4396772A (en) *	1981-11-23	1983-08-02	F. R. Squibb & Sons, Inc.	Phosphinylalkanoyl amino acids
US4448772A (en) *	1982-04-22	1984-05-15	E. R. Squibb & Sons, Inc.	Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4468519A (en) *	1982-06-14	1984-08-28	E. R. Squibb & Sons, Inc.	Esters of phosphinylalkanoyl substituted prolines
US4602092A (en) *	1983-09-19	1986-07-22	E. R. Squibb & Sons, Inc.	Method for making phosphinic acid intermediates

1987
- 1987-09-30 US US07/102,694 patent/US4873356A/en not_active Expired - Lifetime
1988
- 1988-08-31 CA CA000576217A patent/CA1336433C/en not_active Expired - Fee Related
- 1988-09-13 FI FI884200A patent/FI884200A7/fi not_active Application Discontinuation
- 1988-09-27 GB GB8822596A patent/GB2210370B/en not_active Expired - Lifetime
- 1988-09-29 IT IT8822122A patent/IT1226859B/it active
- 1988-09-29 KR KR1019880012595A patent/KR890005133A/ko not_active Ceased
- 1988-09-29 HU HU885069A patent/HU205126B/hu unknown
- 1988-09-29 DE DE3833082A patent/DE3833082A1/de not_active Ceased
- 1988-09-29 CN CN88109034A patent/CN1032443A/zh active Pending
- 1988-09-29 FR FR888812769A patent/FR2623811B1/fr not_active Expired - Lifetime
- 1988-09-30 JP JP63248943A patent/JP2716746B2/ja not_active Expired - Lifetime
- 1988-10-29 IE IE293888A patent/IE61587B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH01106894A (ja)	1989-04-24
KR890005133A (ko)	1989-05-13
GB8822596D0 (en)	1988-11-02
IE882938L (en)	1989-03-30
IE61587B1 (en)	1994-11-16
FI884200A7 (fi)	1989-03-31
US4873356A (en)	1989-10-10
HUT48632A (en)	1989-06-28
CN1032443A (zh)	1989-04-19
HU205126B (en)	1992-03-30
JP2716746B2 (ja)	1998-02-18
GB2210370A (en)	1989-06-07
DE3833082A1 (de)	1989-04-13
CA1336433C (en)	1995-07-25
GB2210370B (en)	1992-01-15
FR2623811B1 (fr)	1991-11-15
FI884200A0 (fi)	1988-09-13
FR2623811A1 (fr)	1989-06-02
IT8822122A0 (it)	1988-09-29

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970929