IT1230493B - Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da - Google Patents

Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da

Info

Publication number: IT1230493B
Authority: IT; Italy
Prior art keywords: prodn; melatonin; methoxy; reacting; tryptamine
Prior art date: 1988-09-08

Application number

IT8821872A

Other languages

English (en)

Other versions

IT8821872A0 (it

Inventor

Luigi Di Bella

Ermanno Duranti

Franco Fraschini

Original Assignee

I F L O Di Giorgio Ed Aldo Lag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-08

Filing date

1988-09-08

Publication date

1991-10-24

1988-09-08 Application filed by I F L O Di Giorgio Ed Aldo Lag filed Critical I F L O Di Giorgio Ed Aldo Lag

1988-09-08 Publication of IT8821872A0 publication Critical patent/IT8821872A0/it

1988-09-08 Priority to IT8821872A priority Critical patent/IT1230493B/it

1989-02-16 Priority to DE68925135T priority patent/DE68925135T2/de

1989-02-16 Priority to AT89830055T priority patent/ATE131812T1/de

1989-02-16 Priority to EP89830055A priority patent/EP0330625B1/en

1989-02-16 Priority to ES89830055T priority patent/ES2083390T3/es

1989-02-17 Priority to US07/312,627 priority patent/US5122535A/en

1989-02-23 Priority to JP1045068A priority patent/JP2724493B2/ja

1991-10-24 Application granted granted Critical

1991-10-24 Publication of IT1230493B publication Critical patent/IT1230493B/it

1994-06-02 Priority to US08/252,905 priority patent/USRE35631E/en

1996-03-19 Priority to GR960400765T priority patent/GR3019365T3/el

Links

JTEJPPKMYBDEMY-UHFFFAOYSA-N 5-methoxytryptamine Chemical compound COC1=CC=C2NC=C(CCN)C2=C1 JTEJPPKMYBDEMY-UHFFFAOYSA-N 0.000 title abstract 4
YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title abstract 3
DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title abstract 3
229940097276 5-methoxytryptamine Drugs 0.000 title abstract 2
229960003987 melatonin Drugs 0.000 title abstract 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
XDGCOSMBEZEXSN-UHFFFAOYSA-N ethyl 2-acetyl-5-(1,3-dioxoisoindol-2-yl)pentanoate Chemical compound C1=CC=C2C(=O)N(CCCC(C(=O)OCC)C(C)=O)C(=O)C2=C1 XDGCOSMBEZEXSN-UHFFFAOYSA-N 0.000 abstract 3
VKJCJJYNVIYVQR-UHFFFAOYSA-N 2-(3-bromopropyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCCBr)C(=O)C2=C1 VKJCJJYNVIYVQR-UHFFFAOYSA-N 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
230000000397 acetylating effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
AGZWJQDJMAWCAW-UHFFFAOYSA-N ethyl 3-[2-(1,3-dioxoisoindol-2-yl)ethyl]-5-methoxy-1h-indole-2-carboxylate Chemical compound O=C1C2=CC=CC=C2C(=O)N1CCC1=C(C(=O)OCC)NC2=CC=C(OC)C=C21 AGZWJQDJMAWCAW-UHFFFAOYSA-N 0.000 abstract 1
XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 abstract 1
XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
235000011149 sulphuric acid Nutrition 0.000 abstract 1

Landscapes

Indole Compounds (AREA)

IT8821872A 1988-02-25 1988-09-08 Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da IT1230493B (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT8821872A IT1230493B (it)	1988-09-08	1988-09-08	Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da
ES89830055T ES2083390T3 (es)	1988-02-25	1989-02-16	Procedimiento de sintesis total para preparar una clase de producto derivado de estructura indol, del tipo triptamina, en particular la melatonia o la n-acetil-5-metoxitriptamina, con un elevado grado de pureza y facilmente soluble, para uso terapeutico contra los sindromes de la
AT89830055T ATE131812T1 (de)	1988-02-25	1989-02-16	Verfahren zur totalen synthese von einer indol- struktur-verbindungsklasse des tryptamin-typs, insbesondere melatonin- oder n-acetyl-5- methoxytryptamin mit hoher reinheit und löslichkeit, verwendbar in der aids-therapie
EP89830055A EP0330625B1 (en)	1988-02-25	1989-02-16	Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes
DE68925135T DE68925135T2 (de)	1988-02-25	1989-02-16	Verfahren zur totalen Synthese von einer Indol-Struktur-Verbindungsklasse des Tryptamin-Typs, insbesondere Melatonin- oder N-Acetyl-5-methoxytryptamin mit hoher Reinheit und Löslichkeit, verwendbar in der AIDS-Therapie
US07/312,627 US5122535A (en)	1988-02-25	1989-02-17	Method of solubilizing melatonine in water
JP1045068A JP2724493B2 (ja)	1988-02-25	1989-02-23	５−メトキシトリプタミン及びトリプタミン誘導体の合成方法
US08/252,905 USRE35631E (en)	1988-02-25	1994-06-02	Method of production of essentially pure melatonin and the method of solubilizing melatonin in water
GR960400765T GR3019365T3 (en)	1988-02-25	1996-03-19	Total synthesis method for making an indole structure derivative product class, of the triptamine type, in particular, melatonin or N-acetyl-5-methoxytriptamine type, having a high purity degree and easily soluble, for therapeutic use against acquired immuno-deficiency syndromes

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8821872A IT1230493B (it)	1988-09-08	1988-09-08	Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da

Publications (2)

Publication Number	Publication Date
IT8821872A0 IT8821872A0 (it)	1988-09-08
IT1230493B true IT1230493B (it)	1991-10-24

Family

ID=11188049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8821872A IT1230493B (it)	1988-02-25	1988-09-08	Procedimento di sintesi totale, per l'ottenimento di una categoria di prodotti derivati a struttura indolica del tipo della triptamina in particolare di melatonina o n-aceti 5-metossitriptamina ad elevato grado di purezza e facilmente solubile utilizzabile in specie per impieghi terapeutici e quale farmaco per la cura delle sindromi da

Country Status (1)

Country	Link
IT (1)	IT1230493B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN113968809B (zh) *	2021-11-05	2024-08-30	太阳树(莆田)生物医药有限公司	一种褪黑素的化学合成方法

1988
- 1988-09-08 IT IT8821872A patent/IT1230493B/it active

Also Published As

Publication number	Publication date
IT8821872A0 (it)	1988-09-08

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970925