IT1232160B - 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono - Google Patents

2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono

Info

Publication number
IT1232160B
IT1232160B IT8948254A IT4825489A IT1232160B IT 1232160 B IT1232160 B IT 1232160B IT 8948254 A IT8948254 A IT 8948254A IT 4825489 A IT4825489 A IT 4825489A IT 1232160 B IT1232160 B IT 1232160B
Authority
IT
Italy
Prior art keywords
amino
tetraline
dimetoxy
acil
procedure
Prior art date
Application number
IT8948254A
Other languages
English (en)
Other versions
IT8948254A0 (it
Inventor
Carla Franceschelli
Massimo Castorina
Mauro Marzi
Maria Ornella Tinti
Licia Pacifici
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT8948254A0 publication Critical patent/IT8948254A0/it
Priority to IT8948254A priority Critical patent/IT1232160B/it
Priority to DE69013101T priority patent/DE69013101T2/de
Priority to ES90830347T priority patent/ES2062492T3/es
Priority to EP90830347A priority patent/EP0412061B1/en
Priority to AT90830347T priority patent/ATE112550T1/de
Priority to DK90830347.2T priority patent/DK0412061T3/da
Priority to JP2203746A priority patent/JP2806608B2/ja
Priority to US07/559,052 priority patent/US5053424A/en
Application granted granted Critical
Publication of IT1232160B publication Critical patent/IT1232160B/it
Priority to HK98104931.7A priority patent/HK1005857B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
IT8948254A 1989-07-31 1989-07-31 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono IT1232160B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8948254A IT1232160B (it) 1989-07-31 1989-07-31 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono
AT90830347T ATE112550T1 (de) 1989-07-31 1990-07-26 2-(n-acyl)amino-6,7-dimethoxytetraline, verfahren zu deren herstellung und pharmazeutische zusammensetzungen mit antihypertensiver wirkung, die diese enthalten.
ES90830347T ES2062492T3 (es) 1989-07-31 1990-07-26 2-(n-acil)amino-6,7-dimetoxi tetralinas, procedimiento para su preparacion y composiciones farmaceuticas con actividad antihipertensiva que las contienen.
EP90830347A EP0412061B1 (en) 1989-07-31 1990-07-26 2-(N-acyl)amino-6,7-dimethoxy tetralines, process for their preparation and pharmaceutical compositions having antihypertensive activity containing same
DE69013101T DE69013101T2 (de) 1989-07-31 1990-07-26 2-(N-acyl)amino-6,7-dimethoxytetraline, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen mit antihypertensiver Wirkung, die diese enthalten.
DK90830347.2T DK0412061T3 (da) 1989-07-31 1990-07-26 2-(N-acyl)amino-6,7-dimethoxytetraliner, fremgangsmåde til fremstilling heraf og farmaceutiske præparater med antihypertensiv aktivitet indeholdende disse
JP2203746A JP2806608B2 (ja) 1989-07-31 1990-07-30 ２―（ｎ―アシル）アミノ―６，７―ジメトキシテトラリン、製法および抗高血圧剤
US07/559,052 US5053424A (en) 1989-07-31 1990-07-30 2-(n-acyl)amino-6,7-dimethoxy tetralines, and pharmaceutical compositions having antihypertensive activity containing same
HK98104931.7A HK1005857B (en) 1989-07-31 1998-06-05 2-(n-acyl)amino-6,7-dimethoxy tetralines, process for their preparation and pharmaceutical compositions having antihypertensive activity containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8948254A IT1232160B (it) 1989-07-31 1989-07-31 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono

Publications (2)

Publication Number Publication Date
IT8948254A0 IT8948254A0 (it) 1989-07-31
IT1232160B true IT1232160B (it) 1992-01-25

Family

ID=11265513

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8948254A IT1232160B (it) 1989-07-31 1989-07-31 2-(n-acil)ammino-6,7-dimetossi tetraline, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' antiipertensiva che le contengono

Country Status (8)

Country Link
US (1) US5053424A (it)
EP (1) EP0412061B1 (it)
JP (1) JP2806608B2 (it)
AT (1) ATE112550T1 (it)
DE (1) DE69013101T2 (it)
DK (1) DK0412061T3 (it)
ES (1) ES2062492T3 (it)
IT (1) IT1232160B (it)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981872A (en) * 1972-10-06 1976-09-21 A. Christiaens Societe Anonyme Derivatives of 2-amino-(1,2,3,4-tetrahydronaphthalene)
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
CA1261855A (en) * 1986-04-11 1989-09-26 Alenka Paquet Derivatives of d-amino acids having anti-microbial properties

Also Published As

Publication number Publication date
EP0412061A3 (en) 1991-08-14
HK1005857A1 (en) 1999-01-29
US5053424A (en) 1991-10-01
IT8948254A0 (it) 1989-07-31
EP0412061B1 (en) 1994-10-05
DE69013101D1 (de) 1994-11-10
JPH03178955A (ja) 1991-08-02
DE69013101T2 (de) 1995-02-23
ES2062492T3 (es) 1994-12-16
JP2806608B2 (ja) 1998-09-30
EP0412061A2 (en) 1991-02-06
ATE112550T1 (de) 1994-10-15
DK0412061T3 (da) 1994-10-31

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970609