IT1245853B - 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono - Google Patents

1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Info

Publication number
IT1245853B
IT1245853B IT02208890A IT2208890A IT1245853B IT 1245853 B IT1245853 B IT 1245853B IT 02208890 A IT02208890 A IT 02208890A IT 2208890 A IT2208890 A IT 2208890A IT 1245853 B IT1245853 B IT 1245853B
Authority
IT
Italy
Prior art keywords
mono
hydroxy
alchyl
polyhydroxy
aminocarbonyl
Prior art date
Application number
IT02208890A
Other languages
English (en)
Other versions
IT9022088A1 (it
IT9022088A0 (it
Inventor
Fulvio Uggeri
Marino Brocchetta
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of IT9022088A0 publication Critical patent/IT9022088A0/it
Priority to IT02208890A priority Critical patent/IT1245853B/it
Priority to IS3781A priority patent/IS3781A7/is
Priority to NZ240566A priority patent/NZ240566A/en
Priority to IL10005491A priority patent/IL100054A/en
Priority to DK91919864.8T priority patent/DK0557345T3/da
Priority to AU89253/91A priority patent/AU646119B2/en
Priority to DE69104059T priority patent/DE69104059T2/de
Priority to HU9301375A priority patent/HUT65652A/hu
Priority to PCT/EP1991/002151 priority patent/WO1992008691A1/en
Priority to EP91919864A priority patent/EP0557345B1/en
Priority to DE0557345T priority patent/DE557345T1/de
Priority to CA002096136A priority patent/CA2096136A1/en
Priority to AT91919864T priority patent/ATE111441T1/de
Priority to MX9102103A priority patent/MX9102103A/es
Priority to ES91919864T priority patent/ES2060415T3/es
Priority to JP3517985A priority patent/JP2977613B2/ja
Priority to IE398691A priority patent/IE66460B1/en
Priority to ZA919065A priority patent/ZA919065B/xx
Publication of IT9022088A1 publication Critical patent/IT9022088A1/it
Priority to KR1019930701423A priority patent/KR930702281A/ko
Priority to GR930300134T priority patent/GR930300134T1/el
Application granted granted Critical
Publication of IT1245853B publication Critical patent/IT1245853B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT02208890A 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono IT1245853B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
IS3781A IS3781A7 (is) 1990-11-16 1991-11-11 1,3-Bis-[3- (mono-eða poly-hydroxy) acylamino-5- (mono-eða poly-hydroxy-alkyl) aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- eða hydroxy-alkyl-própan efni, aðferðir til framleiðslu þeirra og röntgengeisla-skuggaefni sem innihalda þau
NZ240566A NZ240566A (en) 1990-11-16 1991-11-12 Symmetrical and asymmetrical 1,3-bis-[3-(mono- or
IL10005491A IL100054A (en) 1990-11-16 1991-11-14 1,3-bis-[3-(mono- or poly-hydroxy) acylamino-5-(mono- or poly-hydroxyalkyl) aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes their methods of preparation and x-ray contrast media containing them
DE0557345T DE557345T1 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
MX9102103A MX9102103A (es) 1990-11-16 1991-11-15 Compuestos de contraste para diagnosticos con rayos x, procedimiento para su preparacion y composiciones que los contienen.
DE69104059T DE69104059T2 (de) 1990-11-16 1991-11-15 1,3-bis-[3-(mono-[oder polyhydroxy)acylamino-5-(mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6-trijodobenzoylamino]-hydroxy- oder hydroxyalkyl-propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
HU9301375A HUT65652A (en) 1990-11-16 1991-11-15 Process for producing 1,3-bis-/3-(mono- or poly-hydroxy)acylamino-5-(mono-or polyhydroxyalkyl)-aminocarbonyl-2,4,6-triiodo-benzoyl-amino/-hydroxy- or hydroxyalkyl-propanes and x-ray contrast media containing them
PCT/EP1991/002151 WO1992008691A1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
EP91919864A EP0557345B1 (en) 1990-11-16 1991-11-15 1,3-bis- 3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
DK91919864.8T DK0557345T3 (da) 1990-11-16 1991-11-15 1,3-bis-(3-(mono- eller polyhydroxy)acylamino-5-(mono- eller polyhydroxyalkyl)aminocarbonyl-2,4,6- trijodbenzoylamino)-hydroxy- eller -hydroxyalkylpropaner, fremgangsmåder til fremstilling heraf samt røntgenkontrastmidler indeholdende disse
CA002096136A CA2096136A1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5- (mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6- triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them
AT91919864T ATE111441T1 (de) 1990-11-16 1991-11-15 1,3-bis-(3-(mono-(oder polyhydroxy)acylamino-5- (mono- oder polyhydroxyalkyl)aminocarbonyl-2,4,6- trijodobenzoylamino>-hydroxy- oder hydroxyalkyl- propane, deren herstellung und diese enthaltende röntgenkontrastmittel.
AU89253/91A AU646119B2 (en) 1990-11-16 1991-11-15 1,3-bis-(3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino) -hydroxy- or hydroxyalkyl-propanes, their methods of preparation and X-ray contrast media containing them
ES91919864T ES2060415T3 (es) 1990-11-16 1991-11-15 1,3-bis(3-(mono- o poli-hidroxi)acilamino-5-(mono- o polihidroxialquil)aminocarbonil-2,4,6-triyodo-benzoilamino)hidroxi- o hidroxialquil-propanos, procedimiento para su preparacion y medios de contraste para rayos x que los contienen.
JP3517985A JP2977613B2 (ja) 1990-11-16 1991-11-15 １，３−ビス−［３−（モノ−またはポリ−ヒドロキシ）アシルアミノ−５−（モノ−またはポリ−ヒドロキシアルキル）アミノカルボニル−２，４，６−トリヨ−ド−ベンゾイル−アミノ］−ヒドロキシ−またはヒドロキシアルキル−プロパン類、それらの製造法、およびそれらを含有する造影剤
IE398691A IE66460B1 (en) 1990-11-16 1991-11-15 1,3-bis-[3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino]-hydroxy- or hydroxyalkyl-propanes their methods of preparation and X-ray contrast media containing them
ZA919065A ZA919065B (en) 1990-11-16 1991-11-15 1,3-bis-(3-(mono-or poly-hydroxy)acylamino-5-(mono-or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino)-hydroxy-or hydroxyalkyl-propanes,their methods of preparation and x-ray contrast media containing them
KR1019930701423A KR930702281A (ko) 1990-11-16 1993-05-12 1,3-비스-[3-아미노카르보닐-2,4,6-트리요오도-벤조일-아미노]-히드록시- 또는 히드록시알킬-프로판, 그의 제조 방법 및 그를 함유하는 x선 조영 매체
GR930300134T GR930300134T1 (en) 1990-11-16 1994-02-28 1,3-bis- 3-(mono- or poly-hydroxy)acylamino-5-(mono- or poly-hydroxyalkyl)aminocarbonyl-2,4,6-triiodo-benzoyl-amino)-hydroxy- or hydroxyalkyl-propanes, their methods of preparation and x-ray contrast media containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Publications (3)

Publication Number Publication Date
IT9022088A0 IT9022088A0 (it) 1990-11-16
IT9022088A1 IT9022088A1 (it) 1992-05-17
IT1245853B true IT1245853B (it) 1994-10-25

Family

ID=11191331

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02208890A IT1245853B (it) 1990-11-16 1990-11-16 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Country Status (19)

Country Link
EP (1) EP0557345B1 (it)
JP (1) JP2977613B2 (it)
KR (1) KR930702281A (it)
AT (1) ATE111441T1 (it)
AU (1) AU646119B2 (it)
CA (1) CA2096136A1 (it)
DE (2) DE69104059T2 (it)
DK (1) DK0557345T3 (it)
ES (1) ES2060415T3 (it)
GR (1) GR930300134T1 (it)
HU (1) HUT65652A (it)
IE (1) IE66460B1 (it)
IL (1) IL100054A (it)
IS (1) IS3781A7 (it)
IT (1) IT1245853B (it)
MX (1) MX9102103A (it)
NZ (1) NZ240566A (it)
WO (1) WO1992008691A1 (it)
ZA (1) ZA919065B (it)

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FR2717799B1 (fr) * 1994-03-22 1996-07-19 Guerbet Sa Composés polyiodes : procédé de préparation ; composition de diagnostic.
EP1465678B1 (en) 2001-12-20 2007-06-27 Bone Support AB A new bone mineral substitute
EP1765812B1 (en) 2004-07-02 2009-04-29 Bracco Imaging S.p.A Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
US7407647B2 (en) * 2005-12-07 2008-08-05 Cordis Corporation Organic radiographic contrasting agents for medical devices
US20070134163A1 (en) 2005-12-13 2007-06-14 Zhao Jonathon Z Radiographic contrasting agents and radio-opaque polymeric materials for medical devices
EP1989178B1 (en) * 2006-02-14 2012-10-31 Ge Healthcare As Contrast agents
DK2178568T3 (da) 2007-07-12 2014-07-21 Ge Healthcare As Kontrastmidler
CN101820922A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
CN101821231A (zh) * 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
EP2203189B1 (en) * 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
GB2453654A (en) * 2007-10-12 2009-04-15 Ge Healthcare As A compound for use in X-ray contrast examinations
EP2203190A1 (en) * 2007-10-30 2010-07-07 GE Healthcare AS Contrast agents
EP2231200A1 (en) * 2007-12-05 2010-09-29 GE Healthcare AS Contrast agents
WO2009097277A1 (en) * 2008-02-01 2009-08-06 Trustees Of Boston University Cationic contrast agents and methods of use thereof
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
US11065201B2 (en) 2014-11-21 2021-07-20 Technical University Of Denmark Gel formulations for local drug release
WO2016123583A1 (en) 2015-01-29 2016-08-04 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
AU2017266410B2 (en) 2016-05-20 2022-07-14 Nanovi Radiotherapy Aps Palpable marker composition
US10639157B2 (en) 2017-03-14 2020-05-05 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
CA3143104A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
WO2025062996A1 (ja) * 2023-09-22 2025-03-27 国立大学法人九州大学 化学誘起動的核偏極プローブ、化合物および化学誘起機能評価方法

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* Cited by examiner, † Cited by third party
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GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
CH626873A5 (it) * 1977-03-28 1981-12-15 Bracco Ind Chimica Spa
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel

Also Published As

Publication number Publication date
MX9102103A (es) 1992-06-01
HU9301375D0 (en) 1993-09-28
JPH06504268A (ja) 1994-05-19
GR930300134T1 (en) 1994-02-28
DE69104059T2 (de) 1995-02-02
HUT65652A (en) 1994-07-28
EP0557345B1 (en) 1994-09-14
NZ240566A (en) 1994-02-25
IE66460B1 (en) 1995-12-27
IE913986A1 (en) 1992-05-20
KR930702281A (ko) 1993-09-08
IT9022088A1 (it) 1992-05-17
DE557345T1 (de) 1994-07-28
WO1992008691A1 (en) 1992-05-29
ATE111441T1 (de) 1994-09-15
CA2096136A1 (en) 1992-05-17
DK0557345T3 (da) 1995-03-06
IL100054A0 (en) 1992-08-18
ZA919065B (en) 1992-08-26
AU646119B2 (en) 1994-02-10
IS3781A7 (is) 1992-05-17
AU8925391A (en) 1992-06-11
IT9022088A0 (it) 1990-11-16
ES2060415T3 (es) 1994-11-16
IL100054A (en) 1996-05-14
JP2977613B2 (ja) 1999-11-15
EP0557345A1 (en) 1993-09-01
DE69104059D1 (de) 1994-10-20

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Effective date: 19941129