IT1247165B - Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie. - Google Patents
Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie.Info
- Publication number
- IT1247165B IT1247165B ITPD910055A ITPD910055A IT1247165B IT 1247165 B IT1247165 B IT 1247165B IT PD910055 A ITPD910055 A IT PD910055A IT PD910055 A ITPD910055 A IT PD910055A IT 1247165 B IT1247165 B IT 1247165B
- Authority
- IT
- Italy
- Prior art keywords
- phosphatidylserine
- therapeutic use
- immunitary
- dysfunctions
- derivatives
- Prior art date
Links
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 title abstract 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000003412 degenerative effect Effects 0.000 title 1
- 230000004064 dysfunction Effects 0.000 title 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000001991 pathophysiological effect Effects 0.000 abstract 1
- 238000011422 pharmacological therapy Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invenzione si riferisce ad un nuovo uso terapeutico della fosfatidilserina e di vari composti chimici ad essa affini in diverse patologie degenerative, anche associate a disfunzioni immunitarie, in cui è coinvolto il cosiddetto "tumor necrosis factor" (TNF).L'innovatività dell'applicazione in oggetto è di particolare rilevanza per la terapia farmacologica di patologie quali la sclerosi multipla (SM) e di diverse altre manifestazioni (fisiopatologiche) in cui è noto l'intervento del sopraddetto fattore.-
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910055A IT1247165B (it) | 1991-03-15 | 1991-03-15 | Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie. |
| EP92104039A EP0505817A1 (en) | 1991-03-15 | 1992-03-10 | Use of phosphatidylserine and its derivatives for the manufacture of a medicament for the treatment of degenerative pathologies also associated with immune disfunctions |
| CA002063039A CA2063039A1 (en) | 1991-03-15 | 1992-03-13 | Use of phosphatidylserine and its derivatives in degenerative pathologies also associated with immune disfunctions |
| JP4055015A JPH05124978A (ja) | 1991-03-15 | 1992-03-13 | 免疫不全との関連を有する退行性病変におけるホスフアチジルセリンおよびその誘導体の使用 |
| KR1019920004186A KR920017659A (ko) | 1991-03-15 | 1992-03-14 | 면역 이상작용과 관련된 변성 병변에서 포스파티딜세린 및 이의 유도체의 용도 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD910055A IT1247165B (it) | 1991-03-15 | 1991-03-15 | Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD910055A0 ITPD910055A0 (it) | 1991-03-15 |
| ITPD910055A1 ITPD910055A1 (it) | 1992-09-15 |
| IT1247165B true IT1247165B (it) | 1994-12-12 |
Family
ID=11389504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITPD910055A IT1247165B (it) | 1991-03-15 | 1991-03-15 | Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0505817A1 (it) |
| JP (1) | JPH05124978A (it) |
| KR (1) | KR920017659A (it) |
| CA (1) | CA2063039A1 (it) |
| IT (1) | IT1247165B (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9203039D0 (en) * | 1992-02-13 | 1992-03-25 | Univ London | Treatment |
| AU3333695A (en) * | 1994-05-31 | 1995-12-21 | David P. Franklin | Methods and products for the control of pathogenic bacteria |
| US7262167B2 (en) | 1995-11-06 | 2007-08-28 | Exibona Ltd. | Drug, in particular for modulating the immunological response for the control of viruses, tumors, bacteria and parasites |
| US6165997A (en) * | 1997-11-20 | 2000-12-26 | Statens Serum Institut | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
| GB9919131D0 (en) * | 1999-08-14 | 1999-10-13 | Depuy Int Ltd | Joint lubrication |
| EP1292288B1 (en) * | 2000-06-23 | 2004-09-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury |
| TWI281407B (en) | 2000-09-18 | 2007-05-21 | Vasogen Ireland Ltd | Apoptosis-mimicking synthetic entities and use thereof in medical treatment |
| CA2319928A1 (en) * | 2000-09-18 | 2002-03-18 | Vasogen Ireland Limited | Apoptosis-mimicking synthetic entities and use thereof in medical treatments |
| EP1425020A4 (en) * | 2001-08-20 | 2005-05-18 | Tatton Technologies Llc | METHOD AND COMPOSITIONS FOR TREATING APOPTOSIS-RELATED DISEASES |
| KR20060066624A (ko) * | 2004-10-20 | 2006-06-16 | 주식회사 두산 | 포스파티딜세린을 함유하는 피부 보호 및 개선용 또는 피부장벽 기능 강화용 조성물 |
| GB0425932D0 (en) * | 2004-11-25 | 2004-12-29 | Btg Int Ltd | Structured phospholipids |
| JP5140824B2 (ja) * | 2006-04-19 | 2013-02-13 | 国立大学法人 東京大学 | リゾホスファチジルスレオニンおよびその誘導体 |
| IL182372A0 (en) * | 2007-04-01 | 2008-01-20 | Enzymotec Ltd | Compositions containing phosphatidylserine in treating diabetes-associated conditions |
| JP2010184867A (ja) * | 2009-02-10 | 2010-08-26 | Univ Of Tokyo | リゾホスファチジルスレオニン誘導体 |
| JP2014157014A (ja) * | 2011-05-19 | 2014-08-28 | Tohoku Univ | 自己免疫疾患治療薬のスクリーニング方法 |
| US20160317560A1 (en) * | 2013-11-07 | 2016-11-03 | The University Of North Carolina At Chapel Hill | Particles containing phospholipids or bioactive fatty acids and uses thereof |
| CN110985903B (zh) | 2019-12-31 | 2020-08-14 | 江苏舒适照明有限公司 | 一种灯模组 |
| JP2023149482A (ja) * | 2022-03-31 | 2023-10-13 | 雪印メグミルク株式会社 | 中枢神経炎症抑制組成物及び組成物を含む飲食品、医薬品、飼料 |
| WO2025009518A1 (ja) * | 2023-07-04 | 2025-01-09 | 国立大学法人大阪大学 | 悪液質の予防または改善剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1212900B (it) * | 1983-11-17 | 1989-11-30 | Valle Francesco Della | Uso terapeutico della fosfatidilserina in malattie del sistema nervoso centrale senza effetti sulla coagulazione sanguigna |
| US5403592A (en) * | 1987-08-25 | 1995-04-04 | Macnaught Pty Limited | Lubricant composition for rheumatism |
-
1991
- 1991-03-15 IT ITPD910055A patent/IT1247165B/it active IP Right Grant
-
1992
- 1992-03-10 EP EP92104039A patent/EP0505817A1/en not_active Withdrawn
- 1992-03-13 JP JP4055015A patent/JPH05124978A/ja active Pending
- 1992-03-13 CA CA002063039A patent/CA2063039A1/en not_active Abandoned
- 1992-03-14 KR KR1019920004186A patent/KR920017659A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0505817A1 (en) | 1992-09-30 |
| ITPD910055A0 (it) | 1991-03-15 |
| JPH05124978A (ja) | 1993-05-21 |
| KR920017659A (ko) | 1992-10-21 |
| CA2063039A1 (en) | 1992-09-16 |
| ITPD910055A1 (it) | 1992-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940315 |