IT1247698B - 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti - Google Patents

1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Info

Publication number
IT1247698B
IT1247698B IT04808790A IT4808790A IT1247698B IT 1247698 B IT1247698 B IT 1247698B IT 04808790 A IT04808790 A IT 04808790A IT 4808790 A IT4808790 A IT 4808790A IT 1247698 B IT1247698 B IT 1247698B
Authority
IT
Italy
Prior art keywords
memory
pharmaceutical compositions
caprolattami
alchil
acylamine
Prior art date
Application number
IT04808790A
Other languages
English (en)
Other versions
IT9048087A0 (it
IT9048087A1 (it
Inventor
Fabio Giannessi
Orlando Ghirardi
Domenico Misiti
Maria Ornella Tinti
Roberto Cozzolino
Carlo Scolastico
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT9048087A0 publication Critical patent/IT9048087A0/it
Priority to IT04808790A priority Critical patent/IT1247698B/it
Priority to EP91830276A priority patent/EP0462949B1/en
Priority to ES91830276T priority patent/ES2081463T3/es
Priority to AT91830276T priority patent/ATE131159T1/de
Priority to DK91830276.1T priority patent/DK0462949T3/da
Priority to DE69115135T priority patent/DE69115135T2/de
Priority to US07/718,645 priority patent/US5155102A/en
Priority to JP3150301A priority patent/JPH04230266A/ja
Publication of IT9048087A1 publication Critical patent/IT9048087A1/it
Application granted granted Critical
Publication of IT1247698B publication Critical patent/IT1247698B/it
Priority to GR960400482T priority patent/GR3019076T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IT04808790A 1990-06-21 1990-06-21 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti IT1247698B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT04808790A IT1247698B (it) 1990-06-21 1990-06-21 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
DK91830276.1T DK0462949T3 (da) 1990-06-21 1991-06-20 3-(Acylamino- og 1-alkyl-3-(acylamino)-epsilon-caprolactamer til forøgelse af indlæring og hukommelse og farmaceutiske præparater indeholdende disse
ES91830276T ES2081463T3 (es) 1990-06-21 1991-06-20 1-alquil-3-(acilamino)-epsilon-caprolactamas como mejoradores del aprendimiento y memoria y composiciones farmaceuticas que las contienen.
AT91830276T ATE131159T1 (de) 1990-06-21 1991-06-20 1-alkyl-3-(acylamino)-epsilon-caprolactame zur verbesserung der lernfähigkeit und des gedächtnisses und diese enthaltende pharmazeutische zubereitungen.
EP91830276A EP0462949B1 (en) 1990-06-21 1991-06-20 1-alkyl-3-(acylamino)-epsilon-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same
DE69115135T DE69115135T2 (de) 1990-06-21 1991-06-20 1-Alkyl-3-(Acylamino)-Epsilon-Caprolactame zur Verbesserung der Lernfähigkeit und des Gedächtnisses und diese enthaltende pharmazeutische Zubereitungen.
US07/718,645 US5155102A (en) 1990-06-21 1991-06-21 1-alkyl-3-(acylamino)-ε-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same
JP3150301A JPH04230266A (ja) 1990-06-21 1991-06-21 学習および記憶力増進剤としての１−アルキル−３−（アシルアミノ）−ε−カプロラクタム類およびそれらを含む医薬組成物
GR960400482T GR3019076T3 (en) 1990-06-21 1996-02-22 1-alkyl-3-(acylamino)-epsilon-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04808790A IT1247698B (it) 1990-06-21 1990-06-21 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Publications (3)

Publication Number Publication Date
IT9048087A0 IT9048087A0 (it) 1990-06-21
IT9048087A1 IT9048087A1 (it) 1991-12-21
IT1247698B true IT1247698B (it) 1994-12-30

Family

ID=11264450

Family Applications (1)

Application Number Title Priority Date Filing Date
IT04808790A IT1247698B (it) 1990-06-21 1990-06-21 1-alchil-3-(acilammino)-e-caprolattami quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Country Status (9)

Country Link
US (1) US5155102A (it)
EP (1) EP0462949B1 (it)
JP (1) JPH04230266A (it)
AT (1) ATE131159T1 (it)
DE (1) DE69115135T2 (it)
DK (1) DK0462949T3 (it)
ES (1) ES2081463T3 (it)
GR (1) GR3019076T3 (it)
IT (1) IT1247698B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU756174B2 (en) * 1999-02-09 2003-01-09 Bristol-Myers Squibb Company Lactam inhibitors of FXa and method
US6344450B1 (en) 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
CA2360305A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company Lactam inhibitors of fxa and method
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
DK1691814T3 (da) * 2003-12-01 2012-10-29 Cambridge Entpr Ltd Antiinflammatoriske midler
WO2005082849A1 (en) * 2004-02-23 2005-09-09 Trustees Of Tufts College Lactams as conformationally constrained peptidomimetic inhibitors
GB2418425B (en) * 2004-08-11 2008-09-03 Univ Cambridge Tech Anti-inflammatory agents
GB201009603D0 (en) 2010-06-08 2010-07-21 Cambridge Entpr Ltd Anti-inflammatory agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1231921B (it) * 1989-06-12 1992-01-15 Sigma Tau Ind Farmaceuti 1-acil-2-pirrolidoni quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti

Also Published As

Publication number Publication date
ATE131159T1 (de) 1995-12-15
DE69115135D1 (de) 1996-01-18
EP0462949B1 (en) 1995-12-06
IT9048087A0 (it) 1990-06-21
US5155102A (en) 1992-10-13
GR3019076T3 (en) 1996-05-31
DE69115135T2 (de) 1996-05-09
IT9048087A1 (it) 1991-12-21
JPH04230266A (ja) 1992-08-19
ES2081463T3 (es) 1996-03-16
DK0462949T3 (da) 1996-02-05
EP0462949A1 (en) 1991-12-27

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940526