IT1249708B - Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. - Google Patents

Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.

Info

Publication number
IT1249708B
IT1249708B ITRM910710A ITRM910710A IT1249708B IT 1249708 B IT1249708 B IT 1249708B IT RM910710 A ITRM910710 A IT RM910710A IT RM910710 A ITRM910710 A IT RM910710A IT 1249708 B IT1249708 B IT 1249708B
Authority
IT
Italy
Prior art keywords
tnf
biologically active
determining
necrosis factor
active form
Prior art date
Application number
ITRM910710A
Other languages
English (en)
Inventor
Angelo Corti
Original Assignee
Tecnogen Scpa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecnogen Scpa filed Critical Tecnogen Scpa
Priority to ITRM910710A priority Critical patent/IT1249708B/it
Publication of ITRM910710A0 publication Critical patent/ITRM910710A0/it
Priority to JP5505949A priority patent/JPH07502113A/ja
Priority to PCT/IT1992/000116 priority patent/WO1993006489A1/en
Priority to EP92921308A priority patent/EP0605635A1/en
Priority to AU26905/92A priority patent/AU2690592A/en
Publication of ITRM910710A1 publication Critical patent/ITRM910710A1/it
Application granted granted Critical
Publication of IT1249708B publication Critical patent/IT1249708B/it

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

E' descritto un metodo per la rivelazione del TNF biologicamente attivo oligomerico, che utilizza reagenti capaci di reagire solo con TNF in forma oligomerica ma non con TNF complessato al recettore, ne con TNF in forma monomerica. E' anche descritto un kit per la realizzazione.
ITRM910710A 1991-09-23 1991-09-23 Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. IT1249708B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITRM910710A IT1249708B (it) 1991-09-23 1991-09-23 Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
JP5505949A JPH07502113A (ja) 1991-09-23 1992-09-17 生理活性型の腫瘍壊死因子（ｔｎｆ）の検出方法
PCT/IT1992/000116 WO1993006489A1 (en) 1991-09-23 1992-09-17 Method to detect tumor necrosis factor (tnf) as bioactive form
EP92921308A EP0605635A1 (en) 1991-09-23 1992-09-17 Method to detect tumor necrosis factor (tnf) as bioactive form
AU26905/92A AU2690592A (en) 1991-09-23 1992-09-17 Method to detect tumor necrosis factor (tnf) as bioactive form

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM910710A IT1249708B (it) 1991-09-23 1991-09-23 Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.

Publications (3)

Publication Number Publication Date
ITRM910710A0 ITRM910710A0 (it) 1991-09-23
ITRM910710A1 ITRM910710A1 (it) 1993-03-23
IT1249708B true IT1249708B (it) 1995-03-09

Family

ID=11400369

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM910710A IT1249708B (it) 1991-09-23 1991-09-23 Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.

Country Status (5)

Country Link
EP (1) EP0605635A1 (it)
JP (1) JPH07502113A (it)
AU (1) AU2690592A (it)
IT (1) IT1249708B (it)
WO (1) WO1993006489A1 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649352B1 (en) * 1999-01-29 2003-11-18 Center For Molecular Medicine And Immunology Method of evaluating myelosuppressive state
US7112409B2 (en) 1999-01-29 2006-09-26 Center For Molecular Medicine And Immunology Method of determining cytokine dosage for myelosuppressive state
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

Also Published As

Publication number Publication date
JPH07502113A (ja) 1995-03-02
ITRM910710A1 (it) 1993-03-23
AU2690592A (en) 1993-04-27
EP0605635A1 (en) 1994-07-13
WO1993006489A1 (en) 1993-04-01
ITRM910710A0 (it) 1991-09-23

Similar Documents

Publication Publication Date Title
EP0935140A3 (en) Novel methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
DE69637855D1 (de) Verbindungen mit wachstumshormon-freisetzenden eigenschaften
TR28913A (tr) Gelistirilmis 16x9' luk görünüm oranli yüz plakasina sahip olan katod isini tüpü.
ATE95311T1 (de) Potential-verursachende membran fuer immunosensoren.
IT1264712B1 (it) Metodo di sintesi biologica di peptidi
IL129535A (en) Method of diagnosing bone dysbolism
EP0652435A3 (de) Sensor zur Bestimmung des Verlaufs der Konzentration.
ATE335763T1 (de) Sandwich-immunoassay zur bestimmung von proanp- teilpeptiden
CA2177179A1 (en) Antagonists to chaperonin 10
ES2062588T3 (es) Procedimiento de obtencion de kappa-caseino-macropeptidos.
IT8720605A0 (it) Dispositivo per la determinazione delle inclinazione di un piano rispetto ad un piano orizzontale teorico.
DK0760010T3 (da) Fremgangsmåder til screening for Crohn's sygdom under anvendelse af TNF-mikrosatellit-alleler
IT1249708B (it) Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
FR2668209B1 (fr) Pompe d'aspiration moleculaire.
FR2706484B1 (fr) Polypeptide mutant de la protéine kinase C, séquences d'acides nucléiques codant pour ledit polypeptide et leurs utilisations.
DE69005370D1 (de) Membranmessfühler mit Konzentration von Deformationen.
RU95108545A (ru) Способ и комплект для выявления и оценки риска развития периодонтита
AU6873587A (en) Monoclonal antibodies useful in the identification of microorganisms causing peridontal disease
DE69102671D1 (de) Taumelscheibenverdichter.
EP0185433A3 (en) Retro-inverted peptides analogues of bradykinin potentiator bpp 5a
Golba Jr et al. Complex Blends Need Both Compatibility and SEC
Slater Partners in finance
ATE231167T1 (de) Pd-ecgf / thymidin phosphorylase spezifischer monoklonaler antikörper
ES2133502T3 (es) Composicion de limpieza estabilizada a base de 1,1-dicloro-1-fluoretano y de metanol.
Mozart et al. The marriage of Figaro: overture

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960909