IT1252163B - Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica - Google Patents
Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemicaInfo
- Publication number
- IT1252163B IT1252163B ITMI913241A ITMI913241A IT1252163B IT 1252163 B IT1252163 B IT 1252163B IT MI913241 A ITMI913241 A IT MI913241A IT MI913241 A ITMI913241 A IT MI913241A IT 1252163 B IT1252163 B IT 1252163B
- Authority
- IT
- Italy
- Prior art keywords
- neuroprotection
- degenerative
- ischemic
- neurological diseases
- pharmaceutical compositions
- Prior art date
Links
- 230000003412 degenerative effect Effects 0.000 title abstract 2
- 230000004112 neuroprotection Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- QHZUABXEBRGBLP-LKWYKXIFSA-N (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-4-benzyl-9b-hydroxy-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,9R,10aR)-N-[(2R,4R,9aS,9bR)-9b-hydroxy-3,5-dioxo-2,4-di(propan-2-yl)-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide (6aR,10aR)-N-[(2S,4S,9bS)-9b-hydroxy-4-(2-methylpropyl)-3,5-dioxo-2-propan-2-yl-3a,4,7,8,9,9a-hexahydrofuro[3,2-g]indolizin-2-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)C4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2CC(CN(C)[C@@H]2C2)C(=O)N[C@@]3(C(=O)C4[C@@H](C(N5CCCC5[C@@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(C21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 QHZUABXEBRGBLP-LKWYKXIFSA-N 0.000 abstract 1
- ZAGRKAFMISFKIO-UHFFFAOYSA-N Isolysergic acid Natural products C1=CC(C2=CC(CN(C2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 abstract 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 abstract 1
- 229960002802 bromocriptine Drugs 0.000 abstract 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 abstract 1
- 229960004318 dihydroergocristine Drugs 0.000 abstract 1
- LIMAOLZSWRJOMG-HJPBWRTMSA-N dihydroergocristine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C(C)C)C1=CC=CC=C1 LIMAOLZSWRJOMG-HJPBWRTMSA-N 0.000 abstract 1
- 229960002032 dihydroergocryptine Drugs 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- JKAHWGPTNVUTNB-IXPVHAAZSA-N lergotrile Chemical compound C1=CC([C@H]2C[C@@H](CC#N)CN([C@@H]2C2)C)=C3C2=C(Cl)NC3=C1 JKAHWGPTNVUTNB-IXPVHAAZSA-N 0.000 abstract 1
- 229950007886 lergotrile Drugs 0.000 abstract 1
- 229960003587 lisuride Drugs 0.000 abstract 1
- ZAGRKAFMISFKIO-QMTHXVAHSA-N lysergic acid Chemical compound C1=CC(C2=C[C@H](CN([C@@H]2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-QMTHXVAHSA-N 0.000 abstract 1
- 229960003642 nicergoline Drugs 0.000 abstract 1
- 229960004851 pergolide Drugs 0.000 abstract 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 229960004558 terguride Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invenzione riguarda un nuovo uso terapeutico di derivati delle clavine (nicergolina, lergotrile, pergolide), di amidi dell'acido lisergico (bromocriptina, diidroergocristina, diidroergotossina, ?-diidroergocriptina) e di 8 ?-aminoergoline (lisuride, terguride) per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913241A IT1252163B (it) | 1991-12-03 | 1991-12-03 | Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica |
| DE4240798A DE4240798A1 (en) | 1991-12-03 | 1992-12-01 | Neuro-protective agents preventing nerve damage - contain ergot derivs. e.g. clavine lysergic acid amide or 8-alpha-amino:ergoline derivs. |
| ES09202439A ES2109114B1 (es) | 1991-12-03 | 1992-12-01 | Composiciones farmaceuticas para la neuroproteccion en las enfermedades neurologicas de caracter degenerativo o sobre base isquemica. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI913241A IT1252163B (it) | 1991-12-03 | 1991-12-03 | Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI913241A0 ITMI913241A0 (it) | 1991-12-03 |
| ITMI913241A1 ITMI913241A1 (it) | 1993-06-03 |
| IT1252163B true IT1252163B (it) | 1995-06-05 |
Family
ID=11361248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI913241A IT1252163B (it) | 1991-12-03 | 1991-12-03 | Composizioni farmaceutiche per la neuroprotezione nelle malattie neurologiche di carattere degenerativo o su base ischemica |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE4240798A1 (it) |
| ES (1) | ES2109114B1 (it) |
| IT (1) | IT1252163B (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572879B1 (en) * | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| DE19626621A1 (de) * | 1996-07-02 | 1998-01-08 | Hexal Ag | Pflaster zur transdermalen Anwendung von Pergolid |
| US6623752B1 (en) | 1996-07-02 | 2003-09-23 | Hexal Ag | Patch for transdermal application for pergolid |
| FR2786099B1 (fr) | 1998-11-24 | 2000-12-29 | Aventis Laboratoire | Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline |
| FR2786101B1 (fr) | 1998-11-24 | 2002-07-05 | Aventis Laboratoire | Utilisation de la nicergoline dans le traitement de la spasticite |
| FR2786100B1 (fr) * | 1998-11-24 | 2002-03-01 | Aventis Laboratoire | Nouvelle application therapeutique de la nicergoline |
| FR2801793B1 (fr) * | 1999-12-01 | 2003-07-04 | Aventis Pharma Sa | Association d'une ergoline et de riluzole et son utilisation comme medicament |
| US6297254B1 (en) | 1999-12-01 | 2001-10-02 | Aventis Pharma S. A. | Method for the prevention or treatment of a motoneuron disease |
| DE10053397A1 (de) | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10226459A1 (de) * | 2002-06-13 | 2004-01-08 | Neurobiotec Gmbh | Verwendung von Dopamin-Partialagonisten zur Behandlung des Restless Legs Syndroms |
| DK2091537T3 (da) * | 2006-11-23 | 2013-08-26 | Sinoxa Pharma Gmbh | Farmaceutiske sammensætninger til behandlingen af kapillær arteriopati |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1200603B (it) * | 1985-04-04 | 1989-01-27 | Poli Ind Chimica Spa | Composizione farmaceutiche ad attivita dopaminergica |
-
1991
- 1991-12-03 IT ITMI913241A patent/IT1252163B/it active IP Right Grant
-
1992
- 1992-12-01 ES ES09202439A patent/ES2109114B1/es not_active Expired - Lifetime
- 1992-12-01 DE DE4240798A patent/DE4240798A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2109114A1 (es) | 1998-01-01 |
| DE4240798A1 (en) | 1993-06-09 |
| ITMI913241A0 (it) | 1991-12-03 |
| ES2109114B1 (es) | 1998-06-16 |
| ITMI913241A1 (it) | 1993-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971223 |