IT1254687B - Gene inducibile da citochine - Google Patents

Gene inducibile da citochine

Info

Publication number
IT1254687B
IT1254687B ITMI920901A ITMI920901A IT1254687B IT 1254687 B IT1254687 B IT 1254687B IT MI920901 A ITMI920901 A IT MI920901A IT MI920901 A ITMI920901 A IT MI920901A IT 1254687 B IT1254687 B IT 1254687B
Authority
IT
Italy
Prior art keywords
cytokines
gene
inducible
gene inducible
pentaxine
Prior art date
Application number
ITMI920901A
Other languages
English (en)
Inventor
Daniela Modena
Giuseppe Legname
Alberto Mantovani
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to ITMI920901A priority Critical patent/IT1254687B/it
Publication of ITMI920901A0 publication Critical patent/ITMI920901A0/it
Priority to CA002087787A priority patent/CA2087787A1/en
Priority to PCT/EP1993/000868 priority patent/WO1993021313A1/en
Publication of ITMI920901A1 publication Critical patent/ITMI920901A1/it
Application granted granted Critical
Publication of IT1254687B publication Critical patent/IT1254687B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invenzione si riferisce a un gene precedentemente non noto, appartenente alla famiglia delle pentaxine, che è inducibile da una o più citochine, e la cui espressione non è limitata ad epatociti, l'mRNA essendo abbondante in cellule fibroblastiche ed endoteliali attivate da citochine, e il gene essendo fortemente indotto da TNfa e IL-1, ma non da IL-6 (l'induttore principale di SAP e CRP), cosicché l'analisi del prodotto d'espressione può fornire un'indicazione indipendente di stress tissutale nella maggior parte di tipi di tessuto.
ITMI920901A 1992-04-14 1992-04-14 Gene inducibile da citochine IT1254687B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI920901A IT1254687B (it) 1992-04-14 1992-04-14 Gene inducibile da citochine
CA002087787A CA2087787A1 (en) 1992-04-14 1993-01-21 Cloning and characterization of a gene, inducible by cytokines
PCT/EP1993/000868 WO1993021313A1 (en) 1992-04-14 1993-04-08 Cloning and characterization of a gene, inducible by cytokines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920901A IT1254687B (it) 1992-04-14 1992-04-14 Gene inducibile da citochine

Publications (3)

Publication Number Publication Date
ITMI920901A0 ITMI920901A0 (it) 1992-04-14
ITMI920901A1 ITMI920901A1 (it) 1993-10-14
IT1254687B true IT1254687B (it) 1995-09-28

Family

ID=11362923

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920901A IT1254687B (it) 1992-04-14 1992-04-14 Gene inducibile da citochine

Country Status (3)

Country Link
CA (1) CA2087787A1 (it)
IT (1) IT1254687B (it)
WO (1) WO1993021313A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1298487B1 (it) 1997-12-19 2000-01-10 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
EP1361433A3 (en) * 2002-04-09 2005-02-23 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Method for estimating therapeutic efficacy of tumor necrosis factor (TNF)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571442A4 (en) * 1991-01-14 1995-05-03 Univ New York PROTEIN TSG-14 INDUCED BY CYTOKINE, DNA ENCODING THE PROTEIN AND USES THEREOF.

Also Published As

Publication number Publication date
WO1993021313A1 (en) 1993-10-28
CA2087787A1 (en) 1993-10-15
ITMI920901A1 (it) 1993-10-14
ITMI920901A0 (it) 1992-04-14

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