IT1255462B - Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrine - Google Patents
Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrineInfo
- Publication number
- IT1255462B IT1255462B ITMI921833A ITMI921833A IT1255462B IT 1255462 B IT1255462 B IT 1255462B IT MI921833 A ITMI921833 A IT MI921833A IT MI921833 A ITMI921833 A IT MI921833A IT 1255462 B IT1255462 B IT 1255462B
- Authority
- IT
- Italy
- Prior art keywords
- nimesulide
- preparation
- cyclodestrine
- inclusion compounds
- milling
- Prior art date
Links
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000965 nimesulide Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 238000003801 milling Methods 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000008240 homogeneous mixture Substances 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Si descrive un metodo per la preparazione di composti di inclusione di nimesulide con ciclodestrine che consiste nel sottoporre una miscela solida, una soluzione acquosa o un impasto omogeneo di nimesulide e ciclodestrina idrosolubile rispettivamente a co-mulinazione, essiccamento spray o mulinazione ed essiccazione.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921833A IT1255462B (it) | 1992-07-28 | 1992-07-28 | Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrine |
| PCT/EP1993/001560 WO1994002177A1 (en) | 1992-07-28 | 1993-06-18 | Method of preparation of inclusion compounds of nimesulide with cyclodextrins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI921833A IT1255462B (it) | 1992-07-28 | 1992-07-28 | Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI921833A0 ITMI921833A0 (it) | 1992-07-28 |
| ITMI921833A1 ITMI921833A1 (it) | 1994-01-28 |
| IT1255462B true IT1255462B (it) | 1995-11-02 |
Family
ID=11363762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI921833A IT1255462B (it) | 1992-07-28 | 1992-07-28 | Metodo di preparazione di composti di inclusione di nimesulide con ciclodestrine |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | IT1255462B (it) |
| WO (1) | WO1994002177A1 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA57734C2 (uk) | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Комплекси включення арилгетероциклічних солей |
| IT1298732B1 (it) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1227626B (it) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione |
| IT1248475B (it) * | 1990-05-22 | 1995-01-19 | Angeli Inst Spa | Composti di inclusione di nimesulide con ciclodestrine |
| ES2023552A6 (es) * | 1990-05-22 | 1992-01-16 | Leetrim Limited | Procedimiento para la preparacion de compuestos de inclusion de nimesulida con ciclodextrina. |
-
1992
- 1992-07-28 IT ITMI921833A patent/IT1255462B/it active IP Right Grant
-
1993
- 1993-06-18 WO PCT/EP1993/001560 patent/WO1994002177A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI921833A1 (it) | 1994-01-28 |
| ITMI921833A0 (it) | 1992-07-28 |
| WO1994002177A1 (en) | 1994-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |