IT1257793B - Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato - Google Patents

Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato

Info

Publication number
IT1257793B
IT1257793B ITBO920183A ITBO920183A IT1257793B IT 1257793 B IT1257793 B IT 1257793B IT BO920183 A ITBO920183 A IT BO920183A IT BO920183 A ITBO920183 A IT BO920183A IT 1257793 B IT1257793 B IT 1257793B
Authority
IT
Italy
Prior art keywords
microgranules
pharmaceutical composition
controlled release
composition based
biliary acids
Prior art date
Application number
ITBO920183A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ITBO920183A priority Critical patent/IT1257793B/it
Publication of ITBO920183A0 publication Critical patent/ITBO920183A0/it
Priority to EP93830203A priority patent/EP0571338A1/en
Priority to CA002096394A priority patent/CA2096394A1/en
Priority to US08/063,442 priority patent/US5422124A/en
Priority to JP5116215A priority patent/JPH0632739A/ja
Publication of ITBO920183A1 publication Critical patent/ITBO920183A1/it
Application granted granted Critical
Publication of IT1257793B publication Critical patent/IT1257793B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Una composizione farmaceutica per uso orale a rilascio controllato del principio attivo comprendente una molteplicità di microgranuli ognuno dei quali è costituito da un nucleo di acido biliare e legante e da una membrana, applicata su detto nucleo di principio attivo, in grado di cedere detto acido biliare in tempi successivi a scadenza sostanzialmente regolare.
ITBO920183A 1992-05-18 1992-05-18 Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato IT1257793B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITBO920183A IT1257793B (it) 1992-05-18 1992-05-18 Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato
EP93830203A EP0571338A1 (en) 1992-05-18 1993-05-14 Pharmaceutical oral controlled release composition comprising small pellets of bile acids
CA002096394A CA2096394A1 (en) 1992-05-18 1993-05-17 Pharmaceutical oral controlled release composition comprising small pellets of bile acids
US08/063,442 US5422124A (en) 1992-05-18 1993-05-18 Pharmaceutical oral controlled release composition comprising small pellets of bile acids
JP5116215A JPH0632739A (ja) 1992-05-18 1993-05-18 胆汁酸の小ペレットを含有する徐放性経口薬剤組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITBO920183A IT1257793B (it) 1992-05-18 1992-05-18 Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato

Publications (3)

Publication Number Publication Date
ITBO920183A0 ITBO920183A0 (it) 1992-05-18
ITBO920183A1 ITBO920183A1 (it) 1993-11-18
IT1257793B true IT1257793B (it) 1996-02-13

Family

ID=11338261

Family Applications (1)

Application Number Title Priority Date Filing Date
ITBO920183A IT1257793B (it) 1992-05-18 1992-05-18 Composizione farmaceutica a base di acidi biliari in microgranuli a rilascio controllato

Country Status (5)

Country Link
US (1) US5422124A (it)
EP (1) EP0571338A1 (it)
JP (1) JPH0632739A (it)
CA (1) CA2096394A1 (it)
IT (1) IT1257793B (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
ITMI20012572A1 (it) * 2001-12-06 2003-06-06 Istituto Biochimico Italiano Microgranuli di acido ursodesossicolico
US20100183730A1 (en) * 2007-04-19 2010-07-22 Johannes Jan Platteeuw High dose composition of ursodeoxycholic acid
EP2265347B1 (en) 2008-03-06 2014-10-08 Leverage Design Ltd. Transportation device with pivoting axle
US20110268794A1 (en) * 2009-01-09 2011-11-03 Camilleri Michael L Methods and materials for delivering bile acids
PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
JP6097695B2 (ja) * 2010-11-08 2017-03-15 アルビレオ アクチエボラグ Ｉｂａｔ阻害剤および胆汁酸結合剤を含む薬学的組み合わせ
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
CA2952406A1 (en) 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for preventing or reducing coloration thereof
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
JP2020530448A (ja) 2017-08-09 2020-10-22 アルビレオ・アクチボラグ コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
ES2942443T3 (es) 2018-06-05 2023-06-01 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
BR112020024479A2 (pt) 2018-06-20 2021-03-02 Albireo Ab hidrato cristalino, modificações cristalinas de odevixibat, solvato misto de odevixibat, uso de modificação cristalina de odevixibat, processo para a preparação de modificação cristalina de odevixibat, e, composição farmacêutica
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859437A (en) * 1972-06-02 1975-01-07 Intellectual Property Dev Corp Reducing cholesterol levels
FR2152379A1 (en) * 1971-09-09 1973-04-27 Henry Michel Bile acid/dried pancreas compositions - for treating obesity
IT1076001B (it) * 1977-01-04 1985-04-22 Also Lab Di Dr P Sorbini & C S Composizione per il trattamento del cuoio capelluto e contro la caduta dei capelli
IT1101649B (it) * 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
IT1142639B (it) * 1981-12-29 1986-10-08 Proter Spa Composizioni terapeutiche ad attivita' coleretica contenenti come principio attivo derivati dall'acido colanico
IT1213390B (it) * 1986-11-28 1989-12-20 Gipharmex Spa Composizioni farmaceutiche ad uso orale del tipo a cessione controllata nel tempo contenenti composti a struttura steroidea attivi nelle alterazioni del metabolismo del colesterolo.
IT1212141B (it) * 1987-06-03 1989-11-08 So Ri Far S R L Composizioni farmaceutiche per la prevenzione e terapia della calcolosi delle vie biliari e della dispepsia biliare.
US5091192A (en) * 1990-01-16 1992-02-25 Natur-All Systems, Inc. Bile salts permanently bound to insoluble cellulose as a dietary supplement

Also Published As

Publication number Publication date
ITBO920183A0 (it) 1992-05-18
JPH0632739A (ja) 1994-02-08
EP0571338A1 (en) 1993-11-24
US5422124A (en) 1995-06-06
CA2096394A1 (en) 1993-11-19
ITBO920183A1 (it) 1993-11-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970529