IT1261404B - Purificazione di acidi colanici - Google Patents
Purificazione di acidi colaniciInfo
- Publication number
- IT1261404B IT1261404B ITTO931002A ITTO931002A IT1261404B IT 1261404 B IT1261404 B IT 1261404B IT TO931002 A ITTO931002 A IT TO931002A IT TO931002 A ITTO931002 A IT TO931002A IT 1261404 B IT1261404 B IT 1261404B
- Authority
- IT
- Italy
- Prior art keywords
- purification
- colanic
- acids
- crude mixture
- salification
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960001091 chenodeoxycholic acid Drugs 0.000 abstract 1
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 1
- 229960001661 ursodiol Drugs 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
Abstract
La presente invenzione concerne un procedimento di purificazione dell'acido ursodesossicolico a partire da una miscela grezza contenente delle quantità variabili di acido chenodesossicolico e altre impurezze che comprende la salificazione della miscela grezza con trietilammina in un solvente opportuno, l'isolamento, l'eventuale cristallizzazione e la neutralizzazione dell'insolubile di reazione.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9215862 | 1992-12-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITTO931002A0 ITTO931002A0 (it) | 1993-12-28 |
| ITTO931002A1 ITTO931002A1 (it) | 1995-06-28 |
| IT1261404B true IT1261404B (it) | 1996-05-20 |
Family
ID=9437231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITTO931002A IT1261404B (it) | 1992-12-29 | 1993-12-28 | Purificazione di acidi colanici |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1261404B (it) |
-
1993
- 1993-12-28 IT ITTO931002A patent/IT1261404B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITTO931002A0 (it) | 1993-12-28 |
| ITTO931002A1 (it) | 1995-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19981231 |