IT1265964B1 - Micro-granuli ottenuti tramite estrusione-sferonizzazione contenenti una ciclodestrina. - Google Patents

Micro-granuli ottenuti tramite estrusione-sferonizzazione contenenti una ciclodestrina.

Info

Publication number
IT1265964B1
IT1265964B1 IT94TO000406A ITTO940406A IT1265964B1 IT 1265964 B1 IT1265964 B1 IT 1265964B1 IT 94TO000406 A IT94TO000406 A IT 94TO000406A IT TO940406 A ITTO940406 A IT TO940406A IT 1265964 B1 IT1265964 B1 IT 1265964B1
Authority
IT
Italy
Prior art keywords
micro
spheronization
extrusion
cyclodextrin
granules
Prior art date
Application number
IT94TO000406A
Other languages
English (en)
Inventor
Ferdinando Giordano
Andrea Gazzaniga
Ernesto Fossati
Philippe Lefevre
Original Assignee
Roquette Freres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roquette Freres filed Critical Roquette Freres
Publication of ITTO940406A0 publication Critical patent/ITTO940406A0/it
Publication of ITTO940406A1 publication Critical patent/ITTO940406A1/it
Application granted granted Critical
Publication of IT1265964B1 publication Critical patent/IT1265964B1/it

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/30—Layered or coated, e.g. dust-preventing coatings
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/45—Form not covered by groups C05G5/10 - C05G5/18, C05G5/20 - C05G5/27, C05G5/30 - C05G5/38 or C05G5/40, e.g. soluble or permeable packaging

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invenzione ha per oggetto dei micro - granuli ottenuti tramite estrusione - sferonizzazione comprendente almeno una ciclodestrina in quanto eccipiente. Essa ha ugualmente per oggetto il procedimento di preparazione di questi micro - granuli tramite estrusione - sferonizzazione, così come l'utilizzazione di una ciclodestrina in quanto eccipiente per la fabricazione di micro - granuli tramite estrusione - sferonizzazione, questi micro - granulari permettendo la liberazione controllata dei principi attivi farmaceutici, per la sanità animale o agrochimica.
IT94TO000406A 1993-05-28 1994-05-20 Micro-granuli ottenuti tramite estrusione-sferonizzazione contenenti una ciclodestrina. IT1265964B1 (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9306430A FR2705677B1 (fr) 1993-05-28 1993-05-28 Micro-granules obtenus par extrusion-sphéronisation contenant une cyclodextrine.

Publications (3)

Publication Number Publication Date
ITTO940406A0 ITTO940406A0 (it) 1994-05-20
ITTO940406A1 ITTO940406A1 (it) 1995-11-20
IT1265964B1 true IT1265964B1 (it) 1996-12-16

Family

ID=9447555

Family Applications (1)

Application Number Title Priority Date Filing Date
IT94TO000406A IT1265964B1 (it) 1993-05-28 1994-05-20 Micro-granuli ottenuti tramite estrusione-sferonizzazione contenenti una ciclodestrina.

Country Status (2)

Country Link
FR (1) FR2705677B1 (it)
IT (1) IT1265964B1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721512A1 (fr) * 1994-06-28 1995-12-29 Maurice Jacob Formulation et procédé de préparation de sphéroïdes à base de solutions d'origine végétale.
TW377357B (en) * 1995-11-23 1999-12-21 Janssen Pharmaceutica Nv Process for preparing solid mixtures comprising cyclodextrins and active ingredients by melt-extrusion
HUP9900730A3 (en) * 1995-11-23 2001-04-28 Janssen Pharmaceutica Nv Solid mixtures of cyclodextrins prepared via melt-extrusion
NL1011307C1 (nl) * 1999-02-15 2000-08-17 Dsm Nv Werkwijze voor het vormgeven van (aard)alkalimetaalbenzoaatdeeltjes.
EP1252886A1 (en) * 2001-04-27 2002-10-30 Universiteit Gent Controlled release pharmaceutical pellet compositions
CA2537607A1 (en) 2003-09-03 2005-03-17 Mallinckrodt Inc. Granular sustained release preparation and production thereof
EP1804772B1 (en) * 2004-08-12 2011-10-05 Reckitt Benckiser Healthcare (UK) Limited Granules comprising a non-steroidal anti-inflammatory drug and a sugar alcohol made by melt extrusion
BE1028699B1 (fr) * 2020-10-13 2022-05-16 Eleonor Composition comprenant au moins un diterpène labdanique et son procédé de fabrication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2209669B (en) * 1987-09-11 1992-02-12 Squibb & Sons Inc Pharmaceutical composition containing high drug load and method for preparing same
ES2096624T3 (es) * 1990-04-12 1997-03-16 Shionogi & Co Composicion revestida y su procedimiento de preparacion.
WO1993007859A1 (en) * 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production

Also Published As

Publication number Publication date
FR2705677B1 (fr) 1995-08-11
FR2705677A1 (fr) 1994-12-02
ITTO940406A1 (it) 1995-11-20
ITTO940406A0 (it) 1994-05-20

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970530