IT1271426B - Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1,6-difosfato (fdpna3h*8h20) - Google Patents
Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1,6-difosfato (fdpna3h*8h20)Info
- Publication number
- IT1271426B IT1271426B ITMI930029A ITMI930029A IT1271426B IT 1271426 B IT1271426 B IT 1271426B IT MI930029 A ITMI930029 A IT MI930029A IT MI930029 A ITMI930029 A IT MI930029A IT 1271426 B IT1271426 B IT 1271426B
- Authority
- IT
- Italy
- Prior art keywords
- diphosphate
- trisode
- fdpna3h
- production process
- crystalline fructose
- Prior art date
Links
- 229940025237 fructose 1,6-diphosphate Drugs 0.000 title abstract 2
- RNBGYGVWRKECFJ-ZXXMMSQZSA-N alpha-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ZXXMMSQZSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- RNBGYGVWRKECFJ-ARQDHWQXSA-N beta-D-fructofuranose 1,6-bisphosphate Chemical compound O[C@H]1[C@H](O)[C@@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O RNBGYGVWRKECFJ-ARQDHWQXSA-N 0.000 abstract 2
- XPYBSIWDXQFNMH-UHFFFAOYSA-N D-fructose 1,6-bisphosphate Natural products OP(=O)(O)OCC(O)C(O)C(O)C(=O)COP(O)(O)=O XPYBSIWDXQFNMH-UHFFFAOYSA-N 0.000 abstract 1
- NFWTWCLBRQMPCW-UHFFFAOYSA-N O.O.O.O.O.O.O.O.[Na].[Na].[Na] Chemical compound O.O.O.O.O.O.O.O.[Na].[Na].[Na] NFWTWCLBRQMPCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Si descrive un procedimento per la preparazione del sale trisodico ottaidrato del fruttosio 1,6-difosfato partendo da una soluzione acquosa a pH acido di D-fruttosio 1,6-difosfato, a cui si aggiunge un'opportuna quantità di acetone; si cristallizza e si filtra la miscela reazionale per ottenere il prodotto desiderato, che viene infine essiccato.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI930029A IT1271426B (it) | 1993-01-13 | 1993-01-13 | Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1,6-difosfato (fdpna3h*8h20) |
| DE69406809T DE69406809T2 (de) | 1993-01-13 | 1994-01-07 | Neues Verfahren zur Gewinnung des Oktahydro-Trinatriumsalzes von Fructose-1,6-diphosphat (FdPNa3H*8H2O) in einer kristallinen Form |
| EP94100167A EP0606853B1 (en) | 1993-01-13 | 1994-01-07 | New process for obtaining octahydro trisodium salt of fructose 1,6-diphosphate (FdPNa3H*8H20) in a crystalline form |
| CN94100631A CN1034018C (zh) | 1993-01-13 | 1994-01-13 | 生产晶形果糖-1,6-二磷酸八水三钠盐的新方法 |
| US08/510,871 US5571906A (en) | 1993-01-13 | 1995-08-03 | Process for obtaining octahydro trisodium salt of fructose 1,6-diphosphate (FdPNa3H*8H2O) in crystalline form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI930029A IT1271426B (it) | 1993-01-13 | 1993-01-13 | Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1,6-difosfato (fdpna3h*8h20) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI930029A0 ITMI930029A0 (it) | 1993-01-13 |
| ITMI930029A1 ITMI930029A1 (it) | 1994-07-13 |
| IT1271426B true IT1271426B (it) | 1997-05-28 |
Family
ID=11364622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI930029A IT1271426B (it) | 1993-01-13 | 1993-01-13 | Procedimento di produzione del sale trisodico ottaidrato cristallino del fruttosio 1,6-difosfato (fdpna3h*8h20) |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5571906A (it) |
| EP (1) | EP0606853B1 (it) |
| CN (1) | CN1034018C (it) |
| DE (1) | DE69406809T2 (it) |
| IT (1) | IT1271426B (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3579926B2 (ja) * | 1994-08-25 | 2004-10-20 | ソニー株式会社 | デジタルビデオ信号の再生方法及び再生装置 |
| US5731291A (en) * | 1996-05-08 | 1998-03-24 | Cypros Pharmaceutical Corp. | Partially lyophilized fructose-1,6-diphosphate (FDP) for injection into humans |
| US5944020A (en) * | 1997-02-25 | 1999-08-31 | Cypros Pharmaceutical Corp. | Use of fructose-1 6-diphosphate as an inotrope drug after cardiopulmonary bypass surgery |
| CN1057299C (zh) * | 1998-08-28 | 2000-10-11 | 重庆医科大学 | D-果糖-1,6-二磷酸钠镁、其制备方法和在制备药品上的用途 |
| CN106810583B (zh) * | 2016-12-30 | 2019-04-02 | 珠海同源药业有限公司 | 一种果糖二磷酸钠化合物及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3066135A (en) * | 1959-10-03 | 1962-11-27 | Biomedica Int | Process for the preparation of hexose alkali metal salts of hexose diphosphate from insoluble salts thereof |
-
1993
- 1993-01-13 IT ITMI930029A patent/IT1271426B/it active IP Right Grant
-
1994
- 1994-01-07 DE DE69406809T patent/DE69406809T2/de not_active Expired - Fee Related
- 1994-01-07 EP EP94100167A patent/EP0606853B1/en not_active Expired - Lifetime
- 1994-01-13 CN CN94100631A patent/CN1034018C/zh not_active Expired - Fee Related
-
1995
- 1995-08-03 US US08/510,871 patent/US5571906A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1034018C (zh) | 1997-02-12 |
| EP0606853B1 (en) | 1997-11-19 |
| US5571906A (en) | 1996-11-05 |
| EP0606853A1 (en) | 1994-07-20 |
| ITMI930029A0 (it) | 1993-01-13 |
| DE69406809T2 (de) | 1998-03-19 |
| CN1100726A (zh) | 1995-03-29 |
| DE69406809D1 (de) | 1998-01-02 |
| ITMI930029A1 (it) | 1994-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970124 |